scholarly journals Efficacy of 0.01% dexamethasone solution in comprehensive therapy of dry eye disease

2016 ◽  
Vol 9 (3) ◽  
pp. 32-44
Author(s):  
Vladimir V. Brzheskiy ◽  
Vladimir Yu. Popov ◽  
Irina V. Kalinina ◽  
Natalia M. Kalinina ◽  
Liudmila V. Chenenova
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Eye Diseases ◽  
Surface Epithelium ◽  
Film Stability ◽  
Comprehensive Therapy ◽  
Dexamethasone Phosphate ◽  
Tear Meniscus ◽  
Ocular Surface Epithelium

Introduction. The officinal dosage of dexamethasone solution (0.1%) has a marked localized antiinflammatory effect. But the widespread use of this dose in the management of dry eye diseases is limited by the risk of damage to the cornea. Therefore, the authors developed a solution containing 0.01% dexamethasone phosphate in combination with 6% polyvinylpyrolidone and 1.5%–5.5% dextrose [3].  Aim. To study the effects of this novel anti-inflammatory solution on corneal inflammatory processes. Materials and methods. This study included a cohort of 25 patients (50 eyes) with corneal–conjunctival xerosis. Lower tear meniscus index, precorneal tear film production, stability and osmolarity, and the degree of staining of the ocular surface epithelium with vital solutions were assessed prior to the treatment and on day 28 of the study. The presence of the cytokines IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17A, IL-1Ra, TNF-α, INF-α, and INF-γ in patients’ tear fluid and blood plasma was quantified using ELISA.  All patients were asked to complete a questionnaire to evaluate subjective signs of xerosis of the ocular surface. Results. Statistically significant increases in tear meniscus index, precorneal tear film stability, and main and total tear production, with a significant decrease in tear film osmolarity were observed by day 28 of the study. In addition, positive changes in objective parameters relating to the ocular surface epithelium were further confirmed by the patients’ evaluations of their quality of life. Furthermore, the degree of staining of the ocular surface epithelium with vital solutions also decreased. Conclusions. The results of the study demonstrate the high level of effectiveness of the developed medication as a treatment for dry eye diseases of various etiologies.

Clinical manifestations of the dry eye syndrome for women in menopause

2014 ◽  
Vol 5 (2) ◽  
pp. 25-29
Author(s):  
Nataliya Nikolayevna Sadovnikova ◽  
Galiya Fettyakhovna Kutusheva
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Clinical Manifestations ◽  
Tear Film ◽  
Dry Eye Syndrome ◽  
Menopausal Syndrome ◽  
Film Stability ◽  
Tear Film Stability ◽  
Functional Features ◽  
Subjective Discomfort

To assess the effect of menopausal syndrome manifestations in the manifestation of «dry eye» examined 63 women . All examined the condition of the ocular surface, tear film stability, severity of subjective discomfort . Revealed that the dry eye syndrome in postmenopausal women occurs predominantly in the mild and moderate forms, with the severity of clinical and functional features of dry eye syndrome significantly correlated with severity of menopausal symptoms .

Expression Patterns of Sialylated Epitope Recognized by KL-6 Monoclonal Antibody in Ocular Surface Epithelium of Normals and Dry Eye Patients

2004 ◽  
Vol 45 (7) ◽  
pp. 2212 ◽  
Author(s):  
Yasuhito Hayashi ◽  
Winston W.-Y. Kao ◽  
Nobuoki Kohno ◽  
Miyuki Nishihara-Hayashi ◽  
Atsushi Shiraishi ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Dry Eye ◽  
Ocular Surface ◽  
Expression Patterns ◽  
Surface Epithelium ◽  
Ocular Surface Epithelium

scholarly journals New Possibilities of Tear Replacement Therapy in Patients with Dry Eye Syndrome of Various Origins

2019 ◽  
Vol 16 (2) ◽  
pp. 244-251
Author(s):  
V. V. Brzheskiy ◽  
S. Yu. Golubev ◽  
I. V. Brzheskaya ◽  
V. Yu. Popov
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Sodium Hyaluronate ◽  
Tear Film ◽  
Severe Form ◽  
Dry Eye Syndrome ◽  
Degenerative Changes ◽  
Ocular Surface Disease Index ◽  
Film Stability ◽  
Days Of Therapy

The artificial tears on the basis hyaluronic acid is primary importance today in dry eye syndrome (DES) treatment. In recent years, they have been supplemented Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) differing concentrations of sodium hyaluronate and viscosity. The study is devoted to assessing the effectiveness of these drugs in the treatment of patients with dry eye syndrome (DES) of various etiology and severities.There were 73 volunteers with DES of various etiology: 21 — Sjogren’s syndrome, 24 — meibomian blepharitis, and 28 — perimenopause in the study. All patients were divided into 2 groups: 36 patients of the first group received instillations into conjunctival cavity of the Optinol® Express Moisture (0.21 %) and 37 patients of the second group — Optinol® Deep moistening (0.4 %).Starting from the first days of therapy, all patients had a decrease in the severity of subjective signs of DES, estimated by the value of the ocular surface disease index (OSDI). At the same time, tendency to stop of the degenerative changes in the epithelium of the ocular surface was established. It is characterized by a decrease in the degree of staining. The increasement of the tear film stability and an index of the tear meniscus was found in all patients. The dynamics of the controlled parameters increased, as the instillation of the drugs took place and by the 30th day of therapy. There were significant differences from the baseline values. At the same time, the Optinol® Express Moisture (0.21 %) was more effective (mainly in terms of subjective discomfort and the severity of degenerative changes in the epithelium of the ocular surface) in patients with mild and extremely severe form of the xerosis process.The drug Optinol® Deep Moisture (0.4 %) was more effective in patients with xerosis of moderate severity and severe by the same parameters. In the course of research, we have not observed any side effects of both drugs. It allows us to recommend the drugs Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) to widespread clinical use in treating patients with DES of various etiology. 

scholarly journals Peripheral Neuropathy and Tear Film Dysfunction in Type 1 Diabetes Mellitus

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Stuti L. Misra ◽  
Dipika V. Patel ◽  
Charles N. J. McGhee ◽  
Monika Pradhan ◽  
Dean Kilfoyle ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Peripheral Neuropathy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Lipid Layer ◽  
Film Stability ◽  
Tear Film Stability

Purpose.To compare tear film metrics in patients with type 1 diabetes mellitus (DM) and healthy controls and investigate the association between peripheral neuropathy and ocular surface quality.Methods.Dry eye symptoms were quantified in 53 patients with type 1 DM and 40 age-matched controls. Ocular examination included tear film lipid layer thickness grading, tear film stability and quantity measurement, and retinal photography. DM individuals additionally underwent a detailed neuropathy assessment.Results.Neither mean age nor dry eye symptom scores differed significantly between the DM and control groups (P=0.12andP=0.33, resp.). Tear lipid thickness (P=0.02), stability (P<0.0001), and quantity (P=0.01) were significantly lower in the DM group. Corneal sensitivity was also reduced in the DM group (P<0.001) and tear film stability was inversely associated with total neuropathy score (r=-0.29,P=0.03).Conclusion.The DM group exhibited significantly reduced tear film stability, secretion, and lipid layer quality relative to the age-matched control group. The negative correlation between tear film parameters and total neuropathy score suggests that ocular surface abnormalities occur in parallel with diabetic peripheral neuropathy.

scholarly journals HUBUNGAN PEMAKAIAN KONTRASEPSI HORMONAL TERHADAP KUANTITAS TEAR FILM

2021 ◽  
pp. 483-492
Author(s):  
Muhammad Syauqie ◽  
Najdah Fakhirah Karami
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Tear Film ◽  
Disease Index ◽  
Ocular Surface Disease ◽  
Ocular Surface Disease Index ◽  
Tear Meniscus

Mata kering adalah penyakit multifaktorial yang ditandai dengan hilangnya homeostasis tear film yang diikuti gejala okular akibat penurunan kuantitas tear film. Pada jaringan mata, hormon seksual berperan dalam mengatur struktur dan fungsi dari kelenjar lakrimal. Penggunaan kontrasepsi hormonal merupakan salah satu terapi sistemik yang dapat dihubungkan dengan penurunan kuantitas tear film. Penelitian ini merupakan penelitian analitik dengan pendekatan observasional pada 40 orang wanita dengan rentang usia 21-44 tahun. Kelompok sampel adalah wanita yang menggunakan kontrasepsi hormonal minimal dalam 1 tahun dan kelompok kontrol adalah kelompok yang tidak menggunakan kontrasepsi hormonal. Hasil penelitian dan analisis data mendapatkan rerata uji Schirmer kelompok sampel dan kontrol adalah (21,3±12,7) dan (23,9±10). Rerata terkecil uji Schirmer adalah pada kontrasepsi jenis injeksi 3 bulan, yaitu (18,2 ± 11,6). Pada tear meniscus terjadi penurunan pada kelompok sampel (40%) dan kontrol (30%). Hasil kuesioner ocular surface disease index (OSDI) kelompok sampel didapatkan dry eye ringan (20%), sedang (20%), dan berat (5%). Sementara itu kelompok kontrol hanya mengalami dry eye ringan (45%). Dalam penelitian ini menunjukkan tidak terdapat perbedaan hasil yang bermakna (p > 0,05) antara kelompok tersebut. Kesimpulan yang didapatkan adalah tidak terdapat hubungan yang bermakna pemakaian kontrasepsi hormonal dengan kuantitas tear film.

scholarly journals Pax6 Downregulation Mediates Abnormal Lineage Commitment of the Ocular Surface Epithelium in Aqueous-Deficient Dry Eye Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e77286 ◽  
Author(s):  
Ying Ting Chen ◽  
Feeling Y. T. Chen ◽  
Trinka Vijmasi ◽  
Denise N. Stephens ◽  
Marianne Gallup ◽  
...  
Keyword(s):  
Dry Eye ◽  
Ocular Surface ◽  
Dry Eye Disease ◽  
Lineage Commitment ◽  
Eye Disease ◽  
Surface Epithelium ◽  
Ocular Surface Epithelium

scholarly journals How Ocular Surface Disorder Affected Corneal Graft Survival

2021 ◽  
Author(s):  
Sharita Siregar
Keyword(s):  
Graft Survival ◽  
Dry Eye ◽  
Ocular Surface ◽  
Defense Mechanism ◽  
Tear Film ◽  
Corneal Graft ◽  
Surface Epithelium ◽  
Immunological Mechanism ◽  
Inflammatory Processes ◽  
Immunological Reactions

The ocular surface is formed by three component tissues: The cornea, conjunctiva, and limbus all play an important role in keeping a good and clear corneal graft. As part of non-immunological reactions, glaucoma and ocular surface disorders can increase the possibility of corneal graft failure. For that reason, maintaining a healthy and moist ocular surface, depends on an intimate relationship between healthy ocular surface epithelia, the tear film, and the eyelid, which will all increase corneal graft survival. A moist conjunctiva composed of lymphatic tissue as our defense mechanism against infection, will keep the cornea avascular, remaining crystal clear, dehydrated, and protected. Ocular surface epithelium cannot survive without tears. To specified, each component tissue that forms the ocular surface is equally important. Several previous studies revealed that dry eye disease as a form of ocular surface disorders (OSD), can lead to graft rejection. To our knowledge, there are two conditions that cause dry eye syndrome. It can be caused by lipid tear deficiency or aqueous tear deficiency. The severity of dry eye also ranges widely with some mild inflammatory processes leading to severe chronic conditions (i.e., cicatrizing conjunctivitis) that are known to be an absolute contraindication for total or full penetrating keratoplasty. The basic immunological mechanism of dry eye, as one of the most forms of ocular surface disorders that altered corneal graft survival will be discussed specifically in this chapter.

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