scholarly journals Comparative evaluation of the results of surgical treatment of open-angle glaucoma using an Ex-Press® P-200 filtration device and drainage device “anti-glaucoma implant A3”

2021 ◽  
Vol 13 (3) ◽  
pp. 29-36
Author(s):  
Maria K. Grineva ◽  
Sergey Yu. Astakhov ◽  
Vadim A. Turgel
Keyword(s):  
Optical Coherence Tomography ◽  
Surgical Treatment ◽  
Comparative Evaluation ◽  
Open Angle Glaucoma ◽  
Sequential Sampling ◽  
Open Angle ◽  
Drainage Device ◽  
Static Threshold ◽  
Filtration Device

Purpose. The article presents the results of a comparative analysis of the effectiveness of surgical treatment of open-angle glaucoma using the Ex-Press P-200 filtering device and the Anti-glaucoma A3 implant. Materials and methods. Using simple sequential sampling, 52 patients (59 eyes) were divided into 2 groups. The first group was implanted with Ex-Press P-200, the second with Anti-glaucoma implant A3. The follow-up period for patients ranged from 6 months to three years. At each visit, a standard ophthalmic examination was performed. For tonometry, the ICare TA01i portable non-contact tonometer was used. To assess the stabilization of the glaucoma process, we performed static (threshold) automatic perimetry using the Pericom perimeter and optical coherence tomography (OCT) of the optic nerve heads using a Spectralis HRA-OCT tomograph (Heidelberg Engineering). Conclusions. The implantation of devices of both types led to a persistent decrease in intraocular pressure, maintenance of visual functions, and stabilization of the glaucoma process. Intra- and postoperative complications corresponded to the nature of filtering procedures and did not have significant differences in the groups. However, cases of shunt erosion were noted only in the group with implanted Ex-Press devices.

scholarly journals Comparison of the Clinical Efficacy of Draining Autovalve Limbosclerectomy and Trabeculectomy in the Treatment of Primary Open-Angle Glaucoma with Long-Term Follow-Up

2020 ◽  
Vol 17 (1) ◽  
pp. 49-55
Author(s):  
D. V. Lapochkin ◽  
V. I. Lapochkin ◽  
A. V. Lapochkin
Keyword(s):  
Surgical Treatment ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Stage Iv ◽  
Stage I ◽  
Control Group ◽  
Open Angle ◽  
Disposable Instruments

Purpose: to evaluate the immediate and long-term hypotensive efficacy, the number of complications, and the clinical benefits of a draining autovalve limbosclerectomy (DALS) performed using a kit of disposable instruments in patients with POAG of various stages in comparison with trabeculectomy (TE).Patients and Methods. The study is based on the analysis of the clinical and functional condition of 127 eyes of 127 patients with primary open-angle glaucoma (stage I POAG was detected in 2 eyes, stage II in 30 eyes, stage III in 88 eyes and stage IV in 7 eyes). Patients were divided into groups: the main group—76 people who underwent DALS using a set of disposable instruments, and the control group—51 people who underwent TE. The average age of patients is 68.9 ± 10.3 years. Before and within 24 months after surgery, all patients underwent standard diagnostic examinations. The initial level of IOP against the background of the maximum antihypertensive mode varied from 24 to 50 mm. Hg. According to gonioscopy, the angle of the anterior chamber was open in all cases (III–IV degree). Patient exclusion criteria: history of laser or surgical treatment of glaucoma, cataract treatment.Results. After 24 months of follow-up after DALS, the level of IOP in patients with stage I–II of POAG was 14.19 ± 1.83 mm Hg and with III–IV stage of POAG 14.95 ± 2.15 mm Hg, compensation was achieved in 88.2 % of patients without the use of antihypertensive drops. After TE, compensation was received in 72.6 % of patients, the IOP level was 16.9 ± 2.21 and 17.78 ± 2.31 mm Hg. respectively (p < 0.01). After DALS surgery, a decrease in the number of complications was revealed in comparison with TE: a decrease in сiliochoroidal detachment by 9.1 %, hyphema by 2.5 %, ophthalmic hypertension in the early p/o period by 3.2 %, cystic changes in the filtering bleb by 7.1 %.Conclusion. The standardized DALS operation using a disposable tool kit is a new highly effective and safe method for the surgical treatment of glaucoma. DALS may be the operation of choice in the treatment of POAG of all stages.

scholarly journals Choroidal Congestion after Trabeculectomy

2019 ◽  
Vol 10 (3) ◽  
pp. 384-390
Author(s):  
Maria Marenco ◽  
Luigi Borgia ◽  
Aldo Vagge ◽  
Michele Iester
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Case Report ◽  
Visual Impairment ◽  
Open Angle Glaucoma ◽  
Steroid Treatment ◽  
Open Angle ◽  
Retrospective Case ◽  
The Right

The aim of this study is to report a case of choroidal congestion after trabeculectomy. This is a retrospective case report. An 85-year-old male with advanced open-angle glaucoma underwent trabeculectomy in both eyes and during follow-up he complained of visual impairment in the right eye. Thus, spectral domain optical coherence tomography (OCT) was performed and showed choroidal congestion in one eye 1 month after surgery together with a decrease of visual acuity. Symptoms and exam findings resolved with systemic steroids after a 6-month follow-up. OCT is essential for detecting choroidal congestion. This finding can be a possible complication after trabeculectomy and can benefit from steroid treatment.

Topical Bimatoprost Insert for Primary Open-Angle Glaucoma and Ocular Hypertension Treatment - A Phase II Controlled Study

2021 ◽  
Vol 18 ◽  
Author(s):  
Francine Rubião ◽  
Alan Cezar Faria Araújo ◽  
João Bernardo Sancio ◽  
Bárbara Silva Nogueira ◽  
Juçara Ribeiro Franca ◽  
...  
Keyword(s):  
Ocular Hypertension ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
T Test ◽  
Controlled Study ◽  
Therapeutic Drug ◽  
Eye Drops ◽  
Open Angle ◽  
Drug Concentrations

Background: The most common treatment for primary open-angle glaucoma (POAG) is the daily use of eye drops. Sustained-release drug delivery systems have been developed to improve patient adherence by achieving prolonged therapeutic drug concentrations in ocular target tissues while limiting systemic exposure. The purpose of this study is to compare the efficacy and safety of bimatoprost inserts with bimatoprost eye drops in patients with POAG and ocular hypertension (OH). Methods: We include OH and POAG patients aged between 40 and 75 years-old. Both OH and POAG patients had intraocular pressure (IOP) greater than 21 and ≤30 mmHg at 9:00 am without glaucoma medication and normal biomicroscopy. Five normal patients with IOP≤14 mmHg constitute the control group. A chitosan-based insert of bimatoprost was placed at the upper conjunctival fornix of the right eye. In the left eye, patients used one drop of LumiganTM daily at 10:00 pm. For statistical analysis, we used a two-way analysis of variance (ANOVA), Student t-test, and paired t-test. Results: Sixteen POAG and 13 OH patients with a mean age of 61 years were assessed. In both eyes, IOP reduction was similar during three weeks of follow-up (19.5±2.2 mmHg and 16.9±3.1 mmHg), insert, and eye drop, respectively; P=0.165). The percentage of IOP reduction in the third week was 30% for insert and 35% for eye drops (P=0.165). No intolerance or discomfort with the insert was reported. Among the research participants, 58% preferred the use of the insert while 25% preferred eye drops, and 17% reported no preference. Conclusions: Bimatoprost-loaded inserts showed similar efficacy to daily bimatoprost eye drops during three weeks of follow up, without major side effects. This might suggest a possible change in the daily therapeutic regimen for the treatment of POAG and OH.

scholarly journals Transpalpebral Electrical Stimulation as a Novel Therapeutic Approach to Decrease Intraocular Pressure for Open-Angle Glaucoma: A Pilot Study

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Félix Gil-Carrasco ◽  
Daniel Ochoa-Contreras ◽  
Marco A. Torres ◽  
Jorge Santiago-Amaya ◽  
Fidel W. Pérez-Tovar ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Intraocular Pressure ◽  
Pilot Study ◽  
Open Angle Glaucoma ◽  
Constant Current ◽  
Open Angle ◽  
Naive Group ◽  
Treatment Naïve ◽  
The Mean

Purpose. To determine the effect on intraocular pressure of transpalpebral specific exogenous voltages in a cohort of open-angle glaucoma patients. Methods. This is a prospective, comparative, and experimental pilot study. The electrical stimuli applied consisted of 10 Hz, biphasic, nonrectangular current pulses (100 μA) delivered from an isolated constant current stimulator. At intake, baseline IOP measurements were obtained from each eye. The measurement was repeated before and after microstimulation until the end of the treatment. Results. Seventy-eight eyes of 46 patients diagnosed with POAG were studied: 58 eyes with maximum tolerated medical treatment and 20 eyes without treatment (naïve). The mean baseline IOP on the treated POAG group was 19.25 mmHg ± 4.71. Baseline IOP on the naïve group was 20.38 mmHg ± 3.28. At the four-month follow-up visit, the mean IOP value on the treatment group was 14.41 mmHg ± 2.06 (P<0.0001). The obtained mean IOP measurement on the treatment-naïve group was 15.29 mmHg ± 2.28 (P<0.0001). Conclusions. The hypotensive response obtained using transpalpebral electrical stimulation on POAG patients, both on treatment-naïve patients and on patients receiving maximum tolerable treatment, was statistically significant when comparing basal IOP measurements to those obtained at the four-month follow-up visit.

scholarly journals CO2-lézerrel végzett mélysclerectomiával szerzett tapasztalatok

2017 ◽  
Vol 158 (18) ◽  
pp. 701-705 ◽  
Author(s):  
Zoltán Sohajda ◽  
Ildikó Káldi ◽  
Magdolna Kiss ◽  
Andrea Facskó
Keyword(s):  
Visual Acuity ◽  
Intraocular Pressure ◽  
Surgical Treatment ◽  
Open Angle Glaucoma ◽  
Medication Use ◽  
Open Angle

Abstract: Introduction: CO2 laser- assisted sclerectomy surgery (CLASS) can be used for the surgical treatment of open-angle glaucoma. Aim: To introduce our results with CLASS. Method: We performed 21 CLASS operations using OT-134-IOPtiMate (IOPtima Ltd, Ramat-Gan, Israel). Patients were examined on the 1st day, and in the 1st, 3rd, 6th, 9th and 12th months postoperatively. We evaluated intraocular pressure (IOP), antiglaucomatous medication-use, visual acuity, complications. Results: Mean age was 65.6 yrs. Complete success (no hypotensive medication required to target IOP) was achieved in 61.1% (18 patients) at 6 months, whereas in 50% (10 patients) at 12 months. Qualified success (hypotensive medication required to target IOP) was achieved in 72.2% and in 70%, preoperative mean IOP was 29.2 ± 9.4 Hgmm, which falled to 17.7 ± 4.9 Hgmm and 17.3 ± 4.3 Hgmm, respectively. Antiglaucomatous medication use falled significantly from 2.90 ± 0.83 to 2.05 ± 1.46. Apart from 1 macroperforation, no serious complication occurred. Conclusions: With CLASS it is possible to effectively lower intraocular pressure in open-angle glaucoma. Orv Hetil. 2017; 158(18): 701–705.

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