On the pathology of gastric secretion of the peasant population

1930 ◽  
Vol 26 (12) ◽  
pp. 1190-1194
Author(s):  
V. E. Rodionov
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Motor Function ◽  
Laboratory Data ◽  
The State ◽  
Objective Data ◽  
Gastric Diseases ◽  
Gastric Glands ◽  
Chemical Studies ◽  
Physiological Structure

As you know, the majority of gastric suffering is based on the pathology of the secretory and motor function of the stomach, depending or without it on the organic changes in its anatomical and physiological structure. In the presence of a complex of anamnestic and objective data, the state of secretion in each given case is laid on the basis for the diagnosis of gastric diseases, why the laboratory data in connection with the clinic serve as the starting material in our article. We took the result of chemical studies of gastric juice carried out in the Ardatov laboratory for 10 years from 1919 to 1928 inclusive in the amount of 2277 cases. We believe that this material is sufficient to reveal some aspects of the pathology of the function of the gastric glands depending on the conditions of nutrition and life of the peasant population, especially since in relation to nutrition during this period of time the population was in very different conditions.

Cephalic Phase of Gastric Secretion in the Rat

1957 ◽  
Vol 192 (1) ◽  
pp. 23-26 ◽  
Author(s):  
T. M. Lin ◽  
R. S. Alphin
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Free Acid ◽  
Acid Output ◽  
Esophageal Fistula ◽  
Depressing Effect ◽  
Gastric Glands ◽  
Sham Feeding ◽  
Cephalic Phase ◽  
Bilateral Vagotomy

Nineteen sham-feeding tests were performed on eleven rats with a chronic gastric and esophageal fistula. As compared with man and the dog, a slight increase in acid output occurred in 17 tests, the increase being quite definite in 13 tests. Sham feeding had no effect on gastric secretion in 16 tests on rats when performed from 1 to 14 days after bilateral vagotomy. The vagotomy had a profound depressing effect on the interdigestive secretion, no free acid being found in the fasting secretion in any of the rats during the period of these tests. The vagi exert a marked secretory tone on the gastric glands, but the conditioned secretion of gastric juice is probably not of much physiological significance in the rats studied in these tests.

scholarly journals On the chemical mechanism of gastric secretion

1905 ◽  
Vol 76 (510) ◽  
pp. 376-376 ◽  
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Mucous Membrane ◽  
Mechanical Stimulation ◽  
Functional Activity ◽  
Chemical Mechanism ◽  
Secretory Cells ◽  
Gastric Glands ◽  
Chemical Stimuli ◽  
Stimulation Of

It has long been known that the introduction of certain substances into the stomach provoke a secretion of gastric juice. This is regarded as in no sense depending upon mere mechanical stimulation of the mucous membrane, and it has been thought that the nervous mechanism of the gastric glands may be susceptible to certain local chemical stimuli. On the analogy of what has been held to be the mechanism at work in the secretion of pancreatic juice by Bayliss and Starling, it is probable that, in the process of absorption of digested food in the stomach, a substance may be separated from the cells of the mucous membrane which, passing into the blood or lymph, later stimulates the secretory cells of the stomach to functional activity. The following observations support this view:—

Helicobacter pyloricytotoxin VacA increases alkaline secretion in gastric epithelial cells

2001 ◽  
Vol 281 (6) ◽  
pp. G1440-G1448 ◽  
Author(s):  
Lucantonio Debellis ◽  
Emanuele Papini ◽  
Rosa Caroppo ◽  
Cesare Montecucco ◽  
Silvana Curci
Keyword(s):  
Apical Membrane ◽  
Acid Output ◽  
Human Infection ◽  
Gastric Epithelium ◽  
Secondary Development ◽  
Acute Effects ◽  
Gastric Diseases ◽  
Gastric Glands ◽  
Frog Stomach ◽  
Alkaline Secretion

Human infection by the bacterium Helicobacter pylori (Hp) may lead to severe gastric diseases by an ill-understood process involving several virulence factors. Among these, the cytotoxin VacA is associated with higher tissue damage. In this study, the isolated frog stomach model was used to characterize the acute effects of VacA on the gastric epithelium. Our results show that VacA partially inhibits gastric acid output by increasing HCO[Formula: see text] efflux. Experiments conducted with double-barrelled pH or Cl−-selective microelectrodes on surface epithelial gastric cells (SECs) and single gastric glands show that VacA does not impair the activity of the oxyntic cells but renders the apical membrane of SECs more permeable to HCO[Formula: see text] and Cl−. Inhibition of this permeation by 5-nitro-2-(3-phenylpropylamino) benzoic acid indicates that this may be due to the formation of anion-selective pores by the toxin. We suggest that VacA-dependent HCO[Formula: see text] efflux from SECs improves the environmental conditions (pH, CO2concentration) of the niche parasitized by Hp, that is the gastric surface. This may favor Hp persistence in the tissue and the secondary development of a chronic inflammation.

scholarly journals Candida bloodstream infection: data from a teaching hospital in Mato Grosso do Sul, Brazil

2008 ◽  
Vol 50 (5) ◽  
pp. 265-268 ◽  
Author(s):  
Marilene Rodrigues Chang ◽  
Flávia Patussi Correia ◽  
Leonora Correa Costa ◽  
Paula Cristhina Niz Xavier ◽  
Durval Batista Palhares ◽  
...  
Keyword(s):  
Bloodstream Infection ◽  
Teaching Hospital ◽  
Tertiary Care ◽  
Laboratory Data ◽  
The State ◽  
Mato Grosso ◽  
Patients Âgés ◽  
Hospitalization Period ◽  
Candida Bloodstream Infection ◽  
Mato Grosso Do Sul

The incidence of Candida bloodstream infection has increased over the past years. In the Center-West region of Brazil, data on candidemia are scarce. This paper reports a retrospective analysis of 96 cases of Candida bloodstream infection at a Brazilian tertiary-care teaching hospital in the state of Mato Grosso do Sul, from January 1998 to December 2006. Demographic, clinical and laboratory data were collected from medical records and from the hospital's laboratory database. Patients' ages ranged from three days to 92 years, with 53 (55.2%) adults and 43 (44.8%) children. Of the latter, 25 (58.1%) were newborns. The risk conditions most often found were: long period of hospitalization, utilization of venous central catheter, and previous use of antibiotics. Fifty-eight (60.4%) patients died during the hospitalization period and eight (13.7%) of them died 30 days after the diagnosis of candidemia. Candida albicans (45.8%) was the most prevalent species, followed by C. parapsilosis (34.4%), C. tropicalis (14.6%) and C. glabrata (5.2%). This is the first report of Candida bloodstream infection in the state of Mato Grosso do Sul and it highlights the importance of considering the possibility of invasive Candida infection in patients exposed to risk factors, particularly among neonates and the elderly.

Clinical, Radiological and Laboratory Profile of Covid-19 Patients Admitted to a Dedicated Covid-19 Hospital in Odisha

2021 ◽  
Vol 8 (15) ◽  
pp. 989-993
Author(s):  
Mohan Rao C ◽  
Nipa Singh ◽  
Kinshuk Sarbhai ◽  
Saswat Subhankar ◽  
Sanghamitra Pati ◽  
...  
Keyword(s):  
Laboratory Data ◽  
Ct Images ◽  
The State ◽  
Viral Clearance ◽  
Clinical Profile ◽  
Chronic Obstructive ◽  
Laboratory Findings ◽  
Obstructive Pulmonary Disease ◽  
Reactive Protein ◽  
Set Up

BACKGROUND The Covid-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a public health challenge being faced by the world currently. International and national responses to combat the Covid-19 pandemic have been very prompt with the setting up of dedicated Covid-19 hospitals. In the state of Odisha, situated in the eastern part of India, Kalinga Institute of Medical Sciences (KIMS), set up the first dedicated Covid hospital of the state. This study intends to chronicle the clinical profile, radiological presentations, laboratory findings, and clinical outcome of patients admitted to the KIMS Covid hospital. METHODS A retrospective analysis of the clinical and laboratory data of patients admitted with Covid-19 diagnosis at the dedicated Covid-19 hospital from 5th April 2020 to 4th June 2020 was done. RESULTS A total number of 272 Covid-19 cases were included in this study. Majority of the patients were males (83.57 %) and most of the patients (79.04 %) were asymptomatic. The mortality rate was 1.9 %. Fever (18.38 %), cough (17.27 %), dyspnoea (16.91 %) and myalgia (14.7 %) were the major symptoms observed. Severity was mild in 78.94 % cases. Delayed viral clearance was seen in 13 % cases. The typical features of novel SARS-CoV-2 infection was seen in 12 - 13 % cases in computed tomography (CT) images of thorax. c-reactive protein (CRP) was raised as a biomarker of inflammation. Of the 5 deaths encountered, 2 had diabetes mellitus, 2 were hypertensive and 1 had chronic obstructive pulmonary disease (COPD). CONCLUSIONS Covid-19 may have a delayed viral clearance beyond two weeks. A discordance between CT images and the clinical condition may also be observed. Diabetes, hypertension, and high blood CRP levels were significantly associated with mortality. KEYWORDS Covid-19, SARS-CoV-2, Clinical Profile, Radiological Findings, Comorbidities, Fatality

scholarly journals When to collect blood specimens: midmorning vs fasting samples

1998 ◽  
Vol 44 (12) ◽  
pp. 2537-2542 ◽  
Author(s):  
Esa Leppänen ◽  
Benoit Dugué
Keyword(s):  
Healthy Volunteers ◽  
Coefficient Of Variation ◽  
Laboratory Data ◽  
Clinical Decisions ◽  
Objective Data ◽  
Critical Difference ◽  
Blood Specimens ◽  
Medical Specialities

Abstract This study was carried out to define the consequences of collecting blood specimens during the forenoon instead of using fasting specimens collected early in the morning. Extensive laboratory data were obtained from specimens collected from fasting participants at 0800, after breakfast at 0930, and again at 1100. The subjects were inpatients in medical and surgical wards (n = 51; 13 women and 38 men; ages, 32–87 years) and subjectively healthy volunteers corresponding to outpatients (n = 51; 31 women and 20 men; ages, 18–63 years). The coefficient of variation (CV, %) of the patient results was compared with the analytical CV. The observed CVs of the subjects’ results far exceeded the analytical CV (%), the average being 3.5-fold and up to 14-fold for some analytes. In individual results the observed change often exceeded the medically derived clinical critical difference. Laboratory data should always be interpreted in the context in which they were obtained. Clinical decisions should be based on objective data (observations) more than on experience and educated guesses. Different medical specialities and different clinical situations may require different kinds of procedures.

Beta-Glucuronidase Activity in Gastric Juice in Various Gastric Diseases

1973 ◽  
Vol 8 (2) ◽  
pp. 139-144
Author(s):  
I. Rahbek ◽  
J. Lintrup ◽  
E. Jensen ◽  
N. Kromann
Keyword(s):  
Gastric Juice ◽  
Gastric Diseases ◽  
Glucuronidase Activity

Inhibition of gastric secretion by thyroid preparations

1959 ◽  
Vol 196 (6) ◽  
pp. 1262-1265 ◽  
Author(s):  
E. S. Nasset ◽  
V. W. Logan ◽  
M. L. Kelley ◽  
Mary Thomas
Keyword(s):  
Gastric Secretion ◽  
Gastric Juice ◽  
Gradual Decline ◽  
Heidenhain Pouch ◽  
Significant Fall ◽  
Lean Beef ◽  
Inhibition Of Gastric Secretion

Four dogs with Thomas gastric pouches and one dog with a Heidenhain pouch were stimulated to secrete gastric juice by feeding 100 gm of lean beef. Feeding whole desiccated thyroid ordinarily caused a significant fall in volume of gastric juice and in the total quantity of HCl secreted. Crystalline thyroxine yielded erratic results and one trial with triiodothyronine produced a significant increase in gastric secretion. Thyroidectomy in one dog resulted in a gradual decline in secretion, but hypothyroidism produced by administration of mercaptoimidazole in another animal lead to a significant increase in secretion.

Mutagenic and clastogenic activity of gastric juice in human gastric diseases

2002 ◽  
Vol 514 (1-2) ◽  
pp. 125-132 ◽  
Author(s):  
P Hrelia ◽  
C Fimognari ◽  
F Maffei ◽  
G Brandi ◽  
G Biasco ◽  
...  
Keyword(s):  
Gastric Juice ◽  
Gastric Diseases
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