scholarly journals On the casuistry of progressive paralysis (several cases with acute and prolonged course)

2021 ◽  
Vol XII (2) ◽  
pp. 197-208
Author(s):  
G. A. Dedov

28 / VII. The patient died at 6.30 am. Opening 28 / VII. Great emaciation; stiffness is poorly expressed; on the sacrum and on the right trochanter bedsores. The bones of the cranial vault are thickened, diple is almost absent. Dura mater is spliced ​​in some places with the inner surface of the vault and with the pia mater. The last one is thickened, cloudy (milky stripes), it is removed from the surface of the brain with great difficulty. Brain weight 1397.0; its substance is edematous; the cortical substance is anemic, atrophied; the lateral ventricles are dilated with a large amount of serous fluid. In the internal organs, except for the expansion of the lower lobes of both lungs, no pathological changes were noted.


1889 ◽  
Vol 35 (150) ◽  
pp. 261-271 ◽  

S. Beljahow communicated to the Psychiatric Association of St. Petersburg his observations on four brains of senile dements (“Neurologisches Centralblatt,” No. 3, 1887). Three of these subjects were women. The weights of the brains were 1030, 1035, 1080, and 1100 grammes. Their ages ran from 64 to 75 years. The pathological alterations were similar in all the four cases. There was hardening of the cranial bones; in some cases the diploe had entirely disappeared. The dura mater was found united with the cranium; there was also pachymeningitis hæmorrhagica. The pia mater was thickened, and when detached from the cortex brought away a portion of matter with it. The convolutions were slender; the fissures wider than usual; the cortical portion of the brain diminished in thickness; the vessels of the base of the brain, especially the basilar carotids and the arteries of the Sylvian fissure, were sclerosed and their walls in some places calcified.



2020 ◽  
Vol 18 ◽  
pp. 205873922092685
Author(s):  
Yunna Yang ◽  
Zheng Gu ◽  
Yinglun Song

Subdural osteomas are extremely rare benign neoplasms. Here, we report the case of a 35-year-old female patient with a right frontal and parietal subdural osteoma. The patient presented with a 2-year history of intermittent headache and fatigue. Computerized tomography (CT) scan showed a high-density lesion attached to the inner surface of the right frontal and parietal skull. Magnetic resonance imaging (MRI) demonstrated T1 hyperintensity and T2 hypointensity of the lesion. Intraoperatively, the hard mass was located in subdural space and attached to the dura mater. Histopathological examination revealed lamellated bony trabeculae lined by osteoblasts and the intertrabecular marrow spaces occupied by adipose tissue. The patient underwent neurosurgical resection and recovered without complication. Surgical excision is recommended to extract the symptomatic lesions with overlying dura mater.



BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Eiichiro Amano ◽  
Keisuke Uchida ◽  
Tasuku Ishihara ◽  
Shinichi Otsu ◽  
Akira Machida ◽  
...  

Abstract Background Hypertrophic pachymeningitis (HP) is a rare disorder that involves localized or diffuse thickening of the dura mater. HP is associated with various inflammatory, infectious, and malignant diseases, such as rheumatic arthritis, sarcoidosis, anti-neutrophil cytoplasmic antibody-associated vasculitis, IgG4-related disorders, syphilis, tuberculosis, bacterial and fungal infections, cancer, and idiopathic diseases, when evaluation fails to reveal a cause. Among them, chronic infection with Propionibacterium acnes is a rare etiology of HP, and its pathology remains unclear. Case presentation An 80-year-old man having refractory otitis media with effusion of the right ear presented with progressive right-sided headache and nausea. Post-contrast brain magnetic resonance imaging revealed right mastoiditis and remarkable thickening of the dura mater and enhancement of pia mater extending from the right middle cranial fossa to the temporal lobe. HP secondary to middle ear infection was suspected, and a biopsy of the right mastoid was performed. An anaerobic culture of the biopsied right mastoid showed the growth of P. acnes, and histopathological examination using P. acnes-specific monoclonal antibody (PAB antibody) revealed the infiltration of inflammatory cells with P. acnes. Moreover, using PAB antibody, P. acnes was detected in the biopsy specimen of the thickening dura mater. No granulomas were identified in either specimen. HP was resolved with long-term administration of antibiotics and steroids. Conclusion This is the first documentation of pathologically demonstrated chronic HP associated with P. acnes infection followed by refractory otitis media. This report showed that chronic latent P. acnes infection induces chronic inflammation.



1876 ◽  
Vol 22 (97) ◽  
pp. 99-102
Author(s):  
Fred. W. A. Skae

J. T., a cabinet-maker, was brought to the Asylum from Stirling by two policemen, on the 29th July, about 7 p.m. A certificate of emergency had alone been granted, and there was no further information regarding his case in the form of admission. He was about 30 years of age. He looked in bad health, exhausted, and miserable, and his head was bound up with a handkerchief. He asked the attendant to be careful in removing this, as there was a frightful gash underneath it. When it was undone, however, there was no wound to be seen. There was a large black mark over the right side of his face and ear, which looked as if produced by gunpowder, mixed with a little blood. There was a drop of serous fluid in the ear. The patient answered questions intelligently, though in a languid, dejected manner. He put out his tongue freely when asked. It was foul. Pulse was about 80. The policemen stated that they had been informed he had attempted to shoot himself with a double-barrelled pistol, and that the police-surgeon who had seen him thought the pistol could only have been charged with powder. The patient denied this, however, and said that the pistol had been loaded with bullets. The policemen further stated that after apparently firing both barrels of the pistol at his head early on the morning of the 28th, he had attempted to drown himself in the river Forth. As there was no external wound, nor any symptoms of injury to the brain, and as it was about 40 hours since he had attempted to shoot himself, I concluded that he had missed his aim, and caused nothing more serious than a gunpowder mark on his face. He walked along with an attendant to one of the wards. He there conversed a little with the attendants, as he had been doing in the waiting-room before I saw him, and told them a little about his history. He mentioned that he was married; that he and his wife did not agree; that he had been living away from her for some time; and that he had been drinking pretty freely. He complained of thirst, and said he had a headache. He drank a good deal of water. I saw him again in about half-an-hour, and talked with him a little about himself. He looked ill and wretched, and complained of a tremendous headache. At eight o'clock he walked up stairs with the other patients, undressed himself, and went to bed in a dormitory. After going to bed he became very restless, kicked the clothes about, talked incoherently, and shouted for “John” (apparently his brother). About 10.30 he was removed to a single room. He walked quietly along, and got into his new bed. When visited about an hour afterwards, he was lying in bed, but talking nonsense. At six in the morning the attendant went into his room to waken him. He was lying dead on a mattress on the floor, with his face downwards, his mouth and nose being firmly pressed against the mattress. I saw him almost immediately. He had all the appearance of a person who had died from suffocation, and probably in a convulsion. The face and neck were livid and swollen. The tongue was protruded between the teeth; bloody mucus was on the sheet, and seemed to have come from his mouth and nose. A post-mortem examination was made at the instance of the Procurator Fiscal, by Dr. Moffat, of Falkirk, and myself, at 5 p.m., of which the following is a report:—



2020 ◽  
Vol V (2) ◽  
pp. 140-155
Author(s):  
L. Dydynsky

The study of spinal cord diseases due to its compression until the last day was a controversial issue. The first authors who studied it, namely Olivier and Louis, expressed the opinion that the suffering of the spinal cord in these cases is directly due to the mechanical moment of pressure. This opinion, however, was not held for long in the sciences. In its place, another appeared, which soon acquired the right of citizenship. Michaud, who worked under the leadership of Charcot, created an "inflammatory theory" according to which the changes found in the compressed spinal cord are nothing more than changes in the inflammatory nature, the source of these changes to inflammatory vertebral diseases is the substance of the brain.



The article analyzes metaphor through the prism of neurophysiological approach and theory of artificial intelligence. Also the most important concepts for management of technical object are considered: condition, algorithm and adaptation. Metaphor is an integral element of creative process, its necessary tool, it is metaphorical element in thinking, among others that promotes interaction of logical thinking with insight. Perception of an object means gaining "access" to those programs which control interaction with the object, i.e. through perception that is irrational, relative and limited in humans (and also limited in the robot), is a transition to the rational side of the brain where logical decisions are made. Metaphor and analogy, the abstract operate in the right hemisphere, which is the "producer" of creativity. Thus metaphor is extremely close to creativity and is one of the mechanisms of creative self-realization. Human brain evolved from the brain of animal that interacted with the environment without the help of language and which also has hemispheres of brain. If we consider language as one of the elements of brain improvement, it jeopardizes the approach of many psychologists who believe that language is primary. Animal does not use metaphor when it "communicates" with other animals: it gives signals and signs in its "direct" meaning, while man reinterprets some words through other ones where the spiritual is intertwined with the material. The vestibular apparatus, located in the temporal bone, controls the position of body in space and accelerates its movements, that is why language is spatially oriented, and hence metaphor is. Interestingly, the receptors are also present in the internal organs, such as those that control blood circulation or digestion. Existence of such receptors can explain existence of “occasional” metaphors based not on five known feelings.



2021 ◽  
Vol 118 (3) ◽  
pp. e2002574118
Author(s):  
Éva Mezey ◽  
Ildikó Szalayova ◽  
Christopher T. Hogden ◽  
Alexandra Brady ◽  
Ágnes Dósa ◽  
...  

Almost 150 papers about brain lymphatics have been published in the last 150 years. Recently, the information in these papers has been synthesized into a picture of central nervous system (CNS) “glymphatics,” but the fine structure of lymphatic elements in the human brain based on imaging specific markers of lymphatic endothelium has not been described. We used LYVE1 and PDPN antibodies to visualize lymphatic marker-positive cells (LMPCs) in postmortem human brain samples, meninges, cavernous sinus (cavum trigeminale), and cranial nerves and bolstered our findings with a VEGFR3 antibody. LMPCs were present in the perivascular space, the walls of small and large arteries and veins, the media of large vessels along smooth muscle cell membranes, and the vascular adventitia. Lymphatic marker staining was detected in the pia mater, in the arachnoid, in venous sinuses, and among the layers of the dura mater. There were many LMPCs in the perineurium and endoneurium of cranial nerves. Soluble waste may move from the brain parenchyma via perivascular and paravascular routes to the closest subarachnoid space and then travel along the dura mater and/or cranial nerves. Particulate waste products travel along the laminae of the dura mater toward the jugular fossa, lamina cribrosa, and perineurium of the cranial nerves to enter the cervical lymphatics. CD3-positive T cells appear to be in close proximity to LMPCs in perivascular/perineural spaces throughout the brain. Both immunostaining and qPCR confirmed the presence of adhesion molecules in the CNS known to be involved in T cell migration.



1994 ◽  
Vol 80 (5) ◽  
pp. 928-930 ◽  
Author(s):  
Alok Ranjan ◽  
Geeta Chacko ◽  
Thomas Joseph ◽  
Sushil M. Chandi

✓ A 52-year-old man presented with symptoms of progressive cervical radiculomyelopathy. A myelogram showed an intradural block at the C-6 level. Magnetic resonance T1-weighted imaging revealed a hypointense, sausage-shaped mass extending from C-3 to C-6, located posterolaterally on the right side and pushing the spinal cord to the left and anteriorly. At surgery, a mass was found attached solely to the pia mater, with a normal arachnoid and dura mater overlying it. The mass was excised completely and microscopic examination identified a mesenchymal chondrosarcoma. The patient was symptom-free 6 months after surgery.



Author(s):  
Siavash Hashemi ◽  
Parisa Saboori ◽  
Shahab Mansoor-Baghaei ◽  
Ali M. Sadegh

The human brain trabeculae contain strands of collagen tissues connecting the arachnoid to the pia mater. In this paper the mechanotransductions of the external loads to the head passing through different trabecular architectures of the subarachnoid space were investigated. This has been accomplished by creating several local 2-D models consist of skull, dura mater, arachnoid, trabecular architecture and the brain. Different orientations of several architectures of the trabeculae were also analyzed. All models were subjected to the same loading and constraints. The strains in the brain for each model of the architecture and morphology were determined and compared to other corresponding models. It is concluded that the strain in the brain is less where the tree-shape trabeculae are upright, where the branches are attached to the arachnoid mater and the stems are attached to the pia mater. In addition, in the case of other morphologies the strain in the brain is less when the ratio of the trabecular area to the CSF space is less.



1892 ◽  
Vol 38 (162) ◽  
pp. 397-399
Author(s):  
Edwin Goodall

The following facts appear noteworthy as bearing upon the morbid condition going by the names “hæmatoma of the dura mater” and “pachymeningitis hæmorrhagica interna.” In the course of recent experiments I have had occasion to incise the dura mater of (anæsthetized) rabbits and apply Sp. Vin. Gallic. or diluted cantharidin to the cerebral cortex through the aperture so made. On killing one of the animals after the lapse of 48 hours and opening the skull almost the whole of the right hemisphere (that operated upon) was seen to be covered with dark-red clot. This term is justified by the appearance of the exudate, whatever its origin may have been. On incising and reflecting the dura mater it was found that the clot lined the inner surface of that membrane, and had no connection with the subjacent structures. The vessels of the dura were unduly prominent and numerous, but there was no swelling of the membrane, and, apart from the clot, its inner surface was free from exudate. The clot was raised without difficulty, and washed gently in water; the colouring matter came gradually out, and left a delicate, greyish-pink, translucent, continuous pseudo-membrane of sufficient consistence to permit of manipulation. This was divided into two portions, which were stained with hæmatoxylin and safranin respectively. Microscopically the pseudo-membrane was found to consist of red and white corpuscles (the former in considerable majority), a meshwork of fibres (fibrin, apparently), and an amorphous substance, uniformly stained.



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