scholarly journals Radiation diagnostics of cerebral cavernous malformations

2021 ◽  
Vol 2 (1) ◽  
pp. 39-48
Author(s):  
Elena N. Girya ◽  
Valentin E. Sinitsyn ◽  
Alexey S. Tokarev
Keyword(s):  
Pulse Sequences ◽  
Vascular Pathology ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations ◽  
Imaging Sequence ◽  
Magnetic Resonance Imaging Mri ◽  
The Moment ◽  
Ct And Mri ◽  
Selection Of

Cerebral cavernous malformations are a fairly common vascular pathology at the moment, with the number of detected cases increasing dramatically in recent years. This is because modern neuroimaging methods such as computed tomography (CT) and magnetic resonance imaging (MRI) have been introduced into clinical practice and are widely available. Prior to the advent of CT and MRI technologies, it was extremely difficult to diagnose this pathology, and the diagnosis was usually made intraoperatively or based on autopsy data. Further, the literature review is devoted to the radiological diagnosis of cerebral cavernous malformations (CM). The role of neuroimaging methods in the diagnosis of cavernous malformations, as well as the use of MRI for CM visualization, was analyzed. The advantages of MRI over other neuroimaging methods for this pathology have been demonstrated. Pulse sequences of MRI and signaling characteristics of various foci were characterized, depending on the morphological substrate. The significance of the susceptibility-weighted imaging sequence was also evaluated for the detection of multifocal lesions in cases of familial CM. The study of the main pulse sequences of MRI for visualization of CM will improve the protocol algorithm for the timely diagnosis of this pathology and the selection of therapeutic approach.

scholarly journals Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice

2011 ◽  
Vol 208 (9) ◽  
pp. 1835-1847 ◽  
Author(s):  
Gwénola Boulday ◽  
Noemi Rudini ◽  
Luigi Maddaluno ◽  
Anne Blécon ◽  
Minh Arnould ◽  
...  
Keyword(s):  
Autosomal Dominant ◽  
Vascular Malformations ◽  
Vascular Lesions ◽  
Developmental Timing ◽  
Cerebral Cavernous Malformations ◽  
Loss Of Function ◽  
Cavernous Malformations ◽  
The Central Nervous System ◽  
Dominant Condition

Cerebral cavernous malformations (CCM) are vascular malformations of the central nervous system (CNS) that lead to cerebral hemorrhages. Familial CCM occurs as an autosomal dominant condition caused by loss-of-function mutations in one of the three CCM genes. Constitutive or tissue-specific ablation of any of the Ccm genes in mice previously established the crucial role of Ccm gene expression in endothelial cells for proper angiogenesis. However, embryonic lethality precluded the development of relevant CCM mouse models. Here, we show that endothelial-specific Ccm2 deletion at postnatal day 1 (P1) in mice results in vascular lesions mimicking human CCM lesions. Consistent with CCM1/3 involvement in the same human disease, deletion of Ccm1/3 at P1 in mice results in similar CCM lesions. The lesions are located in the cerebellum and the retina, two organs undergoing intense postnatal angiogenesis. Despite a pan-endothelial Ccm2 deletion, CCM lesions are restricted to the venous bed. Notably, the consequences of Ccm2 loss depend on the developmental timing of Ccm2 ablation. This work provides a highly penetrant and relevant CCM mouse model.

scholarly journals The Role of MR Imaging and MR Angiography in the Evaluation of Patients with Headache

2020 ◽  
Vol 8 (B) ◽  
pp. 815-819
Author(s):  
Tomislav Pavlović ◽  
Sanja Trtica ◽  
Marina Milošević ◽  
Hrvoje Budinčević ◽  
Igor Borić
Keyword(s):  
Magnetic Resonance ◽  
Diagnostic Yield ◽  
Venous Malformation ◽  
Vascular Pathology ◽  
Normal Finding ◽  
Common Complaint ◽  
Neurological Abnormalities ◽  
Magnetic Resonance Imaging Mri ◽  
Acute Headache

BACKGROUND: Headache is one of the most common complaint in medical practice and the most often neurological symptom. AIM: The aim of our study was to estimate the frequency of abnormal magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) findings in patients with non-acute headache without focal neurological abnormalities. MATERIAL AND METHODS: The results of the MRI and MRA were retrospectively analyzed. As major abnormalities, we took into account tumor, stroke, extraaxial collection, Chiari malformations, and vascular pathology (aneurysm and arterial-venous malformation). RESULTS: Two hundred twenty-five patients fulfilled the criteria. Out of 225 patients with median age of 37 (18–85) years, 78% of the patients were female and 22% were male. In total, we found 8.4% of major abnormalities. On MRI head scan without MRA analysis, we found 50.7% of normal finding, 47.1% of minor abnormalities and 2.2% of major abnormalities. On MRA scan, we found we found 52.9% of normal finding, 40.9% of minor abnormalities, and 6.2% of major abnormalities. CONCLUSION: Our study demonstrates a low but important diagnostic yield of MRI and MRA examination for patients with non-acute headache without focal neurological abnormalities.

scholarly journals Blood Flow Suppresses Vascular Anomalies in a Zebrafish Model of Cerebral Cavernous Malformations

2019 ◽  
Vol 125 (10) ◽  
Author(s):  
Claudia Jasmin Rödel ◽  
Cécile Otten ◽  
Stefan Donat ◽  
Marta Lourenço ◽  
Dorothea Fischer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Complete Loss ◽  
Vascular Anomalies ◽  
Vascular Pathology ◽  
Cerebral Cavernous Malformations ◽  
Genetic Approach ◽  
Zebrafish Model ◽  
Physiological Factor ◽  
Cavernous Malformations ◽  
Cardiovascular Anomalies

Rationale: Pathological biomechanical signaling induces vascular anomalies including cerebral cavernous malformations (CCM), which are caused by a clonal loss of CCM1/KRIT1 (Krev interaction trapped protein 1), CCM2/MGC4607, or CCM3/PDCD10. Why patients typically experience lesions only in lowly perfused venous capillaries of the cerebrovasculature is completely unknown. Objective: In contrast, animal models with a complete loss of CCM proteins lack a functional heart and blood flow and exhibit vascular anomalies within major blood vessels as well. This finding raises the possibility that hemodynamics may play a role in the context of this vascular pathology. Methods and Results: Here, we used a genetic approach to restore cardiac function and blood flow in a zebrafish model of CCM1. We find that blood flow prevents cardiovascular anomalies including a hyperplastic expansion within a large Ccm1-deficient vascular bed, the lateral dorsal aorta. Conclusions: This study identifies blood flow as an important physiological factor that is protective in the cause of this devastating vascular pathology.

scholarly journals Remarkable Clinical Improvement Following Microsurgical Resection of Left Lingual Gyrus Cerebral Cavernous Malformation: A Case Report

2020 ◽  
Author(s):  
Samer S. Hoz ◽  
Zahraa F. Al-Sharshahi ◽  
Mustafa M. Altaweel ◽  
Saja A. Albanaa
Keyword(s):  
Occipital Lobe ◽  
Surgical Removal ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations ◽  
Recurrent Hemorrhage ◽  
Lingual Gyrus ◽  
Microsurgical Resection ◽  
Clonic Seizures ◽  
Magnetic Resonance Imaging Mri

Abstract Introduction Cerebral cavernous malformations (CCMs) are collections of dilated and irregular capillaries in the brain. Cerebral cavernous malformations are predominantly supratentorial; occipital CCMs are rare. Surgical removal is indicated for CCMs with recurrent hemorrhage, refractory seizures, and expanding lesions. Case Description We describe a case of a 15-year-old male who presented with repeated tonic-clonic seizures and right homonymous hemianopia of 3-week duration. Magnetic resonance imaging (MRI) showed a mass located on the left medial occipital lobe, specifically in the left lingual gyrus. The T2-weighted and T2-gradient echo images confirmed the diagnosis of a CCM. Total microscopic resection was achieved. There were no surgical complications. The visual deficit improved, and the patient was seizure-free on subsequent follow-up visits. Conclusion Surgical resection of an occipital CCM resulted in a remarkable improvement in terms of seizures and visual field deficits.

scholarly journals Creating the self: the intersubjective nature of experience, self-development, and the phenomenon of play

2021 ◽  
Author(s):  
Jessica A. Blackwell
Keyword(s):  
Crucial Role ◽  
Sense Of Self ◽  
The Self ◽  
Linguistic Communication ◽  
Self Development ◽  
Phenomenological Account ◽  
The Moment ◽  
Selection Of ◽  
Child Learning

The purpose of this project is to present a phenomenological account of the role of play in early self-development. Using the writings of Merleau-Ponty, Sartre, Winnicott, Laing, Beauvoir, and a selection of modern psychologists, this project argues that play is an essential component of childhood self-development. Starting with the claim that all human experience is inherently intersubjective, this project argues that other people play a crucial role in shaping our sense of self and who we become. From the moment we are born, other people play a critical and constant role in shaping our perception of who we are and who we can become. It is argued that play, like linguistic communication, is itself a necessarily intersubjective phenomenon, and that authentic acts of play are essentially a matter of the child learning about the nature of reality and other people, and of striving to make sense of these things while simultaneously working on creating the self.

scholarly journals Creating the self: the intersubjective nature of experience, self-development, and the phenomenon of play

2021 ◽  
Author(s):  
Jessica A. Blackwell
Keyword(s):  
Crucial Role ◽  
Sense Of Self ◽  
The Self ◽  
Linguistic Communication ◽  
Self Development ◽  
Phenomenological Account ◽  
The Moment ◽  
Selection Of ◽  
Child Learning

The purpose of this project is to present a phenomenological account of the role of play in early self-development. Using the writings of Merleau-Ponty, Sartre, Winnicott, Laing, Beauvoir, and a selection of modern psychologists, this project argues that play is an essential component of childhood self-development. Starting with the claim that all human experience is inherently intersubjective, this project argues that other people play a crucial role in shaping our sense of self and who we become. From the moment we are born, other people play a critical and constant role in shaping our perception of who we are and who we can become. It is argued that play, like linguistic communication, is itself a necessarily intersubjective phenomenon, and that authentic acts of play are essentially a matter of the child learning about the nature of reality and other people, and of striving to make sense of these things while simultaneously working on creating the self.

scholarly journals The role of MRI in assessing the effectiveness of cerebral cavernous malformations stereotaxic radiosurgical treatment

2021 ◽  
Vol 2 (2S) ◽  
pp. 34-35
Author(s):  
E. N. Girya ◽  
O. L. Evdokimova ◽  
A. A. Kochakova ◽  
V. A. Rak ◽  
E. N. Rozhnova
Keyword(s):  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations

.

Role of Delta-Notch signaling in cerebral cavernous malformations

2016 ◽  
Vol 39 (4) ◽  
pp. 581-589 ◽  
Author(s):  
Souvik Kar ◽  
Arpita Baisantry ◽  
Arya Nabavi ◽  
Helmut Bertalanffy
Keyword(s):  
Notch Signaling ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations

Role of aspirin and statin therapy in patients with cerebral cavernous malformations

2020 ◽  
Vol 78 ◽  
pp. 246-251
Author(s):  
Santiago Gomez-Paz ◽  
Mohamed M. Salem ◽  
Georgios A. Maragkos ◽  
Luis C. Ascanio ◽  
Alejandro Enriquez-Marulanda ◽  
...  
Keyword(s):  
Statin Therapy ◽  
Cerebral Cavernous Malformations ◽  
Cavernous Malformations

scholarly journals MRI of Lateral Skull Base Lesions

2011 ◽  
Vol 3 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Deepak P Patkar ◽  
Rama Yanamandala ◽  
Mukesh Pardhi ◽  
Sona A Pungavkar ◽  
Vishal Gaikwad ◽  
...  
Keyword(s):  
Skull Base ◽  
Pulse Sequences ◽  
Clinical Problem ◽  
Accurate Information ◽  
Mri Findings ◽  
Lateral Skull Base ◽  
Skull Base Lesions ◽  
Magnetic Resonance Imaging Mri ◽  
Mr Pulse Sequences

ABSTRACT This article reviews the role of magnetic resonance imaging (MRI) in the evaluation of lateral skull base lesions. Due to superior soft tissue resolution and multiplanar capability, MRI provides accurate information and exquisite anatomical detail. Thus, it guides the surgeon in proper preoperative planning regarding the approach of a lesion. MRI is also useful in post-treatment follow-up to assess the therapeutic response and to identify potential complications. We discuss the relevant anatomy, indications of MRI and MR pulse sequences used in the diagnosis of lesions of lateral skull base. Characteristic MRI findings of various lesions which help to arrive at a specific diagnosis as well as pitfalls of MRI which may confound the diagnosis are described. Newer MR pulse sequences enable image-guided surgery, which assist the surgeon intraoperatively, are briefly discussed. In summary, this article emphasizes the role of MRI in providing a specific answer to a clinical problem and its ability to guide the clinician for better management of patients.

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