scholarly journals THE INCIDENCE OF MEASLES IN THE KYRGYZ REPUBLIC DURING THE COVID-19 CORONAVIRUS INFECTION PANDEMIC

2021 ◽  
pp. 30-37
Author(s):  
Zh.I. Makembaeva
Keyword(s):  
Kyrgyz Republic ◽  
Coronavirus Infection

scholarly journals Symptoms, Features of Diagnosis and Preventive Measures During the “Second Wave” COVID-19 in Residents of the Kyrgyz Republic

2021 ◽  
Vol 7 (4) ◽  
pp. 164-175
Author(s):  
Sh. Sulaimanov ◽  
Zh. Esenalieva
Keyword(s):  
Large Scale ◽  
Preventive Measures ◽  
Kyrgyz Republic ◽  
Social Changes ◽  
Intellectual Work ◽  
X Ray ◽  
Coronavirus Infection ◽  
Spread Of Infection ◽  
Second Wave ◽  
Muscle Ache

The results of our study show that the respondent’s perception of large-scale social changes associated with the pandemic of the new coronavirus infection in the Kyrgyz Republic has a number of features. A sufficient level of awareness of the respondents about the symptoms of the disease, the ways of transmission of the virus, and measures to prevent the spread of infection are combined with an underestimation of the situation (17.2%). The majority (66.6%) of the respondents lived in Bishkek. The survey was held among 247 people, most of whom were women (57.3%) and young people (35.9±14.9 years). Every fourth participant in the study is a chronic tobacco smoker (24%). Less than half (47.3%) of the respondents were engaged in intellectual work. Among the respondents, the most common symptoms of COVID-19 were loss of taste or smell, fever, headache, muscle ache, cough, sore throat. Every third (28.4%) respondent was referred to an X-ray, CT scan. PCR and ELISA studies were carried out, respectively, by 22.5% and 10.9%.

scholarly journals Experience in Using Antiviral Agents for the Treatment of Novel Coronavirus Infection (COVID-19) in Kyrgyzstan

2021 ◽  
Vol 9 (4) ◽  
pp. 191-199
Author(s):  
A. A. Zurdinova ◽  
A. Z. Kutmanova
Keyword(s):  
General Condition ◽  
Clinical Guidelines ◽  
Treatment Duration ◽  
Clinical Decision Making ◽  
Antiviral Agents ◽  
Statistical Processing ◽  
National Guideline ◽  
Kyrgyz Republic ◽  
Coronavirus Infection ◽  
Novel Coronavirus

The national clinical guidelines for the treatment of novel coronavirus infection (COVID-19) are the main source of information and the reference point for clinical decision-making by healthcare professionals in the Kyrgyz Republic. The recommendations presented in these documents are largely based on data from real clinical practice, but the efficacy and safety of a number of antiviral agents, the indications for which have been expanded to include COVID-19 treatment, remain unclear.The aim of the study was to conduct a retrospective pharmacoepidemiological analysis of lopinavir+ritonavir use in hospitals in the Kyrgyz Republic for the treatment of COVID-19 during the period from March until April 2020.Materials and methods: the paper describes a retrospective study of 145 medical records of patients with confirmed COVID-19 who were hospitalized in infectious disease departments/hospitals of the Kyrgyz Republic. Statistical processing was performed using Microsoft Excel 2017.Results: between 16 March 2020 and 25 April 2020, 145 patients were prescribed lopinavir+ritonavir at a dose of 200 mg + 50 mg, 2 tablets twice a day—in line with the dosage regimen recommended by the national guideline. The national guideline recommended the treatment duration of 10 days, while the actual treatment duration was 1–12 days (5.5 days on average) depending on the tolerability of the drug. The use of the drug was accompanied by adverse drug reactions (ADRs) in 78 patients (53.8%), and caused deterioration in the general condition of 73 of these patients (94.8%) which resulted in discontinuation of the drug. The most common ADRs were nausea, vomiting, diarrhoea, decreased appetite, yellowness of the skin, and, according to laboratory studies, an increase in serum levels of bilirubin, creatinine, glucose, aspartate aminotransferase and amylase activity. A retrospective assessment of the causal relationship probability according to the Naranjo scale showed an interrelation between the use of lopinavir+ritonavir and ADR development.Conclusions: the use of the lopinavir+ritonavir drug in COVID-19 patients led to deterioration of their general condition, which was severe in some cases. The data obtained indicate that the use of this drug for COVID-19 treatment is clinically unreasonable and irrational. Lopinavir+ritonavir was excluded from subsequent revisions of the clinical guidelines for the diagnosis and treatment of COVID-19 in the Kyrgyz Republic.

scholarly journals Molecular Diagnostics of Coronavirus Infection in the Kyrgyz Republic

2020 ◽  
pp. 141-143
Author(s):  
S. V. Khegay ◽  
A. K. Dzhaparova ◽  
E. M. Dushenalieva ◽  
B. Kalmyrzaev ◽  
K. T. Kasymbekova ◽  
...  
Keyword(s):  
Molecular Diagnostics ◽  
Test Tube ◽  
Kyrgyz Republic ◽  
Single Test ◽  
Average Deviation ◽  
Transport Medium ◽  
Test Systems ◽  
Nasal Swabs ◽  
Sample Pooling ◽  
Coronavirus Infection

Abstract. Objective of the study was to develop an effective method of sample pooling for the detection of SARSCoV-2 coronavirus RNA using PCR and evaluate that approach with various test systems.Materials and methods. SARS-CoV-2 coronavirus RNA was detected in samples containing nasal swabs placed in a transport medium. 5 samples were combined into one pool to perform the analysis. The effectiveness of the “in single test tube” pooling method for performing mass studies for COVID-19 was evaluated using the Vector-PCRrv-2019-nCoV-RG-19 test systems,Russia; “ArtTest COVID-19”,Belarus; “BioSpeedy”,Turkey.Results and discussion. A total of 587 pools were studied, consisting of 2935 test samples, in which 56 samples containing SARS-CoV-2 RNA were detected and confirmed by PCR. When studying the method of pooling samples, its specificity and optimal sensitivity for detecting SARS-CoV-2 RNA using the Vector-PCRrv-2019-nCoV-RG, ArtTest COVID-19, and BioSpeedy test systems were shown. The results of applying the pooling method correlated with the data obtained without pooling samples. The average deviation of the cycle amounted to 2 Ct; the fluorescence curve of positive samples corresponded to the «S» form.

Epidemiological features of the incidence of COVID-19 in the Jalal-Abad region of the Kyrgyz Republic

2021 ◽  
pp. 38-46
Author(s):  
Nemat Moidunovich Temirov ◽  
Begimai Toktobolotovna Abdimomunova ◽  
Vazira Nematovich Temirova ◽  
Parikhan Zalimtoroevna Eshenkulova ◽  
Saparbai Tezekbaevich Zholdoshev ◽  
...  
Keyword(s):  
Adult Population ◽  
Main Role ◽  
Kyrgyz Republic ◽  
Laboratory Studies ◽  
Epidemiological Analysis ◽  
Moderate Severity ◽  
Epidemiological Features ◽  
Coronavirus Infection ◽  
The Moment ◽  
The City

In order to identify the epidemiological features of the incidence of COVID-19 in the Jalal-Abad region of the Kyrgyz Republic, a retrospective epidemiological analysis was carried out, according to the results of which the following was established. Jalal-Abad region was the leader in the number of cases of new coronavirus infection in the Kyrgyz Republic in 2020. The incidence had a pronounced rise with a maximum in October. The most disadvantaged in this period in terms of the incidence of a new coronavirus infection were Mailuu-SUU (1663.2 per 100 thousand), Chatkal (1000.8 per 100 thousand), Jalal-Abad (677.6 per 100 thousand) and Kara-Kol (532.0 per 100 thousand). In all territorial entities of the region, cases of COVID-19 were registered mainly among the adult population. The diseases of the new coronavirus infection in children were isolated. The greatest proportion of cases occurred in people aged 30–64 years, which is due to the larger number of this group, as well as the most severe course of the disease. Most often, the diseases occurred in the form of moderate severity (47.2 %) and mild (22.7 %). At the same time, according to the results of laboratory studies, it was possible to identify 14.9 % of cases of the disease with an asymptomatic course. The condition was regarded as severe in 12.2 % of cases, extremely severe — in 3 %. High focality was revealed. The share of foci with two cases was 63.2 %, with three — 19.3 %, four — 6.2 %, five — 5.5 %, six or more — 5.8 %. Most foci with four or more cases were registered in Ala-Buka, Suzak, Toktogul, Nooken districts and the city of Tash-Komur. The study made it possible to identify the features of the course of the epidemic process of a new coronavirus infection, which made it possible to adjust the implementation of preventive and anti-epidemic measures in the future, to reduce the rate of focality, to minimize mortality. At the same time, the main role in the prevention of COVID-19 from the moment of registration of vaccines against this infection is assigned to specific prevention.

scholarly journals The Impact of COVID-19 on the Confectionery of the Kyrgyz Republic

2021 ◽  
Vol 7 (6) ◽  
Author(s):  
A. Kydygalieva
Keyword(s):  
Life Expectancy ◽  
Small Businesses ◽  
Kyrgyz Republic ◽  
The Past ◽  
Financial Condition ◽  
Market Shares ◽  
The World ◽  
Coronavirus Infection ◽  
Main Factors ◽  
The Impact

The coronavirus infection has been continuing to spread all around the world for a year and a half. And it has had an impact not only on the health and life expectancy of the population, but also on the overall psychological and financial condition of people all around the world. The Kyrgyz Republic was no exception to this. Because, unfortunately, tons of employees lost their jobs during the quarantine. The competition killed most part of small businesses. The same situation was in the confectionery market of Kyrgyzstan. This article examines the main companies in the confectionery market of Kyrgyzstan, their market shares, as well as the volume of imported products over the past 8 years. Also the paper shows the main factors that influenced the indicators of confectionery consumption and changes in the companies management structure during the pandemic.

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Kardiologiia ◽  
2021 ◽  
Vol 61 (9) ◽  
pp. 20-32
Author(s):  
E. I. Tarlovskaya ◽  
A. G. Arutyunov ◽  
A. O. Konradi ◽  
Yu. M. Lopatin ◽  
A. P. Rebrov ◽  
...  
Keyword(s):  
Lower Risk ◽  
Inhaled Corticosteroids ◽  
Oral Anticoagulants ◽  
Fatal Outcome ◽  
Chronic Obstructive ◽  
Imaging Features ◽  
Kyrgyz Republic ◽  
Antihyperglycemic Therapy ◽  
Coronavirus Infection ◽  
The Republic

Aim      To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods  The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).Results The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion      In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity. 

The prevalence of coronavirus infection of cats in megapolis

2019 ◽  
Vol 332 (9) ◽  
pp. 16-19
Author(s):  
A.A. Shabeikin ◽  
◽  
A.D. Filimonova ◽  
A.V. Parshikova ◽  
T.E. Shashurina ◽  
...  
Keyword(s):  
Coronavirus Infection

Experience in Applying Hyperbaric Oxygen Therapy Using Portable Pressure Chambers for the Treatment of Patients with the Novel Coronavirus Infection COVID-19

Biomeditsina ◽  
2020 ◽  
pp. 39-46
Author(s):  
A. S. Samoilov ◽  
Yu. D. Udalov ◽  
M. V. Sheyanov ◽  
A. V. Gholinsky ◽  
A. B. Litvinenko
Keyword(s):  
Oxygen Saturation ◽  
Hyperbaric Oxygen ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Capillary Blood ◽  
Blood Hemoglobin ◽  
Patient Groups ◽  
Radiological Changes ◽  
Coronavirus Infection ◽  
Novel Coronavirus

This communication presents the experience of using mobile pressure chambers in patients with the confi rmed novel coronavirus infection in hospital settings. The obtained preliminary results indicate positive antihypoxic effects of hyperbaric oxygen therapy (HBO) applied in the form of increased saturation. After a session of HBO, patients demonstrated an increase in the oxygen saturation of capillary blood hemoglobin at the average level of 3.71 points. Differences between SatO2 levels prior to and following HBO treatment were signifi cant in the CT2, CT3 and CT4 groups (p0.05). As expected, the effi cacy of HBO in terms of the oxygen saturation of capillary blood hemoglobin was the greatest in the patient groups showing pronounced clinical and radiological changes in the lungs.

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