Non-Fasting Changes of Hs-CRP Level in Chinese Patients With Coronary Heart Disease After A Daily Meal

Abstract High-sensitivity C-reactive protein (hs-CRP) is a key inflammatory factor in atherosclerotic cardiovascular diseases. In Chinese patients with coronary heart disease (CHD), the changes in hs-CRP levels after a daily meal and the effect of statins on those were never explored. A total of 300 inpatients with CHD were included. Hs-CRP levels were measured in fasting and non-fasting state at 2 hour (h) and 4h after a daily breakfast. Group with fasting hs-CRP ≤ 3mg/L had significantly higher percentage of patients with statins using ≥ 1 month (m) than that with fasting hs-CRP > 3mg/L (51.4% vs. 23.9%, P < 0.05). Hs-CRP levels were significantly higher in non-fasting state (P < 0.05). Interestingly, the hs-CRP didn’t elevate significantly in inpatients with statins using ≥ 1m in hs-CRP > 3mg/L group, but it elevated significantly after meal in inpatients without and with statins using < 1m (P < 0.05). About 32% of patients with non-fasting hs-CRP > 3mg/L came from those with fasting hs-CRP ≤ 3mg/L. In conclusion, hs-CRP levels increased significantly in CHD patients after a daily meal. When fasting hs-CRP > 3mg/L but not ≤ 3mg/L, statins work partly in reducing hs-CRP elevation in non-fasting state.

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Abstract MP11: Elevated High Sensitivity C-Reactive Protein as a Risk Marker of the Attenuated Relationship Between Serum Cholesterol and Coronary Heart Disease at Older Age - Atherosclerosis Risk in Communities Study

Circulation ◽

10.1161/circ.127.suppl_12.amp11 ◽

2013 ◽

Vol 127 (suppl_12) ◽

Author(s):

Seamus Whelton ◽

Probal Roy ◽

Brad Astor ◽

Lin Zhang ◽

Ron Hoogeveen ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Total Cholesterol ◽

Serum Cholesterol ◽

High Sensitivity ◽

Older Individuals ◽

C Reactive Protein ◽

Reactive Protein ◽

Chd Risk ◽

Hs Crp

Introduction: The relationship between serum cholesterol and coronary heart disease (CHD) risk is attenuated at older age, making it difficult to estimate risk in this age group. Hypothesis: We hypothesized that high sensitivity C-reactive protein (hs-CRP) would identify two subgroups of older individuals (≥65 years): one in whom cholesterol is less predictive of CHD and one in whom it is equally predictive compared to younger individuals. Methods: We calculated crude incident rates per 1,000 person-years and used adjusted Cox proportional hazards models to analyze cholesterol as a predictor of CHD in 8,947 participants with no known history of CHD who were stratified by age (53-64 or 65-75 years) and hs-CRP level (<2 or ≥2 mg/L) at baseline. Results: Among younger participants, total serum cholesterol was significantly associated with an increased risk of CHD regardless of hs-CRP group HR 1.39 (95% CI 1.20-1.61) for hs-CRP <2 mg/L and HR 1.37 (95% CI 1.22-1.53) for hs-CRP ≥2 mg/L. Among older participants with a low hs-CRP, total cholesterol had a similar association with CHD, HR 1.46 (95% CI 1.24-1.71), as in younger individuals. In contrast, among older individuals with higher hs-CRP, the association of CHD with total cholesterol was attenuated, HR 1.14 (95% CI 1.00-1.29), p-value for interaction = 0.02. Similar trends were observed between age groups and hs-CRP categories for LDL cholesterol. Conclusions: Among individuals aged 65-75 years, the association of cholesterol with CHD was strong in those with a low hs-CRP and weak in those with an elevated hs-CRP. Thus, in addition to its use as a risk factor, an elevated hs-CRP could be useful for stratifying the elderly population to aid in the interpretation of serum cholesterol in the prediction of subsequent CHD risk.

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Depression, inflammation and coronary heart disease: prognostical value of c reactive protein and depressive symptoms

European Psychiatry ◽

10.1016/s0924-9338(11)72318-5 ◽

2011 ◽

Vol 26 (S2) ◽

pp. 611-611

Author(s):

A. Bruschi ◽

M. Mazza ◽

D. Harnic ◽

P. Grandinetti ◽

C. Battaglia ◽

...

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Depressive Symptoms ◽

Statistical Significance ◽

High Sensitivity ◽

C Reactive Protein ◽

Cardiac Events ◽

Reactive Protein ◽

Increased Risk ◽

Hs Crp

IntroductionThe aim of this preliminary study is to assess, in a sample of patients with Coronary Heart Disease (CHD), the specific association between depressive symptoms and systemic inflammation.MethodsSixty-One inpatients with CHD, 31 Unstable Angina and 28 Myocardial Infarction, participated in the study. The plasma levels of C Reactive Protein were measured using Dade Behring’s High Sensitivity CRP assay (hs-CRP) at T0, T30 and T90.At the same timings, they were tested by an examiner, unaware of their diagnosis, with a psychometric battery (SCL90-R, HDRS, MADRS, BDI, QlesQ).ResultsThe elevation of hs-CRP occurs during the whole observation period, with maximum significance at T90 (p = 0,031).A multivariate analysis at T0 indicates a statistical correlation between SCL90-R scores and hs-CRP levels (p = 0.02).The SCL90-R is also associated with the risk of further cardiac events (p = 0.013).Also the BDI could be useful as a prognostic factor (p = 0.026).We found a trend towards correlation between CRP values and depressive symptoms, but it never reaches statistical significance for the other scales.ConclusionsThe feelings of loss and the fear of death, related to the environmental and emotional situation of the hospitalization, may prevail in the acute phase of CHDs.Some patients may overcome this reactive depression, while others may exhibit a biological depression, related to the high level of CRP and thus to an increased risk of re-infarction and other coronary events.

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The Role Of hs-CRP In Predicting The Likelihood Of Coronary Heart Disease

Indonesian Journal of Pharmaceutical and Clinical Research ◽

10.32734/idjpcr.v3i1.4015 ◽

2020 ◽

Vol 3 (1) ◽

pp. 51-61

Author(s):

Nadroh Br Sitepu ◽

Urip Harahap

Keyword(s):

Coronary Heart Disease ◽

Heart Disease ◽

Strong Predictor ◽

High Sensitivity ◽

Vascular Risk ◽

C Reactive Protein ◽

Reactive Protein ◽

Atherosclerotic Lesions ◽

Hs Crp

Coronary Heart Disease (CHD) is a disorder of the cardiovascular system, characterized by atherosclerotic lesions. Inflammation is a strong predictor for coronary heart disease. High sensitivity C-Reactive Protein (hs-CRP) is an important biomarker, synthesized in the liver, can predict the severity of CHD. If the hs-CRP level is found to be low 3 mg / L, a person has the potential for severe vascular risk. Therefore, hs-CRP can be used as a predictor of primary CHD prevention, especially if the hs-CRP level is still low.

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Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

The Indonesian Biomedical Journal ◽

10.18585/inabj.v1i2.94 ◽

2009 ◽

Vol 1 (2) ◽

pp. 51 ◽

Cited By ~ 1

Author(s):

Marissa Arifin ◽

Marsetio Donosepoetro ◽

Sutomo Kasiman

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Glutathione Peroxidase ◽

Medical Center ◽

Oxidized Ldl ◽

C Reactive Protein ◽

Reactive Protein ◽

Significant Difference ◽

Hs Crp

BACKGROUND: Recent clinical studies have suggested that γ-glutamyltransferase (γ-GT) can trigger oxidative stress within the plaque. This study aimed to investigate whether serum γ-GT might be as a risk factor of coronary heart disease (CHD), and measure the associations of serum γ-GT with high sensitive C-Reactive Protein (hs-CRP), Oxidized LDL (Ox-LDL) and Glutathione Peroxidase (GPx).METHODS: This study recruited 48 patients aged 30-70 year who underwent coronary angiography at Haji Adam Malik Medical Center at Medan between February and April 2008 and who presented at least one coronary stenosis of > 50% of the luminar diameter. The sample subjects were consecutively selected.RESULTS: γ-Glutamyltransferase was positively associated (r = 0.546) with hs-CRP as a marker of chronic inflammation after careful adjustment for other established risk factors in CHD patient. But, there was no significant difference between γ-GT in male and female patients. Further, there were no correlations between γ-GT and Ox-LDL and GPx. Ratio of γ-GT/GPx was measured as well, and it was associated with hs-CRP.CONCLUSIONS: Ratio of γ-GT/GPx was associated with inflammation process in coronary heart disease patients.KEYWORDS: γ-glutamyltransferase (γ-GT), inflammation, oxidative stress, coronary heart disease

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