scholarly journals Diagnostic accuracy of Bronchoalveolar lavage fluid in diagnosis of lung cancers in a tertiary care hospital in coastal region of Karnataka

2017 ◽  
Vol 3 (3) ◽  
pp. 322-328
Author(s):  
Dr. Medha Shankarling ◽  
◽  
Dr. Sunil Kumar Y ◽  
Dr. Shetty K Padma ◽  
Dr. Shetty Jayaprakash ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Bronchoalveolar Lavage ◽  
Bronchoalveolar Lavage Fluid ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Coastal Region ◽  
Lavage Fluid ◽  
Care Hospital ◽  
Lung Cancers

scholarly journals 747. Diagnostic Performance of Bronchoalveolar Lavage Fluid Galactomannan Assay in Patients with Negative Serum Galactomannan Assay Suspected with Invasive Pulmonary Aspergillosis

2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S421-S421
Author(s):  
So Yun Lim ◽  
Jinyeong Kim ◽  
Sunghee Park ◽  
Jiwon Jung ◽  
Min Jae Kim ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Diagnostic Performance ◽  
Bronchoalveolar Lavage Fluid ◽  
Diagnostic Yield ◽  
Tertiary Care ◽  
Invasive Pulmonary Aspergillosis ◽  
Lavage Fluid ◽  
Fungal Culture ◽  
Care Hospital ◽  
Pulmonary Aspergillosis

Abstract Background There are limited data in real clinical practice on the diagnostic value of BAL (bronchoalveolar lavage) fluid galactomannan (GM) assay in patients with suspected invasive pulmonary aspergillosis (IPA) who had negative serum GM results. Methods This study was performed at Asan Medical Center, a 2700 bed tertiary-care hospital in Seoul, South Korea between May 2008 and April 2019. All patients with suspected IPA whose serum GM assays revealed negative results and sequentially underwent BAL were enrolled in this study. Patients were classified as proven, probable, possible or not IPA by the revised 2019 EORTC/MSG definition. Results A total of 341 patients with suspected IPA including 4 proven IPA, 38 probable IPA, 107 possible IPA, and 192 not IPA were enrolled. Of these 341 patients, 107 (31%) with possible IPA were excluded from the final analysis. Of 42 patients with proven or probable IPA who had initial negative serum GM results, 24 (57%) revealed positive BAL GM results (n=24) or BAL fungal culture (n=8). Among the remaining 18 (43%), 2 (5%) were diagnosed as proven IPA by the histopathologic exam from transbronchial lung biopsy, 6 (14%) as probable IPA by subsequent sputum fungal culture, and 10 (24%) as probable IPA by repeated serum GM assay after BAL. Of 192 patients with not IPA, 14 (7%) revealed positive BAL GM results (n=14) or BAL fungal culture (n=8). The diagnostic performance of various tests is shown in Table 1. Table 1. Diagnostic performance of various diagnostic tests in patients with suspected IPA who had negative serum GM results Conclusion Sequential BAL in patients with suspected IPA who had initial negative serum GM results provided additional diagnostic yield in about half of patients. Disclosures All Authors: No reported disclosures

scholarly journals Inter-laboratory comparison of three different real-time PCR assays for the detection of Pneumocystis jiroveci in bronchoalveolar lavage fluid samples

2006 ◽  
Vol 55 (9) ◽  
pp. 1229-1235 ◽  
Author(s):  
Catharina F. M. Linssen ◽  
Jan A. Jacobs ◽  
Pieter Beckers ◽  
Kate E. Templeton ◽  
Judith Bakkers ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Real Time ◽  
Real Time Pcr ◽  
Bronchoalveolar Lavage Fluid ◽  
Medical Center ◽  
Tertiary Care ◽  
Lavage Fluid ◽  
The Other ◽  
Pneumocystis Jiroveci ◽  
Pcr Assays

Pneumocystis jiroveci pneumonia (PCP) is an opportunistic infection affecting immunocompromised patients. While conventional diagnosis of PCP by microscopy is cumbersome, the use of PCR to diagnose PCP has great potential. Nevertheless, inter-laboratory validation and standardization of PCR assays is lacking. The aim of this study was to evaluate the inter-laboratory agreement of three independently developed real-time PCR assays for the detection of P. jiroveci in bronchoalveolar lavage fluid samples. Therefore, 124 samples were collected in three tertiary care laboratories (Leiden University Medical Center, Maastricht Infection Center and Radboud University Nijmegen Medical Centre) and were tested by both microscopy and real-time PCR. Of 41 samples positive for P. jiroveci by microscopy, 40 were positive in all three PCR assays. The remaining sample was positive in a single assay only. Out of 83 microscopy-negative samples, 69 were negative in all three PCR assays. The other 14 samples were found positive, either in all three assays (n=5), in two (n=2) or in one of the assays (n=7). The data demonstrate high inter-laboratory agreement among real-time PCR assays for the detection of P. jiroveci.

Utility of bronchoalveolar lavage in cytology; a study at tertiary care hospital

2014 ◽  
Vol 1 (4) ◽  
pp. 362-364
Author(s):  
V. M Bhagat ◽  
◽  
Hemali J Tailor ◽  
Prashant R. Patel ◽  
Mayur Adajania ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Care Hospital

Clinico-morphological Correlation and Diagnostic Accuracy of Synovial Biopsy in Synovitis: Experience in Tertiary Care Hospital

2017 ◽  
Vol 6 (2(Part-1)) ◽  
pp. 183-189
Author(s):  
Bhuvanamha Devi Ramamurthy ◽  
◽  
Kalaivani Amitkumar ◽  
Shivashekar Ganapathy ◽  
C.D. Anand ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Synovial Biopsy ◽  
Care Hospital ◽  
Morphological Correlation

scholarly journals Cellular Profiles of Bronchoalveolar Lavage Fluid and Their Prognostic Significance for Non-HIV-Infected Patients with Pneumocystis jirovecii Pneumonia

2015 ◽  
Vol 53 (4) ◽  
pp. 1310-1316 ◽  
Author(s):  
Ju Young Lee ◽  
Hyun Jung Park ◽  
Yong Kyun Kim ◽  
Shinae Yu ◽  
Yong Pil Chong ◽  
...  
Keyword(s):  
Bronchoalveolar Lavage ◽  
Tertiary Care ◽  
Prognostic Significance ◽  
Lavage Fluid ◽  
Pneumocystis Jirovecii ◽  
Pneumocystis Jirovecii Pneumonia ◽  
Care Hospital ◽  
Median Percentage ◽  
Content Type ◽  
Cellular Analysis

The usefulness of bronchoalveolar lavage (BAL) fluid cellular analysis in non-human immunodeficiency virus (HIV)-infected patients withPneumocystis jiroveciipneumonia (PCP) has not been adequately evaluated. The objective of this study was to analyze the cellular profiles of BAL fluid and to evaluate their prognostic significance in non-HIV-infected patients with PCP. A 7-year retrospective cohort study of 166 non-HIV-infected adult patients with PCP who underwent BAL was performed in a tertiary care hospital. The median total BAL fluid white blood cell count was 180/μl (interquartile range, 80 to 330) and was unaffected by the severity of PCP. The median percentages of BAL fluid neutrophils, lymphocytes, and alveolar macrophages were 13.1%, 31.7%, and 30.2%, respectively. The median percentage of BAL fluid neutrophils was significantly higher in severe than in mild-to-moderate PCP (20.4% versus 6.0%,P< 0.001), as was the absolute neutrophil count (24/μl versus 13/μl,P= 0.001). The percentage of BAL fluid neutrophils was an independent predictor of 30-day (adjusted odds ratio [aOR], 1.02; 95% confidence interval [CI], 1.01 to 1.03) and 60-day (aOR, 1.02; 95% CI, 1.01 to 1.04) mortalities. The 30-day and 60-day mortalities increased at rates of 15% (P= 0.006) and 21% (P< 0.001) per 10% increment of BAL fluid neutrophil levels, respectively. The degree of BAL fluid pleocytosis was relatively low without regard to the severity of PCP. The percentage of BAL fluid neutrophils can be used as a prognostic marker in non-HIV-infected patients with PCP.

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