The Study of the Properties of Long-Term Electronic Archival Information Storage on Optical Disks Organized into a Structure of RAID-5

The introduction and active use of information transmission and storage systems in the Ministry of Defense (MoD) of Ukraine form the need to develop ways of guaranteed removal of data from media after their use or long-term storage. Such a task is an essential component of the functioning of any information security system. The article analyzes the problems of guaranteed destruction of information on magnetic media. An overview of approaches to the guaranteed destruction of information on magnetic media of different types is presented, and partial estimates of the effectiveness of their application are given by some generally accepted indicators of performance evaluation. The article also describes the classification of methods of destruction of information depending on the influence on its medium. The results of the analysis revealed the main problems of application of software methods and methods of demagnetization of the information carrier. The issue of guaranteed destruction of information from modern SSD devices, which are actively used in the formation of new systems of information accumulation and processing, became particularly relevant in the article. In today's conditions of development of the Armed Forces of Ukraine, methods of mechanical and thermal destruction are more commonly used today. In the medium term, the vector of the use of information elimination methods will change towards the methods of physical impact by the pulsed magnetic field and the software methods that allow to store the information storage device, but this today requires specialists to develop new ways of protecting information in order to avoid its leakage.

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An Endogenous RNA Transcript Antisense to CNGα1 Cation Channel mRNA

Molecular Biology of the Cell ◽

10.1091/mbc.e02-03-0127 ◽

2002 ◽

Vol 13 (10) ◽

pp. 3696-3705 ◽

Cited By ~ 6

Author(s):

Chin-Hung Cheng ◽

David Tai-Wai Yew ◽

Hiu-Yee Kwan ◽

Qing Zhou ◽

Yu Huang ◽

...

Keyword(s):

Expression System ◽

Expression Patterns ◽

Long Term Potentiation ◽

Information Storage ◽

Term Potentiation ◽

Hippocampal Ca1 ◽

Oocyte Expression System ◽

Neuronal Functions ◽

Rna Transcript

CNG channels are cyclic nucleotide-gated Ca2+-permeable channels that are suggested to be involved in the activity-dependent alterations of synaptic strength that are thought to underlie information storage in the CNS. In this study, we isolated an endogenous RNA transcript antisense to CNGα1 mRNA. This transcript was capable of down-regulating the expression of sense CNGα1 in theXenopus oocyte expression system. RT-PCR, Northern blot, and in situ hybridization analyses showed that the transcript was coexpressed with CNGα1 mRNA in many regions of human brain, notably in those regions that were involved in long-term potentiation and long-term depression, such as hippocampal CA1 and CA3, dentate gyrus, and cerebellar Purkinje layer. Comparison of expression patterns between adult and fetal cerebral cortex revealed that there were concurrent developmental changes in the expression levels of anti-CNG1 and CNGα1. Treatment of human glioma cell T98 with thyroid hormone T3 caused a significant increase in anti-CNG1 expression and a parallel decrease in sense CNGα1 expression. These data suggest that the suppression of CNGα1 expression by anti-CNG1 may play an important role in neuronal functions, especially in synaptic plasticity and cortical development. Endogenous antisense RNA-mediated regulation may represent a new mechanism through which the activity of ion channels can be regulated in the human CNS.

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Astrocytic microdomains from mouse cortex gain molecular control over long-term information storage and memory retention

Communications Biology ◽

10.1038/s42003-021-02678-x ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Beatrice Vignoli ◽

Gabriele Sansevero ◽

Manju Sasi ◽

Roberto Rimondini ◽

Robert Blum ◽

...

Keyword(s):

Information Storage ◽

Memory Retention ◽

The Novel ◽

Behavioral Test ◽

Molecular Control ◽

Mouse Cortex ◽

Memory Circuits ◽

Initial Activation ◽

Synaptic Changes

AbstractMemory consolidation requires astrocytic microdomains for protein recycling; but whether this lays a mechanistic foundation for long-term information storage remains enigmatic. Here we demonstrate that persistent synaptic strengthening invited astrocytic microdomains to convert initially internalized (pro)-brain-derived neurotrophic factor (proBDNF) into active prodomain (BDNFpro) and mature BDNF (mBDNF) for synaptic re-use. While mBDNF activates TrkB, we uncovered a previously unsuspected function for the cleaved BDNFpro, which increases TrkB/SorCS2 receptor complex at post-synaptic sites. Astrocytic BDNFpro release reinforced TrkB phosphorylation to sustain long-term synaptic potentiation and to retain memory in the novel object recognition behavioral test. Thus, the switch from one inactive state to a multi-functional one of the proBDNF provides post-synaptic changes that survive the initial activation. This molecular asset confines local information storage in astrocytic microdomains to selectively support memory circuits.

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