scholarly journals Quality of life and its determinants in patients with drug resistant focal epilepsy

2021 ◽  
Vol 12 (4) ◽  
pp. 216-225
Author(s):  
S. М. Malyshev ◽  
Т. М. Alekseeva
Keyword(s):  
Quality Of Life ◽  
Social Status ◽  
Depressive Disorders ◽  
Focal Epilepsy ◽  
Multiple Linear Regression Model ◽  
Epileptic Seizures ◽  
Drug Resistant ◽  
Severity Scale ◽  
Pronounced Decrease

Objective: to determine the factors influencing quality of life (QoL) in patients with drug-resistant focal epilepsy (DRFE). Material and methods. 111 adult patients with DRFE were included in the study. Quality of life was measured using the Quality Of Life In Patients with Epilepsy – 31 questionnaire (QOLIE-31). The severity of the disease (frequency and subjective assessment of the severity of seizures), the effect of pharmacotherapy (drug load and composition of the treatment regimen), the social status of patients, comorbid conditions (anxiety and depressive disorders, pathological fatigue) were assessed. Results. In the studied sample, a pronounced decrease in QoL was shown, the median of the final QOLIE-31 score was 65.4 points (interquartile range 53.0–72.6 points). A statistically significant decrease in QoL was found in subgroups of patients with seizures during the previous three months; taking carbamazepine or benzobarbital; with anxiety and depressive disorders; with pathological fatigue; and in unemployed patients. A multiple linear regression model (R2=0.66) was developed, which included the following determinants: Fatigue Severity Scale, Liverpool Seizure Severity Scale, and the risk of depression according to the NDDI-E questionnaire. Conclusion. In patients with drug-resistant focal epilepsy, there is a pronounced decrease in the quality of life due to combination of factors associated with the characteristics of the disease, treatment, comorbidities, and social status. The key QoL determinants in patients with DRFE are pathological fatigue, anxiety and depression, and subjective severity of epileptic seizures; employment is a positive factor. The role of epileptic seizures frequency in QoL formation in these patients requires further research.

The impact of perampanel treatment on quality of life and psychiatric symptoms in patients with drug-resistant focal epilepsy: An observational study in Italy

2019 ◽  
Vol 99 ◽  
pp. 106391 ◽  
Author(s):  
Francesco Deleo ◽  
Rui Quintas ◽  
Katherine Turner ◽  
Giuseppe Didato ◽  
Elena Zambrelli ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Observational Study ◽  
Psychiatric Symptoms ◽  
Focal Epilepsy ◽  
Drug Resistant ◽  
The Impact

Features of affective disorders correction in patients with epilepsy (therapy, rehabilitation, prevention)

2021 ◽  
Vol 90 (1) ◽  
pp. 52-61
Author(s):  
H. Kozhyna ◽  
I. Strelnikova ◽  
M. Khaustov
Keyword(s):  
Quality Of Life ◽  
Affective Disorders ◽  
Depressive Disorders ◽  
Epileptic Seizures ◽  
Psychosocial Adaptation ◽  
Keywords Epilepsy ◽  
Constant Attention ◽  
Clinical Prognosis ◽  
Patients With Epilepsy

For many decades, epilepsy has remained a serious medical and social problem that requires constant attention not only from neurologists, psychiatrists, but also from medical psychologists and social workers. The priority in the treatment of epilepsy is not only to prevent seizures, but also to help the patient maintain social functioning and restore quality of life. Achieving drug remission of epileptic seizures is only part of the management of the disease, it is necessary to help restore the patient's psychosocial adaptation and form a correct understanding of their disease and related limitations in daily functioning. A comprehensive examination which involved 65 patients with epilepsy of both sexes aged 18–40 years was conducted in compliance with the principles of bioethics and medical deontology. The mean age of the subjects ranged from (34.0±1.6) years, duration of the disease in patients did not exceed 10 years. All subjects had disorders of the emotional sphere of non-psychotic level, which were recorded in the interictal period of the disease. Selected comprehensive system of correction of affective disorders in patients with epilepsy helped to achieve following results, especially: reduction of anxiety and depressive disorders (73.5 %), reducing the level of motor and ideational inhibition (65.2 %), reducing the intensity and duration of depressive affect (72.5 %), restoration of interest in activities that previously interested patients (69.5 %), improvement of psychosocial adaptation (81.3 %), managed to achieve the transition of maladaptive types of attitudes to the disease to adaptive (66.5 %) and improve quality of life (83.2 %). A study of affective disorders in patients with epilepsy allowed us to make following conclusions: epilepsy is often combined with affective disorders. Depressive disorders are more common among all affective disorders. Epilepsy and affective disorders interact with each other and complicate clinical prognosis. Keywords: epilepsy, affective disorders, rehabilitation, psychoeducation.

Determinants of quality of life in patients with drug-resistant focal epilepsy

2019 ◽  
Vol 100 ◽  
pp. 106525 ◽  
Author(s):  
Bruno Silva ◽  
Hugo Canas-Simião ◽  
Susana Cordeiro ◽  
Ana Velosa ◽  
Albino J. Oliveira-Maia ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Focal Epilepsy ◽  
Drug Resistant

The beneficial effect of probiotics as a supplementary treatment in drug-resistant epilepsy: a pilot study

2018 ◽  
Vol 9 (6) ◽  
pp. 875-881 ◽  
Author(s):  
M. Gómez-Eguílaz ◽  
J.L. Ramón-Trapero ◽  
L. Pérez-Martínez ◽  
J.R. Blanco
Keyword(s):  
Quality Of Life ◽  
Epileptic Seizures ◽  
Drug Resistant ◽  
Intention To Treat ◽  
Before And After ◽  
Drug Resistant Epilepsy ◽  
A Prospective Study ◽  
Therapeutic Alternatives ◽  
Treat Analysis

Epilepsy is a neurological disease with high global prevalence. Despite the range of drug-based treatments currently available to control the condition, one in 3 patients experiences epileptic seizures. Therapeutic alternatives for these patients include the ketogenic diet, surgery or the cerebral implantation of neurostimulators; however these are benefits with limits. The target of this study is to find a new complementary treatment for these patients, studying the effectiveness of probiotics for controlling epileptic seizures in patients with drug-resistant epilepsy. A prospective study was designed in which a group of patients with drug-resistant epilepsy was administered a probiotic mixture for 4 months. Patients were assessed before and after taking the probiotics; among other variables, number of seizures and patients’ quality of life (QOLIE-10) were monitored. Levels of cD-14, interleukin 6, and γ-aminobutyric acid were also analysed throughout the study. 45 patients were included in the study. In an intention-to-treat analysis, 28.9% of all patients displayed a greater than 50% reduction in the number of seizures (the parameter required in clinical trials). A significant improvement was also observed in patients’ quality of life. We found that probiotics may be an option for supplementary therapy. Since the use of probiotics is safe, they may contribute to improving seizure control, and therefore quality of life, in patients with drug-resistant epilepsy. The study has been registered in https://clinicaltrials.gov with number NCT03403907.

scholarly journals Patients with resistant focal epilepsy: what affects the quality of life?

2019 ◽  
Vol 11 (3) ◽  
pp. 233-243
Author(s):  
K. V. Firsov ◽  
M. G. Amirhanyan ◽  
A. S. Kotov
Keyword(s):  
Quality Of Life ◽  
Focal Epilepsy ◽  
Brain Mri ◽  
Epileptic Seizures ◽  
Social Situation ◽  
Psychological State ◽  
Treatment Resistant ◽  
History Of ◽  
The Impact

The aim is to assess the impact of resistant focal epilepsy on the quality of patients' life.Materials and methods. Prospective, comparative, observational study conducted under conditions of real clinical practice. Inclusion criteria: age over 18 years; the presence of two or more epileptic seizures in history; a long history of treatment-resistant focal epileptic seizures; current AED therapy. Exclusion criteria: history of non-epileptic seizures of any etiology; inability to perform an MRI and/or EEG. The design included two patient visits, the second 3-12 months after the first ("primary" and "repeated" examinations). The examination included the medical history, analysis of seizure diary, clinical and neurological examination, routine EEG and/or EEG video monitoring, brain MRI, and laboratory tests. During the initial and repeated visits, the patients were asked to answer the QOLIE-31, NHS3, HADS questionnaires. The patients were also asked to give their own subjective assessment of their physical and psychological state, treatment results, side effects, social situation, and the quality of life. All patients had a follow-up history of at least one year.Results. In total, 120 patients with current or past treatment-resistant epileptic seizures were examined (53 men and 67 women aged 18 to 77 years). At the time of the re-examination (under continuing AED therapy), seizures stopped in 50.8% of them. The number of seizure types decreased in 65.9% of people. The effect of resistant focal epilepsy on the patient's quality of life was determined.Conclusion. The use of commonly accepted tests (QOLIE-31, HADS, etc.) in the "expertise" mode is incorrect, probably because these tests had been originally created for the "client" situation. A discrepancy was found between an objective improvement in the clinical picture as a result of successful treatment and a subjective "insignificant" improvement in the quality of life as per patients' assessments.

scholarly journals Capacities of formal methods in objectivization of epileptic severity dynamics

1997 ◽  
Vol XXIX (1-2) ◽  
pp. 30-33
Author(s):  
V. A. Karlov ◽  
P. N. Vlasov ◽  
А. О. Khabibova
Keyword(s):  
Quality Of Life ◽  
Epileptic Seizures ◽  
Severity Scale ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Temporal Epilepsy ◽  
Epileptic Patients ◽  
Therapy Quality ◽  
Index Of Quality

There was analyzed dynamics of morbidity in 65 epileptic patients with the help of severity scale of epileptic seizures, accounting method of recovering percentage, index of quality of life. The highest value on scale was obtained during complex partial seizures, transferring into secondly generalized (15 points), the lowest during typical absentia epileptica (1 point). When mixing some epileptic seizures the total sum of points achieved 34 points. Percentage of improvements was counted in 6 months after correction of therapy. Quality of life was evaluated by 5-point analogue scale, developed by the authors and tested in temporal epilepsy.

Psychiatric disorders, depression and quality of life in patients with psychogenic non-epileptic seizures and drug resistant epilepsy living in Argentina

Seizure ◽  
2021 ◽  
Vol 92 ◽  
pp. 174-181
Author(s):  
Laura Scévola ◽  
Camila Wolfzun ◽  
Mercedes Sarudiansky ◽  
María Marta Areco Pico ◽  
Micaela Ponieman ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Psychiatric Disorders ◽  
Epileptic Seizures ◽  
Drug Resistant ◽  
Drug Resistant Epilepsy

Anxiety-depressive disorders and quality of life in patients with atrial fibrillation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
T Demenko ◽  
G.A Chumakova
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Atrial Fibrillation ◽  
Correlation Analysis ◽  
Depressive Disorders ◽  
Life Assessment ◽  
Mild Depression ◽  
Group 2 ◽  
Group 1

Abstract Background Mental disorders in patients with cardiovascular disease have a significant impact on the course, the prognosis of the underlying disease and quality of life (QOL). Objective We aimed to examine the prevalence of anxiety and depressive disorders and their impact on the quality of life in patients with atrial fibrillation (AF). Materials and methods In 52 with permanent AF and 50 with paroxysmal AF patients, we administered the depression scale Tsung, the scale of situational anxiety (SA) and personal anxiety (PA) Spielberger-Hanin; QOL was assessed the SF-36 quality of life assessment scale. Correlation analysis using Spearman's rank correlation coefficient. Results The prevalence symptoms mild depression situational or neurotic genesis was 21.1% (12 patients) in Group 1 and 12.0% (6 patients) in Group 2 (p>0.05). Subdepressive state was two percents of patients in Group 1 and Group 2. The incidence SA was 59.6% (31 patients) in Group 1 and 52.0% (26 patients) in Group 2. The incidence PA was 74.0% (37 patients) in Group 2 and 67.3% (35 patients) in Group 1. The average score the physical component of health (PCH) was 29,8±4,3 in Group 1, the mental component of health (MCH) – 49.5±7.4 points; p<0.05. In Group 2: PCH – 44.8±6.6 points, MCH – 26.6±7.5 points; p<0.05. Correlation analysis showed negative strong correlations between SA and MCH (r=−0.64, p=0.0005) and between PA and MCH (r=−0.69, p<0.0001), between SA and PCH (r=−0.71, p=0.0001), between depression and PCH (r=−0.69, p=0.023). Negative statistically significant correlation between depression and MCH (r=−0.69, p=0.54) and negative medium correlation between depression and PCH (r=−0.64, p=0.23). Conclusion These findings suggest that we did not identify patients with symptoms of a true depressive (that can cause pseudodementia and influenced to complete tests). 16.5% patients with AF had mild depression of situational or neurotic genesis. Depression may be a pathogenetic factor of AF or develop because of paroxysms AF – psychological stress. More than 50% patients in Group 1 and Group 2 had an increased anxiety score. SA is more common in patients with permanent AF, probably because older people difficult to adapt to a new situation. PA is more common in patient with paroxysmal AF, probably because disease is sudden and causes anxiety. The PCH of QOL is more impairment in patients with permanent AF, because complications (for example heart failure) impairment physical activity. However, PCH also reduced in patient with paroxysmal AF, because disease is sudden may occur during physical activity. The MCH of QOL is more impairment in patients with paroxysmal AF, because waiting attack effect on mental health and social functioning. An increased level of anxiety and depression negatively affected the mental and physical health of patients with AF. Funding Acknowledgement Type of funding source: None

Sign in / Sign up

Export Citation Format

Share Document