scholarly journals Treatment of diffuse toxic goiter during pregnancy

2017 ◽  
Vol 66 (3) ◽  
pp. 89-96 ◽  
Author(s):  
Julia S. Lovkova ◽  
Vladimir V. Potin ◽  
Natalya N. Tkachenko ◽  
Elisaveta V. Shelayeva
Keyword(s):  
Thyroid Gland ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord Blood ◽  
Subclinical Hypothyroidism ◽  
Subclinical Hyperthyroidism ◽  
Pregnancy And Childbirth ◽  
High Incidence ◽  
Toxic Goiter ◽  
Preterm Rupture Of Membranes

We have studied an influence of diffuse toxic goiter on the flow and outcome pregnancy. 67 pregnant women with diffuse toxic goiter were examined. The group of comparison consisted of 38 pregnant women without thyroid pathology. The levels of free thyroxin, TSH, autoantibodies to TSH-receptors and autoantibodies to thyreoperoxidasis in the blood of pregnant women and umbilical cord blood and ultrasound of the thyroid gland of newborns were analyze. Pregnancy and childbirth of the women with unresolved thyrotoxicosis were more complicated by the threat of termination of pregnancy, preeclampsia, chronic placental insufficiency, preterm rupture of membranes, fetal hypotrophy and hypoxia. A high incidence of subclinical hypothyroidism (more 50%) in newborns is associated with the transplacental pass thyreostatic drugs. Subclinical hyperthyroidism in 17% of newborns should be associated with the transplacental transition from the mother to the fetus of autoantibodies to TSH-receptors.

scholarly journals The influence of diffuse toxic goiter on the course and outcome of pregnancy

2012 ◽  
Vol 61 (4) ◽  
pp. 67-74
Author(s):  
Yulia Sergeevna Lovkova ◽  
Vladimir Vsevolodovich Potin ◽  
Natalya Nikolaevna Tkachenko ◽  
Elisaveta Valeryevna Shelayeva ◽  
Tachira Timurovna Musaeva
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Autoimmune Thyroiditis ◽  
Subclinical Hypothyroidism ◽  
Subclinical Hyperthyroidism ◽  
Thyroid Status ◽  
Toxic Goiter ◽  
Preterm Rupture Of Membranes

We have studied peculiarities of pregnancy, delivery and neonatal thyroid status in 58 women with diffuse toxic goiter. During pregnancy patients received thyreostatic therapy (imidazole and thiouracil derivates). Examination consisted of assessment of levels of free thyroxin, TSH, autoantibodies to TSH-receptors and autoantibodies to thyroperoxidasis in the blood of pregnant women and in umbilical cord blood. The group of comparison consisted of 58 women without thyroid pathology and 111 women with autoimmune thyroiditis. In women with diffuse toxic goiter preeclampsia, chronic placental insufficiency, preterm rupture of membranes, fetal hypotrophy and hypoxia were observed more frequently. 17 % of newborns of mothers with diffuse toxic goiter had subclinical hyperthyroidism and 54% of newborns — subclinical hypothyroidism, depending of transplacental pass of thyreostatic medications

scholarly journals Functional condition of the thyroid gland of newborns from methers with a diffuse toxic goiter

2019 ◽  
Vol 10 (3) ◽  
pp. 24-31
Author(s):  
N. V. Vorokhobina ◽  
Y. S. Lovkova ◽  
A. V. Kuznetsova ◽  
Yu. V. Kovalyova ◽  
V. L. Baranov
Keyword(s):  
Thyroid Gland ◽  
Blood Serum ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Thyroid Stimulating Hormone ◽  
Control Group ◽  
Toxic Goiter ◽  
Thyroid Hyperplasia ◽  
Neonatal Thyrotoxicosis

Objective: to study the functional state of the thyroid gland in newborns from mothers with diffuse toxic goiter, depending on the level of antibodies to thyroid stimulating hormone receptors (AB-rTSH).Materials and methods: 68 newborns from 67 mothers with diffuse toxic goiter were examined. The control group included 49 newborns from 49 mothers without thyroid pathology. To assess the functional state of the thyroid gland of newborns, we determined the levels of thyroid stimulating hormone, free thyroxine (fT4), and AB-rTSH in cord blood and calculated the TSH/fT4 coefficient, which allows us to differentiate congenital hypothyroidism from neonatal thyrotoxicosis. On the 4-7th day of life, all newborns underwent ultrasound examination (ultrasound) of the thyroid gland.Results: newborns from mothers with diffuse toxic goiter had lower growth-weight indices in comparison with the same indices of the control group and they often showed thyroid hyperplasia. It was shown that the increased content of AB-rTSH in the blood serum of pregnant women with diffuse toxic goiter and in the umbilical cord blood of newborns can contribute to the development of neonatal thyrotoxicosis, detected in 16.2 % of newborns.Conclusions: increased levels of AB-rTSH in the blood serum of mothers with DTG, especially in the second half of pregnancy, and in the umbilical cord blood of newborns affect the formation of thyroid hyperplasia in newborns and contribute to the development of neonatal thyrotoxicosis.

scholarly journals Treatment of Pregnant Women with a Betamimetic and Verapamil Increases the Micronuclei Frequency in Umbilical Cord Blood Lymphocytes

2008 ◽  
Vol 215 (4) ◽  
pp. 363-371 ◽  
Author(s):  
Darko Grujicic ◽  
Olivera Miloševic-Djordjevic ◽  
Slobodan Arsenijevic ◽  
Dragoslav Marinkovic
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Lymphocytes ◽  
Cord Blood Lymphocytes

scholarly journals Correlation between maternal and umbilical cord blood in pregnant women of Pokhara Valley: a cross sectional study

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Sameer Timilsina ◽  
Sirisa Karki ◽  
Aajeevan Gautam ◽  
Pujan Bhusal ◽  
Gita Paudel ◽  
...  
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Pokhara Valley

scholarly journals Prevalence of thyroid disorders in pregnancy

2018 ◽  
Vol 7 (9) ◽  
pp. 3493
Author(s):  
Sangeeta Pahwa ◽  
Sabia Mangat
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Antenatal Clinic ◽  
Fetal Outcome ◽  
Overt Hypothyroidism ◽  
Thyroid Disorders ◽  
Subclinical Hyperthyroidism ◽  
Thyroid Screening ◽  
In Pregnancy

Background: Thyroid disorders are among the common endocrine problems in pregnant women. Often overlooked in pregnancy due to nonspecific symptoms and hyper-metabolic state of pregnancy. Western literature shows prevalence of hypothyroidism in pregnancy as 2.5% and hypothyroidism as 0.1-0.4%. There is paucity of data on prevalence of thyroid disorders in India pregnant population. This study was carried out to know prevalence of thyroid disorders in pregnant women in Indian population.Methods: One hundred pregnant women attending antenatal clinic in first trimester were registered. Detailed history and examination was done. Apart from routine basic and obstetrical investigations, TSH, FT3 and FT4 level estimation was done.Results: Prevalence of thyroid dysfunction was high in this study in first trimester pregnant women, with subclinical hypothyroidism in 6%, overt hypothyroidism in 2%, subclinical hyperthyroidism 2 % and overt hyperthyroidism 0%.Conclusions: Prevalence of thyroid disorders, especially subclinical hypothyroidism (6%), overt hypothyroidism (2%) and subclinical hyperthyroidism (2%) was high. To prevent adverse effects on maternal and fetal outcome, we are emphasizing the importance of routine antenatal thyroid screening.

P68 Proportion of iNKT cells in pregnant women with preeclampsia: an evaluation in peripheral blood, placenta and umbilical cord blood

2010 ◽  
Vol 1 ◽  
pp. S60
Author(s):  
Leandro DeOliveira ◽  
Marcos Cenedeze ◽  
Rafael Larocca ◽  
Nelson Sass ◽  
Niels Olsen Câmara
Keyword(s):  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Peripheral Blood ◽  
Inkt Cells

scholarly journals Cytogenetic analysis of 3387 umbilical cord blood in pregnant women at high risk for chromosomal abnormalities

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Yanmei Sun ◽  
Pingping Zhang ◽  
Ning Zhang ◽  
Limin Rong ◽  
Xiaoping Yu ◽  
...  
Keyword(s):  
High Risk ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Cytogenetic Analysis ◽  
Chromosomal Abnormalities

Measurement of CEA, TPA, Neopterin, CA125, CA153 and CA199 in Sera of Pregnant Women, Umbilical Cord Blood and Amniotic Fluid

1989 ◽  
Vol 27 (3) ◽  
pp. 137-142 ◽  
Author(s):  
Ralph J. Lellé ◽  
Eberhard Henkel ◽  
Dieter Leinemann ◽  
Klaus Goeschen
Keyword(s):  
Amniotic Fluid ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

Birth Weight of Mercury Concentrations of Maternal and Umbilical Cord Blood in Pregnant Women

2008 ◽  
Vol 34 (1) ◽  
pp. 12-19
Author(s):  
Byung-Mi Kim ◽  
Dae-Seon Kim ◽  
Jong-Hwa Lee ◽  
Hye-Sook Park ◽  
Young-Ju Kim ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Pregnant Women ◽  
Umbilical Cord ◽  
Umbilical Cord Blood
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