scholarly journals Neuroprotective Efficacy of A Combination of Fish Oil and Bacopa Monnieri Against 3-Nitropropionic Acid Induced Oxidative Stress in Rats

2017 ◽  
Vol 3 (2) ◽  
pp. 349-357
Author(s):  
Denny Joseph Manual Kollareth ◽  
◽  
Muralidhara
Keyword(s):  
Oxidative Stress ◽  
Fish Oil ◽  
Bacopa Monnieri ◽  
Nitropropionic Acid ◽  
Neuroprotective Efficacy ◽  
3 Nitropropionic Acid

Neuroprotective efficacy of a combination of fish oil and ferulic acid against 3-nitropropionic acid-induced oxidative stress and neurotoxicity in rats: behavioural and biochemical evidence

2014 ◽  
Vol 39 (4) ◽  
pp. 487-496 ◽  
Author(s):  
Denny Joseph K.M. ◽  
Muralidhara
Keyword(s):  
Oxidative Stress ◽  
Fish Oil ◽  
Ferulic Acid ◽  
Cytosolic Calcium ◽  
Brain Regions ◽  
Male Rats ◽  
Activity Levels ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

The beneficial effects of fish oil (FO) supplements on the central nervous system have been adequately demonstrated. However, FO supplementation at higher doses for longer duration is likely to cause oxidative stress in vivo. To overcome this, attempts have been made to enrich FO with known antioxidants/phytochemicals. In the present study, we examined the hypothesis that a combination of FO with ferulic acid (FA), a naturally occurring phenolic compound, is likely to provide higher degree of neuroprotection. This was examined by employing 3-nitropropionic acid (NPA), a well-known neurotoxin used to mimic behavioural and neurochemical features of Huntington’s disease. Growing male rats administered with NPA (25 mg/kg of body weight (bw) for 4 days) were provided with either FO (2 mL/kg bw), FA (50 mg/kg bw) or FO+FA for 2 weeks. Interestingly, FO+FA not only offered significant protection against NPA-induced behavioural impairments, but also markedly attenuated oxidative stress in brain regions (striatum/cerebellum) as evidenced by the reduction in reactive species, malondialdehyde, hydroperoxides and nitric oxide (NO) levels. Further, FO+FA combination restored the activities of various antioxidant enzymes and the levels of cytosolic calcium. In striatum, activity levels of acetylcholinesterase enzyme and dopamine levels were markedly restored among FO+FA rats. Interestingly, NPA-induced mitochondrial dysfunctions were also attenuated among FO+FA rats. Collectively, our findings suggest the advantage of co-treatment of FO with known antioxidants to achieve a higher therapeutic benefit in the treatment of oxidative stress-mediated neurodegenerative conditions.

Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons

2018 ◽  
Vol 46 (1) ◽  
pp. 751-762 ◽  
Author(s):  
Dirleise Colle ◽  
Danúbia Bonfanti Santos ◽  
Viviane de Souza ◽  
Mark William Lopes ◽  
Rodrigo Bainy Leal ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cortical Neurons ◽  
Sodium Selenite ◽  
Primary Cortical Neurons ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Piroxicam attenuates 3-nitropropionic acid-induced brain oxidative stress and behavioral alteration in mice

2014 ◽  
Vol 24 (9) ◽  
pp. 672-678 ◽  
Author(s):  
Jadiswami C ◽  
Megha H. M ◽  
Shivsharan B. Dhadde ◽  
Sharanbasappa Durg ◽  
Pandharinath P. Potadar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Behavioral Alteration ◽  
Nitropropionic Acid ◽  
Brain Oxidative Stress ◽  
3 Nitropropionic Acid

Treatment with Dehydroepiandrosterone Prevents Oxidative Stress Induced by 3-Nitropropionic Acid in Synaptosomes

Pharmacology ◽  
2005 ◽  
Vol 74 (3) ◽  
pp. 113-118 ◽  
Author(s):  
Isaac Túnez ◽  
M. Carmen Muñoz ◽  
Pedro Montilla
Keyword(s):  
Oxidative Stress ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid

Evaluation of 3-nitrotyrosine as a marker for 3-nitropropionic acid-induced oxidative stress in Lewis and Wistar rats and strain-specific whole brain spheroid cultures

2002 ◽  
Vol 931 (1) ◽  
pp. 5-20 ◽  
Author(s):  
Charlotte E Teunissen ◽  
Marjanne Markerink-van Ittersum ◽  
Chris de Bruijn ◽  
Harry W.M Steinbusch ◽  
Jan de Vente
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Whole Brain ◽  
Nitropropionic Acid ◽  
3 Nitropropionic Acid
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