scholarly journals Inhalation therapy in children: new opportunities

2019 ◽  
Vol 29 (4) ◽  
pp. 499-507
Author(s):  
Е. Е. Lokshina ◽  
О. V. Zaytseva
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Treatment Success ◽  
Dry Powder Inhaler ◽  
Delivery Systems ◽  
Inhalation Therapy ◽  
Inhalation Technique ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Inhalation Drug Delivery

Inhalation therapy is widely used for treatment of acute respiratory infections and asthma in children, and provides more rapid drug delivery in the airways. Treatment success in children with respiratory diseases is defined not only by an adequate choice of the drug and the dosage regimen, but also by inhalation drug delivery system. The choice of drug delivery device in children depends on the child's age and ability to carry out instructions related to the inhalation technique. Incorrect inhalation technique is associated with inappropriate distribution of the drug in the respiratory tract and an unreasonable increase in the volume of therapy, risk of adverse effects, and the total cost of the treatment. Currently, a great number of various drug delivery systems are commercially available, such as a pressurised metered dose inhaler (MDI), a MDI with spacer and facemask, a dry powder inhaler, and a nebulizer. The most optimal inhalation drug delivery device for children is a nebulizer. In this article, the authors discussed benefits and limitations of various drug delivery systems and modern nebulizers used for treatment of the upper and the lower airways including DuoBaby nebulizer 2-in-1 with a nasal aspirator. 

scholarly journals Advances of Microneedles in Biomedical Applications

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5912
Author(s):  
Jie Xu ◽  
Danfeng Xu ◽  
Xuan Xuan ◽  
Huacheng He
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Minimally Invasive ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Wound Repair ◽  
Delivery Systems ◽  
Delivery Device ◽  
Drug Delivery Device ◽  
Different Shapes

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

Biologically Inspired Robotic Microswimmers

2009 ◽  
Author(s):  
William R. Hesse ◽  
Matthew Federici ◽  
David M. Casale ◽  
Peter Fink ◽  
Basil Milton ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Reynolds Number ◽  
Drug Delivery Systems ◽  
Controlled Drug Delivery ◽  
Specific Cell ◽  
Delivery Device ◽  
Biologically Inspired ◽  
Profound Impact ◽  
Drug Delivery Device

Drug delivery systems have had a profound impact on several branches of medicine. Engineers and researchers alike have labored to create a controlled drug delivery device capable of regulated dosage release and a specific cell targeting mechanism. The growing field of biomimicry has inspired several of these drug systems, though success has been limited. The flagellated low Reynolds number propulsion system of Salmonella typhimurium has inspired this specific delivery complex. In this system, the helical flagellar filaments of S. typhimurium are isolated from the bacteria’s cell body and are bound to functionalized paramagnetic microspheres. As a magnetic field is applied to this device, the microsphere rotates, inducing rotation of the helical flagella. This motion creates a locomotive force and drives the device in a predestined direction.

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer

2006 ◽  
Vol 29 (5) ◽  
pp. 367-374 ◽  
Author(s):  
Samah Anabousi ◽  
Udo Bakowsky ◽  
Marc Schneider ◽  
Hanno Huwer ◽  
Claus-Michael Lehr ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Inhalation Therapy ◽  
In Vitro Assessment

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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