Aggressive course of a rare type of urethral cancer in women

2020 ◽  
Vol 10 (2) ◽  
pp. 181-186
Author(s):  
Olga S. Streltsova ◽  
Katerina E. Yunusova ◽  
Valentin N. Krupin ◽  
Vasiliy V. Vlasov ◽  
Anton S. Kuyarov
Keyword(s):  
Clear Cell ◽  
Clinical Course ◽  
Malignant Tumors ◽  
Cancer Surveillance ◽  
Clear Cell Adenocarcinoma ◽  
Rare Form ◽  
Rare Type ◽  
Pelvic Organs ◽  
Proximal Urethra ◽  
Urethral Diseases

The article provides a clinical case of urethral cancer in women. Primary urethral carcinomas are rare, less than 1% of all malignant tumors. According to the Rarecare Cancer Surveillance Agency for Europe (RARECARE), urethral cancer in women is 0.6 and 1.6 in men per 1 million people per year. A 56-year-old patient with histologically verified clear cell adenocarcinoma of the proximal urethra was monitored for 18 months. An aggressive course of the tumor process has been shown, which led to the need to perform anterior exenteration of the pelvic organs. The histogenesis of primary clear cell urethral adenocarcinoma has not been definitively determined. The atypical external localization in the described case suggests the periurethral origin of this cancerous tumor from the Skenes glands. The demonstration of a rare form of urethral cancer, clear cell adenocarcinoma, contributes to the accumulation of knowledge about its histopathology and clinical course, as well as increasing cancer alertness in the treatment of urethral diseases in doctors of any specialty.

Complications of Prenatal Therapy With Diethyistilbestrol

PEDIATRICS ◽  
1978 ◽  
Vol 62 (6) ◽  
pp. 1151-1159
Author(s):  
Arthur L. Herbst ◽  
Robert E. Scully ◽  
Stanley J. Robboy ◽  
William R. Welch
Keyword(s):  
Clear Cell ◽  
Epidemiologic Study ◽  
Epidemiological Studies ◽  
Clear Cell Adenocarcinoma ◽  
Rare Type ◽  
Young Females ◽  
Intrauterine Exposure ◽  
Risk Pregnancy ◽  
Fetal Wastage ◽  
Synthetic Estrogens

Cancer of the vagina is a rare type of genital malignancy that usually occurs as squamous cell carcinoma in postmenopausal women. Vaginal clear cell adenocarcinoma (Fig. 1), which used to be termed "mesonephroma," is an extremely rare type of genital cancer and was almost never encountered in younger patients until recently. In 1970, a clinical and pathologic study of seven cases of clear cell adenocarcinoma of the vagina in females between the ages of 14 and 22 years was published; all of them had been seen or treated in the late 1960s. These seven cases exceeded the total number of this type of cancer that had been previously reported in this age group.1 The next year, a retrospective epidemiologic study was conducted that included an additional case, and this cohort of eight was compared to 32 controls. It was found that the risk of development of these carcinomas was significantly associated with intrauterine exposure to diethylstilbestrol.2 Diethylstilbestrol therapy for high-risk pregnancy to reduce fetal wastage had been very popular in the late 1940s and 1950s. However, its use was stated to be contraindicated in 1971 by the Food and Drug Administration after the results of the initial epidemiological studies were confirmed.3 Clear cell adenocarcinoma of the cervix has also been associated with intrauterine exposure to diethylstilbestrol.4,5 In addition, other similar nonsteroidal synthetic estrogens such as dienestrol and hexestrol have also been implicated in the association. Studies of the clinical, epidemiological, and pathologic aspects of these neoplasms have been centralized in the Registry for Research on Hormonal Transplacental Carcinogenesis (formerly the Registry of Clear Cell Adenocarcinoma of the Genital Tract in Young Females).

scholarly journals Clear cell adenocarcinoma presenting as acute pancreatitis: A rare form of primary pancreatic malignancy

2020 ◽  
Vol 3 (5) ◽  
Author(s):  
Robert S. O'Neill ◽  
Lyn L. Lam ◽  
Parthsinh Solanki ◽  
Robyn Levingston ◽  
David Thomas
Keyword(s):  
Acute Pancreatitis ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Rare Form ◽  
Pancreatic Malignancy

Rare localization of renal cell carcinoma metastases in the paranasal sinuses and breast: a case report

2019 ◽  
Vol 22 (6) ◽  
pp. 13-22
Author(s):  
E. V. Kryaneva ◽  
N. A. Rubtsova ◽  
A. V. Levshakova ◽  
A. I. Khalimon ◽  
A. V. Leontyev ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Renal Cell ◽  
Clinical Case ◽  
Clear Cell ◽  
Malignant Tumors ◽  
Metastatic Potential ◽  
Cell Renal Cell Carcinoma ◽  
Metastatic Lesions

This article presents a clinical case demonsratinga high metastatic potential of clear cell renal cell carcinoma combined with atypical metastases to breast and paranasal sinuses. The prevalence of metastatic lesions to the breast and paranasal sinuses in various malignant tumors depending on their morphological forms is analyzed. The authors present an analysis of data published for the last 30 years. The optimal diagnostic algorithms to detect the progression of renal cell carcinoma and to evaluate the effectiveness of the treatment are considered.

Clear cell adenocarcinoma of the tunica vaginalis of the testis with an adjacent uterus-like tissue*

2004 ◽  
Vol 54 (8) ◽  
pp. 641-647 ◽  
Author(s):  
Ozden Tulunay ◽  
Cagatay Gogus ◽  
Sumer Baltaci ◽  
Safak Bulut
Keyword(s):  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Tunica Vaginalis

scholarly journals Lipschütz Ulcer: An Unusual Diagnosis that Should Not be Neglected

2021 ◽  
Vol 43 (05) ◽  
pp. 414-416
Author(s):  
Daniela Alexandra Gonçalves Pereira ◽  
Eliana Patrícia Pereira Teixeira ◽  
Ana Cláudia Martins Lopes ◽  
Ricardo José Pina Sarmento ◽  
Ana Paula Calado Lopes
Keyword(s):  
Emergency Department ◽  
Differential Diagnosis ◽  
Clinical Course ◽  
Malignant Tumors ◽  
Sudden Onset ◽  
Drug Reactions ◽  
Genital Ulceration ◽  
Sexually Transmitted ◽  
Inflammatory Processes ◽  
Genital Ulcers

AbstractThe diagnosis of genital ulcers remains a challenge in clinical practice. Lipschütz ulcer is a non-sexually transmitted rare and, probably, underdiagnosed condition, characterized by the sudden onset of vulvar edema along with painful necrotic ulcerations. Despite its unknown incidence, this seems to be an uncommon entity, with sparse cases reported in the literature. We report the case of an 11-year-old girl who presented at the emergency department with vulvar ulcers. She denied any sexual intercourse. The investigation excluded sexually transmitted infections, so, knowledge of different etiologies of non-venereal ulcers became essential. The differential diagnoses are extensive and include inflammatory processes, drug reactions, trauma, and malignant tumors. Lipschütz ulcer is a diagnosis of exclusion. With the presentation of this case report, the authors aim to describe the etiology, clinical course, and outcomes of this rare disease, to allow differential diagnosis of genital ulceration.

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