scholarly journals Clinical variants of chronic gastritis in childhood

2021 ◽  
Vol 38 (6) ◽  
pp. 35-42
Author(s):  
E. M. Spivak ◽  
O. M. Manyakina ◽  
I. S. Akkuratova-Maksimova ◽  
O. V. Shkolina
Keyword(s):  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Human Herpes ◽  
Highly Pathogenic ◽  
Barr Virus ◽  
Morphological Studies ◽  
Clinical Variants ◽  
Epstein Barr ◽  
Human Herpes Viruses

Objective. To establish the features of various clinical variants of chronic gastritis in childhood. Material and methods. 415 children aged 617 years with chronic Hp-associated gastritis were examined. The clinical and anamnestic data, the results of laboratory, endoscopic and morphological studies of gastrobioptates were analyzed. Genetic typing of Hp was carried out with the determination of 16 pathogenicity factors. The persistence of human herpes viruses of types 6 and 8 and Epstein Barr viruses in the gastric mucosa was determined. Results. The clinical heterogeneity of chronic gastritis in children with the allocation of four topical variants was established: isolated duodenitis, duodenogastritis, antrum gastritis, pangastritis. It was found that with the first two, a high frequency of giardiasis is registered, with antrumgastritis and especially pangastritis, a significant contamination of the gastric mucosa with Hp is detected, mainly of CagA and VacA-positive strains. It is proved that the persistence of the type 6 human herpes virus does not affect the severity of inflammation, while the presence of the Epstein-Barr virus increases it. Colonization of the gastric mucosa by highly pathogenic Hp strains significantly increases the severity and activity of inflammation. It is shown that atrophy of the gastric mucosa in children is uncertain, and true atrophic gastritis occurs only in 0.61 % of cases. Conclusions. Chronic gastritis in children is a heterogeneous pathology, and its individual variants differ significantly in etiological factors including infectious, pathogenetic mechanisms and features of the morphology of gastric mucosa. This should be taken into account when carrying out medical support for patients.

scholarly journals Helicobacter pylori and Epstein–Barr Virus Infection in Gastric Diseases: Correlation with IL-10 and IL1RN Polymorphism

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Fasciana Teresa ◽  
Nicola Serra ◽  
Giuseppina Capra ◽  
Chiara Mascarella ◽  
Cesare Gagliardi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Normal Gastric Mucosa ◽  
Gastric Diseases ◽  
Barr Virus ◽  
Genes Encoding ◽  
Epstein Barr

Introduction. Helicobacter pylori and Epstein–Barr virus (EBV) infection have recently been shown to be associated with gastric diseases. Polymorphisms in genes encoding cytokines such as interleukin 10 (IL-10) and interleukin 1 Receptor (IL-1RN) influence cytokine secretion levels and appear to contribute to the risk of developing gastroduodenal diseases. To our knowledge, this is the first preliminary study to address the association of coinfection with H. pylori and EBV and their correlation with genetic predisposition in the development of gastric diseases. Methods. Gastric biopsy samples of 96 patients with different gastric diseases were used. Results. Our results showed that the rate of coinfection was higher in patients with gastric cancer than in patients with normal gastric mucosa, active chronic gastritis, and MALT lymphoma. As regards the characterization of H. pilory strains, the polymorphism s1m1i1 of vacA gene was more frequent in patients with MALT Lymphoma in comparison to others, while the polymorphism s2m2i2 was most frequent in patients with normal gastric mucosa. In addition, patients who tested positive for the cagA gene were more frequently those affected with gastric cancer than those with inactive chronic gastritis. Similarly, the patients with oipA gene ON were more frequently those with gastric cancer than those with inactive chronic gastritis. Conclusion. According to our analysis, there was no correlation between coinfection and polymorphisms in genes encoding IL-10 and IL-1RN. We conclude that various factors can be involved in the development of gastric diseases.

T- and B-cell clonality and frequency of human herpes viruses-6, -8 and Epstein Barr virus in angioimmunoblastic T-cell lymphoma

2004 ◽  
Vol 22 (4) ◽  
pp. 169-177 ◽  
Author(s):  
Maruska Marusic Vrsalovic ◽  
Petra Korac ◽  
Mara Dominis ◽  
Slobodanka Ostojic ◽  
Christine Mannhalter ◽  
...  
Keyword(s):  
B Cell ◽  
Epstein Barr Virus ◽  
Cell Lymphoma ◽  
Herpes Viruses ◽  
Human Herpes ◽  
Angioimmunoblastic T Cell Lymphoma ◽  
Barr Virus ◽  
Epstein Barr ◽  
Cell Clonality ◽  
Human Herpes Viruses

scholarly journals Coinfection of gastric mucosa with Helicobacter Pylori and Epstein-Barr virus as a factor of ineffectiveness of antihelicobacter chronic gastritis therapy in adolescents

2019 ◽  
Vol 36 (1) ◽  
pp. 27-30
Author(s):  
I. S. Akkuratova ◽  
E. M. Spivak ◽  
O. M. Manyakina
Keyword(s):  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Inflammatory Process ◽  
Clinical Symptoms ◽  
Risk Group ◽  
The Body ◽  
Therapy Failure ◽  
Barr Virus ◽  
Epstein Barr

Aim. To assess the character of bacterial-viral infection of the gastric mucosa and dynamics of inflammatory process in adolescents with chronic gastritis in case of antihelicobacter therapy failure. Materials and methods. Seventy two adolescents with chronic gastritis aged 11–18 years (mean age 13.8 ± 0.4) were examined prior to and after antihelicobacter therapy. Results. It was established that after treatment against the background of regression of clinical symptoms, in most patients no positive dynamics of process manifestation or its progression was noted both in the body and antral part of the stomach. Conclusions. In the absolute majority of adolescents with the absence of Hp eradication (78.7 %) there was observed colonization with positive Hp strains and persistence of Epstein-Barr virus (68.1 %). It allows considering patients with such co-infection as a risk group for the absence of Hp eradication.

scholarly journals Peculiar features of inflammatory process in gastric mucosa with different character of its bacterioviral infection in adolescents with chronic gastritis

2018 ◽  
Vol 35 (6) ◽  
pp. 10-15
Author(s):  
E. M. Spivak ◽  
O. M. Manyakina ◽  
I. S. Akkuratova
Keyword(s):  
Gastric Mucosa ◽  
Chronic Gastritis ◽  
Inflammatory Process ◽  
Clinical Manifestations ◽  
Gastric Body ◽  
Morphological Examination ◽  
Barr Virus ◽  
Highly Active ◽  
Epstein Barr ◽  
Active Inflammation

Aim. To characterize the inflammatory process in gastric mucosa among adolescents with chronic gastritis in different variants of its bacterioviral infection. Materials and methods.Clinicoanamnestic, laboratory, endoscopic and morphological examination of 200 adolescents (age range 12–18 years) with chronic gastritis was carried out. In all patients, clinicoanamnestic data, standard laboratory study, esophagogastroduodenoscopy, gastrobiopsy followed by morphological analysis with visual analogue scale were assessed. According to the results of examination, all adolescents were divided into 4 groups depending on the character of bacterioviral infection of gastric mucosa. Results. No statistically significant differences were detected while comparing the rate of clinical manifestations of pain abdominal, dyspeptic, intoxication and asthenovegetative syndromes as well as changes, revealed in laboratory and ultrasound studies in the above mentioned groups of adolescents. Maximal presentation of macroscopic and pathohistological changes was registered in patients of group 4 (association between colonization of GM with highly pathogenic Hp strains and EBV persistence). Conclusions. The character of bacterioviral infection of gastric mucosa significantly determines the manifestation degree and activity of inflammatory process. The least degree of manifestation and activity of inflammatory process is registered when mucosa is colonized by low pathogenic Hp strains. Maximal presentation of macroscopic and pathohistological changes in the gastric mucosa is registered in adolescents with associated infection by high pathogenic Hp strains and Epstein-Barr virus. It is manifested by domination of marked and highly active inflammation and appearance of the signs of mucosal atrophy of gastric body and antrum.

Frequency infections of Helicobacter pylori and Epstein - Barr virus in Iraqi patients with chronic gastritis and their serum level of P16

Gene Reports ◽  
2021 ◽  
Vol 23 ◽  
pp. 101165
Author(s):  
Raed Obaid Saleh ◽  
Najwa Shihab Ahmed ◽  
Emad A. Ewais ◽  
Aqeel Shakir Mahmood ◽  
Ahmed R. Sofy
Keyword(s):  
Helicobacter Pylori ◽  
Serum Level ◽  
Chronic Gastritis ◽  
Epstein Barr Virus ◽  
Barr Virus ◽  
Epstein Barr
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