Increased manganese superoxide dismutase and cyclin B1 expression in carnosine-induced inhibition of glioblastoma cell proliferation
2015 ◽
Vol 61
(4)
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pp. 510-518
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Keyword(s):
Carnosine is an endogenous dipeptide with antiproliferative properties. Here we show that carnosine selectively inhibits proliferation of human glioblastoma cells (U-118-MG) compared to breast (MB231) and oral (Cal27 and FaDu) cancer cells. Carnosine-induced inhibition of U-118-MG proliferation is associated with a significant: decrease in cellular reactive oxygen species levels, increase in manganese superoxide dismutase (MnSOD) and increase in cyclin B1 expression resulting in G2-block. We conclude that the antiproliferative property of carnosine is due to its ability to enhance MnSOD and cyclin B1 expression. These results will be of significance to the potential application of carnosine in brain cancer therapy
2009 ◽
Vol 41
(5)
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pp. 1002-1005
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2010 ◽
Vol 48
(10)
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pp. 1321-1329
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2000 ◽
Vol 48
(3)
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pp. 276-277
2017 ◽
Vol 1858
(8)
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pp. 628-632
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1998 ◽
Vol 177
(1)
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pp. 148-160
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2002 ◽
Vol 55
(3)
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pp. 495-505
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2002 ◽
Vol 277
(23)
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pp. 20919-20926
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2009 ◽
Vol 14
(6)
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pp. 579-589
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