scholarly journals CHRONIC POSTINFARCTION ANEURYSMS OF THE LEFT VENTRICLE: HISTORY, CLINICAL FEATURES, DIAGNOSTIC METHODS. NEW CLASSIFICATION OF CHRONIC POSTINFARCTION ANEURYSMS OF THE LEFT VENTRICLE IN PATIENTS WITH CORONARY ARTERY DISEASE.

2021 ◽  
Author(s):  
Aleksandr V. Bocharov ◽  
Leonid V. Popov ◽  
Astan K Mittsiev ◽  
Magomet D Lagkuev
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Left Ventricular ◽  
Diagnostic Methods ◽  
New Classification ◽  
Historical Aspects ◽  
Artery Disease ◽  
Optimal Treatment Strategy

the article highlights the historical aspects of the development of the concept of diagnosis and treatment of post-infarct left ventricular aneurysms, the possibilities of the main diagnostic methods, and also offers a new classification of post-infarct left ventricular aneurysms, taking into account the type of blood supply and the nature of the coronary lesion, which allows determining the optimal treatment strategy

scholarly journals Sarcomeric Gene Variants and Their Role with Left Ventricular Dysfunction in Background of Coronary Artery Disease

Biomolecules ◽  
2020 ◽  
Vol 10 (3) ◽  
pp. 442 ◽  
Author(s):  
Surendra Kumar ◽  
Vijay Kumar ◽  
Jong-Joo Kim
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Molecular Mechanisms ◽  
Genetic Diagnosis ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Artery Disease ◽  
Sarcomeric Genes

Cardiovascular diseases are one of the leading causes of death in developing countries, generally originating as coronary artery disease (CAD) or hypertension. In later stages, many CAD patients develop left ventricle dysfunction (LVD). Left ventricular ejection fraction (LVEF) is the most prevalent prognostic factor in CAD patients. LVD is a complex multifactorial condition in which the left ventricle of the heart becomes functionally impaired. Various genetic studies have correlated LVD with dilated cardiomyopathy (DCM). In recent years, enormous progress has been made in identifying the genetic causes of cardiac diseases, which has further led to a greater understanding of molecular mechanisms underlying each disease. This progress has increased the probability of establishing a specific genetic diagnosis, and thus providing new opportunities for practitioners, patients, and families to utilize this genetic information. A large number of mutations in sarcomeric genes have been discovered in cardiomyopathies. In this review, we will explore the role of the sarcomeric genes in LVD in CAD patients, which is a major cause of cardiac failure and results in heart failure.

scholarly journals P1399 Global longitudinal systolic deformation of the left ventricle during stress echocardiography with physical exercise may identify patients with severe coronary artery disease

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
A Stepanova ◽  
M N Alekhin
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Left Ventricle ◽  
Stress Echocardiography ◽  
Left Ventricular ◽  
Gensini Score ◽  
Treadmill Test ◽  
Artery Disease ◽  
Diagnostic Capabilities

Abstract Background Assessment of longitudinal systolic deformation of the left ventricular myocardium during speckle tracking stress echocardiography can potentially be significant in the diagnosis of transient myocardial ischemia. In this regard, determination of the global longitudinal systolic deformation (GLSD) of the left ventricle during stress echocardiography is challenging and its diagnostic capabilities can be assessed by comparing them with the data obtained with invasive methods for diagnosing coronary artery disease (CAD). Aim of the study The aim of this study was to determine the diagnostic capabilities of the left ventricular GLSD obtained during stress echocardiography with exercise on the treadmill in defining the presence and significance of CAD. Methods The study included 80 patients (mean age 68.3 ± 7.8 years; 29 females). All patients underwent stress echocardiography with exercise on the treadmill. At rest and after treadmill-test, all patients were measured for the values of the left ventricular GLSD using the AFI (Automated functional imaging) algorithm. The delta of the left ventricular GLSD values was counted. The delta of the left ventricular GLSD values was counted as the difference of the left ventricular GLSD values at rest and after the exercise. All patients underwent coronary angiography, assessment of the severity of CAD was counted according to the Gensini score. According to the results of coronary angiography, the patients were divided into 3 groups: 21 patients without CAD, 45 patients with moderate CAD (<34 points on the Gensini score) and 14 patients with severe CAD (> 34 points on the Gensini score). Results In the group of patients with severe CAD, the value of the left ventricular GLSD delta at rest and after treadmill-test significantly differed from the groups of patients with moderate CAD and without CAD (-0.56 compared with 2.17; p = 0,009). In the group of patients without CAD, the value of the left ventricular GLSD delta at rest and after treadmill-test did not significantly differ from the group of patients with CAD (0.23 compared to -0.95; p = 0.199). Conclusions The delta of the left ventricular GLSD obtained during stress echocardiography with exercise on the treadmill showed a reliable significance in determining severe CAD, but did not demonstrate a reliable significance in identifying the absence of CAD.

scholarly journals Discussion of a new classification for coronary artery disease

2020 ◽  
Vol 25 (2) ◽  
pp. 111-112
Author(s):  
A. S. Galyavich
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
New Classification ◽  
The Creation ◽  
Artery Disease

The article discusses the creation of a new classification for coronary artery disease. The classification of acute and chronic forms of coronary artery disease is proposed as one of the variants.

Automated classification of patients with coronary artery disease using grayscale features from left ventricle echocardiographic images

2013 ◽  
Vol 112 (3) ◽  
pp. 624-632 ◽  
Author(s):  
U. Rajendra Acharya ◽  
S. Vinitha Sree ◽  
M. Muthu Rama Krishnan ◽  
N. Krishnananda ◽  
Shetty Ranjan ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Left Ventricle ◽  
Automated Classification ◽  
Artery Disease ◽  
Echocardiographic Images

scholarly journals N-Terminal Pro-Brain Natriuretic Peptide and Right Ventricular Diameter Are Related to Aspirin Resistance in Coronary Artery Disease Patients

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 706
Author(s):  
Kamila Marika Cygulska ◽  
Łukasz Figiel ◽  
Dariusz Sławek ◽  
Małgorzata Wraga ◽  
Marek Dąbrowa ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Brain Natriuretic Peptide ◽  
Right Ventricular ◽  
Left Ventricular Mass ◽  
Natriuretic Peptide ◽  
Hemoglobin Concentration ◽  
Left Ventricular ◽  
Ventricular Mass ◽  
Artery Disease

Background and Objectives: Resistance to ASA (ASAres) is a multifactorial phenomenon defined as insufficient reduction of platelet reactivity through incomplete inhibition of thromboxane A2 synthesis. The aim is to reassess the prevalence and predictors of ASAres in a contemporary cohort of coronary artery disease (CAD) patients (pts) on stable therapy with ASA, 75 mg o.d. Materials and Methods: We studied 205 patients with stable CAD treated with daily dose of 75 mg ASA for a minimum of one month. ASAres was defined as ARU (aspirin reaction units) ≥550 using the point-of-care VerifyNow Aspirin test. Results: ASAres was detected in 11.7% of patients. Modest but significant correlations were detected between ARU and concentration of N-terminal pro-brain natriuretic peptide (NT-proBNP) (r = 0.144; p = 0.04), body weight, body mass index, red blood cell distribution width, left ventricular mass, and septal end-systolic thickness, with trends for left ventricular mass index and prothrombin time. In multivariate regression analysis, log(NT-proBNP) was identified as the only independent predictor of ARU—partial r = 0.15, p = 0.03. Median concentrations of NT-proBNP were significantly higher in ASAres patients (median value 311.4 vs. 646.3 pg/mL; p = 0.046) and right ventricular diameter was larger, whereas mean corpuscular hemoglobin concentration was lower as compared to patients with adequate response to ASA. Conclusions: ASAres has significant prevalence in this contemporary CAD cohort and NT-proBNP has been identified as the independent correlate of on-treatment ARU, representing a predictor for ASAres, along with right ventricular enlargement and lower hemoglobin concentration in erythrocytes.

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