Prevention and treatment of degenerative changes in ocular surface epithelium in patients with dry eye syndrome

The artificial tears on the basis hyaluronic acid is primary importance today in dry eye syndrome (DES) treatment. In recent years, they have been supplemented Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) differing concentrations of sodium hyaluronate and viscosity. The study is devoted to assessing the effectiveness of these drugs in the treatment of patients with dry eye syndrome (DES) of various etiology and severities.There were 73 volunteers with DES of various etiology: 21 — Sjogren’s syndrome, 24 — meibomian blepharitis, and 28 — perimenopause in the study. All patients were divided into 2 groups: 36 patients of the first group received instillations into conjunctival cavity of the Optinol® Express Moisture (0.21 %) and 37 patients of the second group — Optinol® Deep moistening (0.4 %).Starting from the first days of therapy, all patients had a decrease in the severity of subjective signs of DES, estimated by the value of the ocular surface disease index (OSDI). At the same time, tendency to stop of the degenerative changes in the epithelium of the ocular surface was established. It is characterized by a decrease in the degree of staining. The increasement of the tear film stability and an index of the tear meniscus was found in all patients. The dynamics of the controlled parameters increased, as the instillation of the drugs took place and by the 30th day of therapy. There were significant differences from the baseline values. At the same time, the Optinol® Express Moisture (0.21 %) was more effective (mainly in terms of subjective discomfort and the severity of degenerative changes in the epithelium of the ocular surface) in patients with mild and extremely severe form of the xerosis process.The drug Optinol® Deep Moisture (0.4 %) was more effective in patients with xerosis of moderate severity and severe by the same parameters. In the course of research, we have not observed any side effects of both drugs. It allows us to recommend the drugs Optinol® Express Moisture (0.21 %) and Optinol® Deep Moisture (0.4 %) to widespread clinical use in treating patients with DES of various etiology.

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Efficacy of 0.01% dexamethasone solution in comprehensive therapy of dry eye disease

Ophthalmology journal ◽

10.17816/ov9332-44 ◽

2016 ◽

Vol 9 (3) ◽

pp. 32-44

Author(s):

Vladimir V. Brzheskiy ◽

Vladimir Yu. Popov ◽

Irina V. Kalinina ◽

Natalia M. Kalinina ◽

Liudmila V. Chenenova

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Eye Diseases ◽

Surface Epithelium ◽

Film Stability ◽

Comprehensive Therapy ◽

Dexamethasone Phosphate ◽

Tear Meniscus ◽

Ocular Surface Epithelium

Introduction. The officinal dosage of dexamethasone solution (0.1%) has a marked localized antiinflammatory effect. But the widespread use of this dose in the management of dry eye diseases is limited by the risk of damage to the cornea. Therefore, the authors developed a solution containing 0.01% dexamethasone phosphate in combination with 6% polyvinylpyrolidone and 1.5%–5.5% dextrose [3]. Aim. To study the effects of this novel anti-inflammatory solution on corneal inflammatory processes. Materials and methods. This study included a cohort of 25 patients (50 eyes) with corneal–conjunctival xerosis. Lower tear meniscus index, precorneal tear film production, stability and osmolarity, and the degree of staining of the ocular surface epithelium with vital solutions were assessed prior to the treatment and on day 28 of the study. The presence of the cytokines IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17A, IL-1Ra, TNF-α, INF-α, and INF-γ in patients’ tear fluid and blood plasma was quantified using ELISA. All patients were asked to complete a questionnaire to evaluate subjective signs of xerosis of the ocular surface. Results. Statistically significant increases in tear meniscus index, precorneal tear film stability, and main and total tear production, with a significant decrease in tear film osmolarity were observed by day 28 of the study. In addition, positive changes in objective parameters relating to the ocular surface epithelium were further confirmed by the patients’ evaluations of their quality of life. Furthermore, the degree of staining of the ocular surface epithelium with vital solutions also decreased. Conclusions. The results of the study demonstrate the high level of effectiveness of the developed medication as a treatment for dry eye diseases of various etiologies.

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Pax6 Downregulation Mediates Abnormal Lineage Commitment of the Ocular Surface Epithelium in Aqueous-Deficient Dry Eye Disease

PLoS ONE ◽

10.1371/journal.pone.0077286 ◽

2013 ◽

Vol 8 (10) ◽

pp. e77286 ◽

Cited By ~ 7

Author(s):

Ying Ting Chen ◽

Feeling Y. T. Chen ◽

Trinka Vijmasi ◽

Denise N. Stephens ◽

Marianne Gallup ◽

...

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Dry Eye Disease ◽

Lineage Commitment ◽

Eye Disease ◽

Surface Epithelium ◽

Ocular Surface Epithelium

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Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.10-5334 ◽

2010 ◽

Vol 51 (9) ◽

pp. 4677 ◽

Cited By ~ 12

Author(s):

Imran Mohammed ◽

Hanif Suleman ◽

Ahmad M. Otri ◽

Bina B. Kulkarni ◽

Peng Chen ◽

...

Keyword(s):

Gene Expression ◽

Ocular Surface ◽

Surface Epithelium ◽

Ocular Surface Epithelium

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Dry Eye Syndrome-Related Quality of Life in Glaucoma Patients

European Journal of Ophthalmology ◽

10.1177/112067210901900409 ◽

2009 ◽

Vol 19 (4) ◽

pp. 572-579 ◽

Cited By ~ 78

Author(s):

Gemma Caterina Maria Rossi ◽

Carmine Tinelli ◽

Gian Maria Pasinetti ◽

Giovanni Milano ◽

Paolo Emilio Bianchi

Keyword(s):

Quality Of Life ◽

Dry Eye ◽

Ocular Surface ◽

Cross Sectional Study ◽

Dry Eye Syndrome ◽

Control Group ◽

Ocular Surface Disease Index ◽

Symptom Scale ◽

Cross Sectional

Purpose To verify the presence of dry eye syndrome (DES) in treated patients with glaucoma and to analyze DES's impact on the patients' quality of life (QOL) versus the control group. Methods In this observational cross-sectional study, 61 patients were enrolled at a clinical practice. Patients were divided into three groups by number of glaucoma drops instilled per day (G1=1 drop/day, G2=2 drops/day, G3=3 drops/day). A control group of 20 subjects was also selected (G0). All subjects were submitted to a complete ocular examination (including tear function and ocular surface status) and completed the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ), Glaucoma Symptom Scale (GSS) questionnaire, and Ocular Surface Disease Index (OSDI). DES was defined as presence of punctate keratitis and decreased break-up time. Statistical analysis was performed applying the Kruskal-Wallis analysis of variance and Mann-Whitney U tests (to compare median values between groups) as well as the χ2 and Fisher test (to verify significant differences). Results A total of 40% of G3 and 39% of G2 patients presented DES versus 11% of G1 and 5% of G0 (p=0.01). QOL was significantly influenced and altered (NEI-VFQ 25 total mean and GSS total mean and symptoms average: p=0.0085, p=0.006, and p=0.03, respectively). OSDI pointed out differences by group: 26% of G2 and 15% of G3 presented moderate OSDI and 15% of G3 and 8.7% of G2 severe OSDI (p>0.05). Conclusions Patients with topically treated glaucoma present DES more often than a similar control group (p=0.01). The presence of DES negatively influences the patient's QOL. The patients with glaucoma's ocular surface status should be evaluated regularly to ensure the timely detection and treatment of pathologic signs on the ocular surface.

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The autocrine derivation of the opioid growth factor, [Met5]-enkephalin, in ocular surface epithelium

Brain Research ◽

10.1016/s0006-8993(98)00123-1 ◽

1998 ◽

Vol 792 (1) ◽

pp. 72-78 ◽

Cited By ~ 19

Author(s):

Ian S Zagon ◽

Joseph W Sassani ◽

Yan Wu ◽

Patricia J McLaughlin

Keyword(s):

Growth Factor ◽

Ocular Surface ◽

Surface Epithelium ◽

Opioid Growth Factor ◽

Ocular Surface Epithelium

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Changes the Ocular Surface after Corneal Refractive Surgery. Review

Ophthalmology in Russia ◽

10.18008/1816-5095-2020-3-344-350 ◽

2020 ◽

Vol 17 (3) ◽

pp. 344-350

Author(s):

S. V. Trufanov ◽

E. V. Sukhanova ◽

A. A. Tyurina

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Refractive Surgery ◽

High Efficiency ◽

High Specificity ◽

Functional Results ◽

Dry Eye Syndrome ◽

Specificity And Sensitivity ◽

Surgery Research ◽

Corneal Refractive Surgery

Modern corneal refractive surgery provides high efficiency, safety, predictability and stability of the different ametropia kinds correction’s clinically-functional results. However, in overwhelming percentage of cases, having spent some time after surgery patients complain about discomfort, eyes dryness, burning, feel gritty, redness, blurred and vision instability. Complaints mentioned above are caused by the appearance of transitory dry eye syndrome. Main etiology and pathogenesis factors of this disease are presented in this review. The results of dry eye syndrome classical diagnosis methods have been analyzed, as well as modern techniques, characterized by high specificity and sensitivity, which allow to increase the dry eye’s diagnostics accuracy. The study of the dry syndrome after corneal refractive surgery is devoted to a huge number of works of domestic and foreign authors. However, at present time there is no unique algorithm for assessing the damage of the ocular surface before and after corneal refractive surgery, which would include a set of high-precision and specific techniques for quickly and reliably evaluate the severity of dry eye syndrome, allowing to develop preventive measures and pathogenetically oriented treatment and, thereby, accelerate rehabilitation of patients after surgery. Research continuation is needed in this direction.

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