scholarly journals High Sensitivity C-Reactive Protein an inflammatory marker and lipoprotein levels in patients with coronary heart disease

2016 ◽  
Vol 4 (3) ◽  
pp. 444-449
Author(s):  
Dr. Sindu. PC ◽  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Inflammatory Marker ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

Non-Fasting Changes of Hs-CRP Level in Chinese Patients With Coronary Heart Disease After A Daily Meal

2021 ◽  
Author(s):  
Ling Liu ◽  
Qiu-Zhen Lin ◽  
Xue-Yan Zang ◽  
Yan Fu ◽  
Xingyu Wen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
High Sensitivity ◽  
Chinese Patients ◽  
Inflammatory Factor ◽  
Fasting State ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Atherosclerotic Cardiovascular Diseases

Abstract High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory factor in atherosclerotic cardiovascular diseases. In Chinese patients with coronary heart disease (CHD), the changes in hs-CRP levels after a daily meal and the effect of statins on those were never explored. A total of 300 inpatients with CHD were included. Hs-CRP levels were measured in fasting and non-fasting state at 2 hour (h) and 4h after a daily breakfast. Group with fasting hs-CRP ≤ 3mg/L had significantly higher percentage of patients with statins using ≥ 1 month (m) than that with fasting hs-CRP > 3mg/L (51.4% vs. 23.9%, P < 0.05). Hs-CRP levels were significantly higher in non-fasting state (P < 0.05). Interestingly, the hs-CRP didn’t elevate significantly in inpatients with statins using ≥ 1m in hs-CRP > 3mg/L group, but it elevated significantly after meal in inpatients without and with statins using < 1m (P < 0.05). About 32% of patients with non-fasting hs-CRP > 3mg/L came from those with fasting hs-CRP ≤ 3mg/L. In conclusion, hs-CRP levels increased significantly in CHD patients after a daily meal. When fasting hs-CRP > 3mg/L but not ≤ 3mg/L, statins work partly in reducing hs-CRP elevation in non-fasting state.

scholarly journals High-Sensitivity C-Reactive Protein and Coronary Heart Disease in a General Population of Japanese

2008 ◽  
Vol 28 (7) ◽  
pp. 1385-1391 ◽  
Author(s):  
Hisatomi Arima ◽  
Michiaki Kubo ◽  
Koji Yonemoto ◽  
Yasufumi Doi ◽  
Toshiharu Ninomiya ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
General Population ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein

Abstract MP11: Elevated High Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Coronary Heart Disease at Older Age - Atherosclerosis Risk in Communities Study

Circulation ◽  
2013 ◽  
Vol 127 (suppl_12) ◽  
Author(s):  
Seamus Whelton ◽  
Probal Roy ◽  
Brad Astor ◽  
Lin Zhang ◽  
Ron Hoogeveen ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Total Cholesterol ◽  
Serum Cholesterol ◽  
High Sensitivity ◽  
Older Individuals ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Chd Risk ◽  
Hs Crp

Introduction: The relationship between serum cholesterol and coronary heart disease (CHD) risk is attenuated at older age, making it difficult to estimate risk in this age group. Hypothesis: We hypothesized that high sensitivity C-reactive protein (hs-CRP) would identify two subgroups of older individuals (≥65 years): one in whom cholesterol is less predictive of CHD and one in whom it is equally predictive compared to younger individuals. Methods: We calculated crude incident rates per 1,000 person-years and used adjusted Cox proportional hazards models to analyze cholesterol as a predictor of CHD in 8,947 participants with no known history of CHD who were stratified by age (53-64 or 65-75 years) and hs-CRP level (<2 or ≥2 mg/L) at baseline. Results: Among younger participants, total serum cholesterol was significantly associated with an increased risk of CHD regardless of hs-CRP group HR 1.39 (95% CI 1.20-1.61) for hs-CRP <2 mg/L and HR 1.37 (95% CI 1.22-1.53) for hs-CRP ≥2 mg/L. Among older participants with a low hs-CRP, total cholesterol had a similar association with CHD, HR 1.46 (95% CI 1.24-1.71), as in younger individuals. In contrast, among older individuals with higher hs-CRP, the association of CHD with total cholesterol was attenuated, HR 1.14 (95% CI 1.00-1.29), p-value for interaction = 0.02. Similar trends were observed between age groups and hs-CRP categories for LDL cholesterol. Conclusions: Among individuals aged 65-75 years, the association of cholesterol with CHD was strong in those with a low hs-CRP and weak in those with an elevated hs-CRP. Thus, in addition to its use as a risk factor, an elevated hs-CRP could be useful for stratifying the elderly population to aid in the interpretation of serum cholesterol in the prediction of subsequent CHD risk.

Depression, inflammation and coronary heart disease: prognostical value of c reactive protein and depressive symptoms

2011 ◽  
Vol 26 (S2) ◽  
pp. 611-611
Author(s):  
A. Bruschi ◽  
M. Mazza ◽  
D. Harnic ◽  
P. Grandinetti ◽  
C. Battaglia ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Depressive Symptoms ◽  
Statistical Significance ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Cardiac Events ◽  
Reactive Protein ◽  
Increased Risk ◽  
Hs Crp

IntroductionThe aim of this preliminary study is to assess, in a sample of patients with Coronary Heart Disease (CHD), the specific association between depressive symptoms and systemic inflammation.MethodsSixty-One inpatients with CHD, 31 Unstable Angina and 28 Myocardial Infarction, participated in the study. The plasma levels of C Reactive Protein were measured using Dade Behring’s High Sensitivity CRP assay (hs-CRP) at T0, T30 and T90.At the same timings, they were tested by an examiner, unaware of their diagnosis, with a psychometric battery (SCL90-R, HDRS, MADRS, BDI, QlesQ).ResultsThe elevation of hs-CRP occurs during the whole observation period, with maximum significance at T90 (p = 0,031).A multivariate analysis at T0 indicates a statistical correlation between SCL90-R scores and hs-CRP levels (p = 0.02).The SCL90-R is also associated with the risk of further cardiac events (p = 0.013).Also the BDI could be useful as a prognostic factor (p = 0.026).We found a trend towards correlation between CRP values and depressive symptoms, but it never reaches statistical significance for the other scales.ConclusionsThe feelings of loss and the fear of death, related to the environmental and emotional situation of the hospitalization, may prevail in the acute phase of CHDs.Some patients may overcome this reactive depression, while others may exhibit a biological depression, related to the high level of CRP and thus to an increased risk of re-infarction and other coronary events.

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