Connective tissue dysplasia in females with primary knee and hip osteoarthritis

Aim. Assessment of the prevalence of connective tissue dysplasia markers in women with primary knee and hip osteoarthritis. Methods. 203 females were examined in a cross-sectional study, with median age 58 years (55-62 years) and duration of post-menopause for 8 years (5.0-12.0 years). Severity of postmenopausal syndrome was defined by modified menopause index scores with the assessment of neurovegetative, metabolic and endocrine and psychoemotional symptoms. Backache and joint pain were assessed by visual analogue scale. Osteoarthritis was diagnosed according to clinical and radiologic criteria. Results. In 153 patients primary osteoarthritis stage 2-3 was diagnosed (group 1), group 2 included 50 patients without osteoarthritis. Screening for connective tissue dysplasia was performed by steps. At first, L.V. Solovyova’s phenotypic screening scale modified by T.F. Peretolchina was used, and cut-off score of 1.92 points was found in 6 (12%) patients without osteoarthritis and 44 (28.8%) in osteoarthritis group, that allowed suggesting connective tissue dysplasia. Then international M.J. Glesby phenotypic scale was used: 53 (34.6%) patients with osteoarthritis and only 1 (2%) subject without osteoarthritis had three and more phenotypic traits (χ2=18.925, р <0.001), that confirms connective tissue dysplasia. On step three, according to Russian guidelines on «Inherited disorders of connective tissue» (Russian scientific society of cardiology, 2012), among examined patients three phenotypes of connective tissue dysplasia were determined: (1) joint hypermobility syndrome; (2) increased dysplastic stigmatization and (3) increased, mostly visceral dysplastic stigmatization. The latter was more prevalent in females with osteoarthritis. Conclusion. High prevalence of connective tissue dysplasia criteria in primary osteoarthritis patients confirms the presence of dysplastic osteoarthritis phenotype and necessity of personalized attitude to patient management.

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Mitral Valve Prolapse In Patients With Benign Joint Hypermobility Syndrome (BJHS)

AL-Kindy College Medical Journal ◽

10.47723/kcmj.v13i1.115 ◽

2019 ◽

Vol 13 (1) ◽

pp. 8-10

Author(s):

Tariq Jassim Mohammed ◽

Tariq Jassim Mohammed

Keyword(s):

Mitral Valve ◽

Mitral Valve Prolapse ◽

Cross Sectional Study ◽

Joint Hypermobility ◽

Control Group ◽

Hypermobility Syndrome ◽

Joint Hypermobility Syndrome ◽

Chi Square ◽

Cross Sectional ◽

Cardiac Assessment

Background: Joint hypermobility was first mentioned by Hippocrates as an isolated feature, when he described the Celts' Incapacity to Pull a Bowstring or Throw a Dart, Due to The Slackness of Their Limbs Objective: to determine the prevalence of mitral valve prolapse(MVP)in patients with benign hypermobility syndrome (BJHS). Type of the study: Cross –sectional study. Methods: Ninety patients with BJHS were included in this study. Full cardiological assessment was done for all of them, which include clinical examination, electrocardiography and echocardiography. Cardiac assessment was done for another sixty age and sex matched (normal mobile) Individuals served as a control group. Statistical analysis was done by using T test or chi square as indicated. Results: Among 90 patients with BJHS, MVP was reported in 26 patients (28.9%) compared to four individuals (6.7%)of the control group on modern echocardiography studies (P=0.013). Conclusions: the prevalence of MVP was significantly higher among patients with BJHS compared to normal mobile individuals.

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Subjective health complaints and illness perception amongst adults with Joint Hypermobility Syndrome/Ehlers–Danlos Syndrome-HypermobilityType – a cross-sectional study

Disability and Rehabilitation ◽

10.1080/09638288.2017.1390695 ◽

2017 ◽

Vol 41 (3) ◽

pp. 333-340 ◽

Cited By ~ 2

Author(s):

Lena Hope ◽

Birgit Juul-Kristensen ◽

Helene Løvaas ◽

Camilla Løvvik ◽

Silje Maeland

Keyword(s):

Illness Perception ◽

Subjective Health ◽

Cross Sectional Study ◽

Joint Hypermobility ◽

Subjective Health Complaints ◽

Hypermobility Syndrome ◽

Joint Hypermobility Syndrome ◽

Cross Sectional ◽

Ehlers Danlos Syndrome ◽

Danlos Syndrome

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Cam morphology is associated with radiographic hip osteoarthritis and hip pain in men but not in women: findings from a cross-sectional study in UK biobank

Osteoarthritis and Cartilage ◽

10.1016/j.joca.2021.02.385 ◽

2021 ◽

Vol 29 ◽

pp. S291-S292

Author(s):

B. Faber ◽

R. Ebsim ◽

F. Saunders ◽

M. Frysz ◽

C. Lindner ◽

...

Keyword(s):

Hip Osteoarthritis ◽

Cross Sectional Study ◽

Hip Pain ◽

Uk Biobank ◽

Sectional Study ◽

Cross Sectional ◽

Cam Morphology

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Clinical Hip Osteoarthritis in Current and Former Professional Footballers and Its Effect on Hip Function and Quality of Life

Journal of Sports Science and Medicine ◽

10.52082/jssm.2021.284 ◽

2021 ◽

pp. 284-290

Author(s):

Dennie van den Noort ◽

Emmeline Oltmans ◽

Haruhito Aoki ◽

Gino M.M.J. Kerkhoffs ◽

Vincent Gouttebarge

Keyword(s):

Quality Of Life ◽

Hip Osteoarthritis ◽

Cross Sectional Study ◽

Football Players ◽

Cross Sectional ◽

Related Quality ◽

Health Related ◽

Hip Function ◽

Professional Footballer

The objective of the study was to establish the prevalence of clinical hip osteoarthritis in current and former professional footballers and to explore its consequences on hip function and health-related quality of life (HRQoL). A cross-sectional study by means of questionnaire was conducted among current and former professional footballers fulfilling the following inclusion criteria: (1) male (2) active or retired professional footballer (3) member of FIFPRO (Football Players Worldwide) (4) between 18 and 50 years old (5) could read and understand texts in French, Spanish, or English. Controls (matched for: gender, age, body weight and height) were also recruited. The main outcome measures were clinical hip osteoarthritis, hip function and HRQoL. Questionnaires were sent to 2,500 members of which 1,401 participated (1,000 current and 401 former professional footballers). Fifty-two controls were recruited. Prevalence of hip osteoarthritis was 2% among current and 8% among former professional footballers. Hip function was significantly (p ≤ 0.001) lower in both types of footballers with hip osteoarthritis than in footballers without hip osteoarthritis and controls. Current and former professional footballers with hip osteoarthritis reported significantly lower physical health scores (p = 0.032, p = 0.002) than those without. Hip osteoarthritis led to a significantly lower score in the physical (p = 0.004) and mental (p = 0.014) component of HRQoL in former footballers compared to the controls, while in current footballers only the physical component was significantly (p = 0.012) lower compared to the controls. Hip osteoarthritis has a higher prevalence in former than in current professional footballers and impacts hip function and HRQoL negatively.

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