Advances of Microneedles in Biomedical Applications

A microneedle (MN) is a painless and minimally invasive drug delivery device initially developed in 1976. As microneedle technology evolves, microneedles with different shapes (cone and pyramid) and forms (solid, drug-coated, hollow, dissolvable and hydrogel-based microneedles) have been developed. The main objective of this review is the applications of microneedles in biomedical areas. Firstly, the classifications and manufacturing of microneedle are briefly introduced so that we can learn the advantages and fabrications of different MNs. Secondly, research of microneedles in biomedical therapy such as drug delivery systems, diagnoses of disease, as well as wound repair and cancer therapy are overviewed. Finally, the safety and the vision of the future of MNs are discussed.

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Inhalation therapy in children: new opportunities

Russian Pulmonology ◽

10.18093/0869-0189-2019-29-4-499-507 ◽

2019 ◽

Vol 29 (4) ◽

pp. 499-507

Author(s):

Е. Е. Lokshina ◽

О. V. Zaytseva

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Treatment Success ◽

Dry Powder Inhaler ◽

Delivery Systems ◽

Inhalation Therapy ◽

Inhalation Technique ◽

Delivery Device ◽

Drug Delivery Device ◽

Inhalation Drug Delivery

Inhalation therapy is widely used for treatment of acute respiratory infections and asthma in children, and provides more rapid drug delivery in the airways. Treatment success in children with respiratory diseases is defined not only by an adequate choice of the drug and the dosage regimen, but also by inhalation drug delivery system. The choice of drug delivery device in children depends on the child's age and ability to carry out instructions related to the inhalation technique. Incorrect inhalation technique is associated with inappropriate distribution of the drug in the respiratory tract and an unreasonable increase in the volume of therapy, risk of adverse effects, and the total cost of the treatment. Currently, a great number of various drug delivery systems are commercially available, such as a pressurised metered dose inhaler (MDI), a MDI with spacer and facemask, a dry powder inhaler, and a nebulizer. The most optimal inhalation drug delivery device for children is a nebulizer. In this article, the authors discussed benefits and limitations of various drug delivery systems and modern nebulizers used for treatment of the upper and the lower airways including DuoBaby nebulizer 2-in-1 with a nasal aspirator.

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Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

Marine Drugs ◽

10.3390/md18070346 ◽

2020 ◽

Vol 18 (7) ◽

pp. 346 ◽

Cited By ~ 2

Author(s):

Simone S. Silva ◽

Joana M. Gomes ◽

Luísa C. Rodrigues ◽

Rui L. Reis

Keyword(s):

Drug Delivery ◽

Ionic Liquids ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Wound Repair ◽

Marine Resources ◽

Considerable Potential ◽

Efficient Extraction ◽

Different Shapes ◽

Or Gene

Marine resources have considerable potential to develop high-value materials for applications in different fields, namely pharmaceutical, environmental, and biomedical. Despite that, the lack of solubility of marine-derived polymers in water and common organic solvents could restrict their applications. In the last years, ionic liquids (ILs) have emerged as platforms able to overcome those drawbacks, opening many routes to enlarge the use of marine-derived polymers as biomaterials, among other applications. From this perspective, ILs can be used as an efficient extraction media for polysaccharides from marine microalgae and wastes (e.g., crab shells, squid, and skeletons) or as solvents to process them in different shapes, such as films, hydrogels, nano/microparticles, and scaffolds. The resulting architectures can be applied in wound repair, bone regeneration, or gene and drug delivery systems. This review is focused on the recent research on the applications of ILs as processing platforms of biomaterials derived from marine polymers.

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Environment-responsive Polymeric Nanoparticles as Drug Delivery Systems for Cancer Therapy

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1206.2013.00431 ◽

2013 ◽

Vol 40 (10) ◽

pp. 1039

Author(s):

Yang YANG ◽

Wen-Chuan SHE ◽

Kui LUO ◽

Zhong-Wei GU

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Polymeric Nanoparticles ◽

Delivery Systems

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Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy

Current Drug Targets ◽

10.2174/1389450121666200514222900 ◽

2020 ◽

Vol 21 (11) ◽

pp. 1084-1098

Author(s):

Fengqian Chen ◽

Yunzhen Shi ◽

Jinming Zhang ◽

Qi Liu

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Cancer Therapy ◽

Drug Delivery Systems ◽

Therapeutic Index ◽

Delivery Systems ◽

Epigenetic Therapy ◽

Cancer Therapies ◽

Therapeutic Benefits ◽

High Therapeutic Index

This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery systems with epigenetic therapy is a promising approach to reaching a high therapeutic index and minimizing the side effects.

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Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

Current Drug Targets ◽

10.2174/1389450121666200611140425 ◽

2020 ◽

Vol 21 ◽

Author(s):

Dickson Pius Wande ◽

Qin Cui ◽

Shijie Chen ◽

Cheng Xu ◽

Hui Xiong ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Drug Dissolution ◽

Glycol Succinate ◽

Permeation Enhancer ◽

P Glycoprotein ◽

Us Fda ◽

Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

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STING-activating drug delivery systems: Design strategies and biomedical applications

Chinese Chemical Letters ◽

10.1016/j.cclet.2021.01.001 ◽

2021 ◽

Author(s):

Chunying Li ◽

Yifan Zhang ◽

Yilin Wan ◽

Jingle Wang ◽

Jing Lin ◽

...

Keyword(s):

Drug Delivery ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Systems Design ◽

Delivery Systems ◽

Design Strategies

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Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

Biomaterials Science ◽

10.1039/c7bm01113j ◽

2018 ◽

Vol 6 (4) ◽

pp. 877-884 ◽

Cited By ~ 24

Author(s):

Po Li ◽

Yue Yan ◽

Binlong Chen ◽

Pan Zhang ◽

Siling Wang ◽

...

Keyword(s):

Drug Delivery ◽

Fluorescence Imaging ◽

Photothermal Therapy ◽

Biomedical Applications ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Research Interest ◽

Upconversion Nanoparticles ◽

Multifunctional Nanoparticles ◽

Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

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