scholarly journals Identificação dos Agrotóxicos Associados ao Desenvolvimento de Linfoma Não-Hodgkin

UNICIÊNCIAS ◽  
2021 ◽  
Vol 24 (1) ◽  
pp. 65-70
Author(s):  
Luiza Flavia Veiga Francisco ◽  
Rogério Nunes Da Silva ◽  
Jefferson Tennesse Da Silva Vicente ◽  
Lauriany Da Silva Pereira Damasceno ◽  
Tais Regina Mazaro Cangani ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Hodgkin Lymphoma ◽  
Environmental Contamination ◽  
Human Exposure ◽  
Dichlorophenoxyacetic Acid ◽  
Negative Effects ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Indirect Risk ◽  
2,4 Dichlorophenoxyacetic Acid

A agricultura é uma das principais fontes antrópicas relacionadas com a contaminação ambiental. A quantidade de agrotóxicos utilizados nesta produção vem sendo aumentada ao longo dos anos em paralelo com o crescimento populacional. Os resíduos destes produtos contaminam o solo, o ar e a água e, com isso, apresentam risco direto ou indireto para a saúde humana e ambiental. A exposição humana aguda e crônica a estes compostos está relacionada com diversos efeitos negativos à saúde humana. O Linfoma não-Hodgkin (LNH) é um dos tipos de câncer mais associado com a exposição ocupacional aos agrotóxicos. De acordo com o levantamento de estudos realizados, neste trabalho, nos quais associaram a exposição aos agrotóxicos com LNH, 21 agrotóxicos foram identificados como associados com este tipo de câncer. Os agrotóxicos Ácido 2,4-diclorofenoxiacético, Diazinon, Diclorodifeniltricloroetano, Glifosato e Lindano foram os que apareceram em maior frequência nos artigos analisados e a associação destes compostos específicos com o risco aumentado de subtipos de LNH já foi relatada em estudos anteriores. Diante do que abordado, neste trabalho, a realização de estudos, que avaliem os riscos para o desenvolvimento de LNH causados pela exposição aos agrotóxicos se tornam necessários, a fim de contribuir com a prevenção de câncer para as populações expostas.   Palavras-chave: Agricultura. Exposição Ocupacional. Inseticidas. Herbicidas. Câncer. Toxicidade.   Abstract Agriculture is one of the main human sources related to environmental contamination. The amount of pesticides used in this production has been increasing over the years in parallel with the increase of population. The residues of these products contaminate the soil, air and water and, therefore, present a direct or indirect risk to human and environmental health. Acute and chronic human exposure to these compounds is related to several negative effects on human health, such as the development of cancer. Non-Hodgkin Lymphoma (NHL) is one of the types of cancer most associated with occupational exposure to pesticides.  According to studies collected in this work, in which they associated exposure to pesticides with NHL, 21 pesticides were identified as associated with this type of cancer. The pesticides 2,4-dichlorophenoxyacetic acid, Diazinon, Dichlorodiphenyltrichloroethane, Glyphosate and Lindane were the ones that appeared with higher frequency in the analyzed articles and the association of these specific compounds with the increased risk of NHL subtypes has been reported in previous studies. Given what was addressed in this work, studies that assess the risks to  NHL development caused by exposure to pesticides are necessary in order to contribute to  cancer  prevention in exposed populations.   Keywords: Agriculture. Occupational Exposure. Insecticides. Herbicides. Cancer. Toxicity

scholarly journals 2,4-dichlorophenoxyacetic acid (2,4-D) and risk of non-Hodgkin lymphoma: a meta-analysis accounting for exposure levels

2017 ◽  
Vol 27 (4) ◽  
pp. 281-289.e4 ◽  
Author(s):  
Adam M. Smith ◽  
Martyn T. Smith ◽  
Michele A. La Merrill ◽  
Jane Liaw ◽  
Craig Steinmaus
Keyword(s):  
Hodgkin Lymphoma ◽  
Meta Analysis ◽  
Dichlorophenoxyacetic Acid ◽  
Non Hodgkin Lymphoma ◽  
Exposure Levels ◽  
2,4 Dichlorophenoxyacetic Acid

scholarly journals Increased risk of myelotoxicity in elderly patients with non-Hodgkin lymphoma

Cancer ◽  
2003 ◽  
Vol 100 (1) ◽  
pp. 6-11 ◽  
Author(s):  
Lodovico Balducci ◽  
Lazzaro Repetto
Keyword(s):  
Elderly Patients ◽  
Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk

scholarly journals Occupational Exposure to Solvents and Risk of Non-Hodgkin Lymphoma in Connecticut Women

2008 ◽  
Vol 169 (2) ◽  
pp. 176-185 ◽  
Author(s):  
R. Wang ◽  
Y. Zhang ◽  
Q. Lan ◽  
T. R. Holford ◽  
B. Leaderer ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma

Lifetime physical inactivity is associated with increased risk for Hodgkin and non-Hodgkin lymphoma: A case-control study

2018 ◽  
Vol 69 ◽  
pp. 7-11 ◽  
Author(s):  
John Lewis Etter ◽  
Rikki Cannioto ◽  
Kah Teong Soh ◽  
Emad Alquassim ◽  
Hani Almohanna ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Physical Inactivity ◽  
Case Control Study ◽  
Case Control ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Control Study

scholarly journals Increased Risk for Non-Hodgkin Lymphoma in Individuals With Celiac Disease and a Potential Familial Association

2009 ◽  
Vol 136 (1) ◽  
pp. 91-98 ◽  
Author(s):  
Ying Gao ◽  
Sigurdur Y. Kristinsson ◽  
Lynn R. Goldin ◽  
Magnus Björkholm ◽  
Neil E. Caporaso ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Hodgkin Lymphoma ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Familial Association

PERILOUS HIV BRINGS OUT DEADLY CANCERS

2020 ◽  
pp. 1-5
Author(s):  
Camila A Carlman ◽  
Bharat Mishra ◽  
Anita Patel
Keyword(s):  
Immune System ◽  
Hodgkin Lymphoma ◽  
Cancer Progression ◽  
Kaposi's Sarcoma ◽  
Cellular Proliferation ◽  
Kaposi’S Sarcoma ◽  
Hiv Patients ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
Risk Of Cancer

Human Immunodeficiency Virus (HIV) infection is both infectious and contagious disease. The people infected with HIV have an increased risk of cancer while comparing with uninfected people. Kaposi’s sarcoma, aggressive B-cell Non-Hodgkin Lymphoma & cervical cancer are the three types of cancers which are termed as “HIV –associated cancers”. Apart from these cancers, HIV patients are prone to cancers of anus, liver, lung, pharynx which are termed as “non-AIDS defining cancers”. Viral oncogenesis and cytokine induced growth contribute to the development of Kaposi sarcoma. Several virally encoded genes such as bcl-2, IL-6, cyclin-D, GPCR & interferon regulatory factor, plays key role in cellular proliferation and survival.  Infection with HIV weakens the immune system and reduces the body’s ability to fight against viral infections that may lead to cancer. Immunosuppression and inflammation in HIV patients also contribute to cancer progression. The complications of AIDS- related cancers include easy bleeding and bruising, tiredness, nausea, vomiting, poor appetite, mouth sores, hair loss etc. According to the data, HIV infected males are more susceptible to Kaposi’s sarcoma and Non- Hodgkin Lymphoma whereas females are more liable to cervical cancers. Early diagnosis and treatment options help to drop the risk of AIDS related cancers. The HAART therapy reduces the risk of cancer in HIV patients by lowering the amount of HIV circulating in blood, so that function of immune system to fight against the virus can be restored. Other treatment methods are chemotherapy, immunotherapy, radiation and surgery.

Childhood Crowding, Atopy and Risk of Non-Hodgkin Lymphoma.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 4648-4648
Author(s):  
Wendy Cozen ◽  
Engels A. Eric ◽  
James R. Cerhan ◽  
Martha Linet ◽  
Leslie Bernstein ◽  
...  
Keyword(s):  
Immune Response ◽  
Los Angeles ◽  
Follicular Lymphoma ◽  
Hodgkin Lymphoma ◽  
Health Care Financing ◽  
B Cell Lymphoma ◽  
Cancer Registries ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk ◽  
History Of

Abstract Subtle differences in immune response may play a role in non-Hodgkin lymphoma (NHL) etiology. Because adult immune response may be influenced by early childhood exposures, we examined the role of childhood crowding, history of atopic disease, and other childhood immune-related exposures on the risk of non-Hodgkin lymphoma in a multi-center case-control study. Interviews were completed with 1,321 cases ascertained from population-based cancer registries in Seattle, Detroit, Los Angeles and Iowa, and with 1,057 frequency-matched controls, selected by random-digit dialing and from the Health Care Financing Administration (HCFA) database. The association between NHL risk in relation to atopy and other exposures was assessed using multivariable logistic regression methods. Most types of allergy were associated with protection from NHL, with hay fever especially protective against all NHL combined (Odds Ratio [OR] = 0.71, 95% confidence interval [CI]= 0.54–0.94), diffuse large B-cell lymphoma [DLBCL] (OR=0.61, 95% CI=0.41–0.91), and follicular lymphoma (OR=0.70, 95% CI=0.45–1.09). A history of eczema increased risk of follicular lymphoma (OR=1.92, 95% CI= 1.08–3.41) but not DLBCL (OR=1.06, 95% CI= 0.55.2.04). Asthma in childhood was not associated with risk of NHL. Risk of DLBCL (OR =1.72, 95% CI=1.17–2.52), but not follicular lymphoma (OR=1.15, 95% CI=0.75–1.76) was elevated for the youngest compared to the oldest of siblings. Neither number of siblings nor years between births of siblings were significantly associated with risk. These results suggest that some immune-related exposures may affect NHL risk.

Cardiac Outcomes in a Prospective Cohort of Adult Non-Hodgkin Lymphoma Survivors

Blood ◽  
2011 ◽  
Vol 118 (21) ◽  
pp. 2656-2656
Author(s):  
Carrie A. Thompson ◽  
Hongxiu Luo ◽  
Matthew J Maurer ◽  
Cristine Allmer ◽  
Thomas M. Habermann ◽  
...  
Keyword(s):  
Heart Disease ◽  
Hodgkin Lymphoma ◽  
Valvular Heart Disease ◽  
Mayo Clinic ◽  
Cumulative Incidence ◽  
Medical Records ◽  
P Value ◽  
Non Hodgkin Lymphoma ◽  
Increased Risk

Abstract Abstract 2656 Background Treatment of non-Hodgkin lymphoma (NHL) can lead to development of cardiovascular disease (CVD). We sought to describe the cumulative incidence of CVD in adult NHL survivors diagnosed in the recent treatment era (since 2002) and identify clinical and treatment predictors for its development. Methods All patients were from the Mayo component of the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic Lymphoma Specialized Program of Research Excellence (SPORE). The MER offers enrollment to all consecutive patients with newly diagnosed NHL who are US residents and age >18 years. Clinical data from the time of diagnosis and treatment data are abstracted from medical records using a standard protocol. Patients are prospectively contacted via telephone or in person per protocol every 6 months for the first 3 years from diagnosis and yearly afterwards to assess disease status and development of comorbid conditions. CVD events, including heart failure (HF), myocardial infarction (MI), arrhythmia, pericarditis, and valvular heart disease, occurring after diagnosis were identified during follow-up and validated against medical records. HF was validated with the Cardiovascular Health Study Criteria and/or the Framingham Criteria. MI was validated using case definition standards of coronary heart disease, while arrhythmia, pericarditis, and valvular heart disease were validated using clinical definitions. The prevalence of CVD and associations between CVD and clinical characteristics (sex, age) and treatment (radiation, anthracyclines) were performed using Cox models with a competing risk approach. Results 1164 patients with NHL were enrolled into the MER at Mayo Clinic between 9/1/2002–2/28/2008. 646 were male (56%) and median age at diagnosis was 62 years (range 20–93). Median follow-up of all cases was 59 months (range 1–105). 131 patients reported CVD prior to the diagnosis of NHL and were excluded from analyses. An additional 76 patients did not have follow-up and were excluded. Of the 957 remaining patients, 75 (7.8%) self-reported a new diagnosis of CVD. Of these, 71 cases had available medical records. 57 of the 71 reviewed cases (80%) were validated (18 HF, 9 MI, 21 arrhythmia, 2 pericarditis, and 10 valvular heart disease). Cumulative incidence of CVD at 1, 3, 5, and 7 years was 1.3%, 3.7%, 5.2%, and 7.4%, respectively. Median time from NHL diagnosis to CVD was 26.5 months (range 1–84). Older age was associated with increased risk of overall CVD (p-value<0.001). Gender (p=0.59), radiation therapy (p=0.61), and anthracycline treatment (p=0.25) were not associated with the incidence of overall CVD. Among types of CVD, anthracycline use was associated with development of HF (HR=5.30; p-value=0.008) and arrhythmia (HR=2.68; p-value=0.04). Radiation was associated with development of arrhythmia (HR=2.73; p-value=0.03), while older age was associated with development of HF (HR=1.36 per 5 year increment; p-value=0.003) and arrhythmia (HR=1.25 per 5 year increment; p-value=0.02). Conclusions The risk of CVD in patients with NHL is approximately 1% per year after the initial diagnosis of lymphoma. The most commonly occurring CVDs in this cohort of NHL survivors were arrhythmia and HF. Treatment with anthracyclines and radiation are associated with increased risk of developing some types of CVD. 80% of self-reported CVD events in NHL survivors were validated using epidemiologic criteria. Future studies will include building models incorporating comorbid health conditions and lifestyle factors to determine risk of CVD as well as the impact of CVD on quality of life. Disclosures: No relevant conflicts of interest to declare.

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