Attaining Treatment Goals as a Measure of Therapy Benefits in Type 2 Diabetes

2008 ◽  
Vol 04 (01) ◽  
pp. 56
Author(s):  
Robert R Henry
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Environmental Factors ◽  
Genetic Predisposition ◽  
Cardiovascular Complications ◽  
Treatment Goals ◽  
Obesity Epidemic ◽  
Contributory Factors ◽  
The Us

Type 2 diabetes has reached epidemic proportions in the US,1and its prevalence will continue to grow unless contributory factors such as the obesity epidemic and our ever-more sedentary lifestyles are significantly addressed.2These environmental factors, together with genetic predisposition, increase the risk for insulin resistance and the development of diabetes, which in turn is associated with the development of microvascular and cardiovascular complications.

scholarly journals Genetic Predisposition to High Blood Pressure Associates With Cardiovascular Complications Among Patients With Type 2 Diabetes: Two Independent Studies

Diabetes ◽  
2012 ◽  
Vol 61 (11) ◽  
pp. 3026-3032 ◽  
Author(s):  
Q. Qi ◽  
J. P. Forman ◽  
M. K. Jensen ◽  
A. Flint ◽  
G. C. Curhan ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
High Blood Pressure ◽  
Genetic Predisposition ◽  
Cardiovascular Complications

scholarly journals Obesity and Insulin Resistance: An Abridged Molecular Correlation

2013 ◽  
Vol 6 ◽  
pp. LPI.S10805 ◽  
Author(s):  
Biswajit Mukherjee ◽  
Chowdhury M. Hossain ◽  
Laboni Mondal ◽  
Paramita Paul ◽  
Miltu K. Ghosh
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Molecular Mechanisms ◽  
Physiological Role ◽  
Cardiovascular Complications ◽  
Vital Role ◽  
Diabetic Patients ◽  
Predisposing Factor ◽  
Main Culprit

A relationship between obesity and type 2 diabetes is now generally well accepted. This relationship represents several major health hazards including morbid obesity and cardiovascular complications worldwide. Diabetes mellitus is a complex metabolic disorder characterized by impaired insulin release and insulin resistance. Lipids play an important physiological role in skeletal muscle, heart, liver and pancreas. Deregulation of fatty acid metabolism is the main culprit for developing insulin resistance and type 2 diabetes. A predominant predisposing factor to developing obesity, insulin resistance and type 2 diabetes is the permanent elevation of free fatty acids in plasma followed by impaired utilization of lipids by muscle. Diabetes-induced inflammation and oxidative stress have also vital role for development of insulin resistance in diabetic patients. The present review is intended to describe the correlation between lipids, obesity and insulin resistance based on current literature, in order to elucidate involved molecular mechanisms in depth.

scholarly journals Epidemiya ozhireniya: ochevidnye i veroyatnye prichiny

2011 ◽  
Vol 8 (1) ◽  
pp. 5-19 ◽  
Author(s):  
T I Romantsova
Keyword(s):  
Type 2 Diabetes ◽  
Environmental Factors ◽  
Key Factors ◽  
Gut Flora ◽  
Maternal Influences ◽  
Obesity Epidemic ◽  
Global Epidemic ◽  
Diet And Exercise ◽  
Abundant Evidence

Obesity and obesity-related disorders, such as type 2 diabetes, has become a global epidemic. Although there is abundant evidence that diet and exercise are key factors in the obesity epidemic, it is equally clear that a variety of environmental factors play an important role in this process. These include such factors as gut flora, insufficient sleep, stress, social environment, maternal influences, endocrine disrupters and others. These factors target key hormonal signaling pathways involved in adipogenesis, regulation of appetite. They are also likely to play important roles in obesity epidemic and are therefore worthy of further study.

scholarly journals Diabetes Genetic Predisposition Score and Cardiovascular Complications Among Patients With Type 2 Diabetes

Diabetes Care ◽  
2012 ◽  
Vol 36 (3) ◽  
pp. 737-739 ◽  
Author(s):  
Q. Qi ◽  
J. B. Meigs ◽  
K. M. Rexrode ◽  
F. B. Hu ◽  
L. Qi
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Predisposition ◽  
Cardiovascular Complications ◽  
Genetic Predisposition Score

scholarly journals Use of metformin in pediatric type 2 diabetes

2013 ◽  
Vol 20 (4) ◽  
pp. 435-439
Author(s):  
Diana Paun ◽  
Alexandra Bulgar
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Environmental Factors ◽  
Children And Adolescents ◽  
Clinical Use ◽  
Pancreatic Insulin ◽  
Prevalence Of Obesity ◽  
Genetic And Environmental Factors

Abstract In the last 10 years the incidence of type 2 diabetes (T2DM) in children and adolescents has increased, due to increasing prevalence of obesity in youth. Therefore, the prevalence of diabetes-related complications such as hypertension, hyperlipidemia and microalbuminuria has also increased in pediatric T2DM. The pathogenesis of T2DM in children involves genetic and environmental factors that will determine the increase of insulin resistance and decrease of beta pancreatic insulin secretion. Only metformin and insulin are approved for clinical use in children in the majority of countries. The aim of this paper is to review the benefits of the treatment with metformin in children and adolescents with T2DM.

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