Cam morphology is associated with radiographic hip osteoarthritis and hip pain in men but not in women: findings from a cross-sectional study in UK biobank

Abstract Background Hemodialysis (HD) patients suffer from musculoskeletal disorders. The most reported musculoskeletal problem is arthralgia. Hip arthralgia has been commonly reported in patients undergoing HD. Hip pain can lead to a decrease in levels of physical activity, limitation in joint range of motion, and consequently difficulties in performing activities of daily living (ADL) and impair the quality of life (QoL). The aim of the study is to reveal the prevalence of hip pain and related factors in HD patients. This cross-sectional study included 73 patients on prevalent HD whose ages ranged from 25 to 65 years and who were on HD for more than 6 months. Physical examination and radiological imaging were done to every patient. Visual analog scale, Barthel Index, and Short Form-36 were used to evaluate pain, ADL, and QoL, respectively. Results Hip arthralgia was detected in 32 patients. Around 43% of which were diagnosed hip osteoarthritis, 34% greater trochanteric pain syndrome, 15% femoroacetabular impingement, and 6% soft tissue calcifications. Diabetes mellitus and hemodialysis duration were found to be significantly different between the groups of hip pain and without hip pain. Diabetes mellitus was identified as an independent risk factor for hip pain in hemodialysis patients. ADL and QoL were significantly lower in patients with hip pain compared to those without (p < 0.01; p < 0.05, respectively). Conclusions The results of our research show that HD patients should be screened for the presence of hip pain and other musculoskeletal disorders and that this is an area which requires further consideration and medical research.

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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

Bone ◽

10.1016/j.bone.2021.116146 ◽

2021 ◽

pp. 116146

Author(s):

Benjamin G. Faber ◽

Raja Ebsim ◽

Fiona R. Saunders ◽

Monika Frysz ◽

Claudia Lindner ◽

...

Keyword(s):

Cross Sectional Study ◽

Hip Pain ◽

Uk Biobank ◽

Sectional Study ◽

Cross Sectional ◽

Dxa Scans

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Osteophyte size and location on hip DXA scans are associated with hip pain: findings from a cross sectional study in UK Biobank

10.1101/2021.04.26.21255905 ◽

2021 ◽

Author(s):

Benjamin G Faber ◽

Raja Ebsim ◽

Fiona R Saunders ◽

Monika Frysz ◽

Claudia Lindner ◽

...

Keyword(s):

Femoral Head ◽

Joint Space Width ◽

Hip Osteoarthritis ◽

Joint Space ◽

Cross Sectional Study ◽

Hip Pain ◽

Uk Biobank ◽

Cross Sectional ◽

Automated Method ◽

The Relationship

Objective It remains unclear how the different features of radiographic hip osteoarthritis (rHOA) contribute to hip pain. We examined the relationship between rHOA, including its individual components, and hip pain using a novel dual-energy x-ray absorptiometry (DXA)-based method. Methods Hip DXAs were obtained from UK Biobank. An automated method was developed to obtain minimum joint space width (mJSW) from points placed around the femoral head and acetabulum. Osteophyte areas at the lateral acetabulum, superior and inferior femoral head were derived manually. Semi-quantitative measures of osteophytes and joint space narrowing (JSN) were combined to provide a measure of rHOA. Logistic regression was used to examine the relationships between these variables and hip pain, obtained via questionnaires. Results 6,807 hip DXAs were examined. rHOA was present in 353 [5.2%] individuals and was associated with hip pain [OR 2.07 (95% CI 1.54-2.80)] and hospital diagnosed OA [5.73 (2.89-11.36)]. Total osteophyte area and mJSW were associated with hip pain [1.29 (1.21-1.36), 0.84 (0.77-0.92) respectively] in unadjusted models. After mutually adjusting and adding demographic covariates, total osteophyte area continued to have strong evidence of association with hip pain [1.31 (1.23-1.39)] but mJSW did not [0.95 (0.87-1.04)]. Acetabular, superior and inferior femoral osteophyte areas were all independently associated with hip pain [1.19 (1.13-1.26), 1.22 (1.15-1.29), 1.21 (1.14-1.28) respectively]. Conclusion The relationship between DXA-derived rHOA and prevalent hip pain is explained by osteophyte area rather than mJSW. Osteophytes at different locations showed important, potentially independent, associations with hip pain, possibly reflecting the contribution of distinct biomechanical pathways.

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