scholarly journals The imbalance of metal-containing proteins and free metal ions in the amniotic fluid during fetal growth

2016 ◽  
Vol 62 (1) ◽  
pp. 69-72 ◽  
Author(s):  
T.N. Pogorelova ◽  
V.A. Linde ◽  
V.O. Gunko ◽  
S.N. Selyutina
Keyword(s):  
Amniotic Fluid ◽  
Metal Ions ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Copper Content ◽  
Developmental Disorders ◽  
Normal Pregnancy ◽  
Fetal Growth Retardation ◽  
Magnesium Ions ◽  
Free Metal

The levels of zinc, copper, iron, and magnesium ions, and some of their binding proteins have been investigated in an amniotic fluid under the fetal growth retardation (FGR). FGR, developed under conditions of placental insufficiency, is characterized by a decrease in the content of zinc, iron, and magnesium ions and by an increase in the copper content in the amniotic fluid in the II and III trimesters of pregnancy. During these trimesters the levels of ceruloplasmin, ferritin, and Ca2+,Mg2+-ATPase were lower in FGR, while the level of zinc-a-2-glycoprotein was higher than during the same periods of normal pregnancy. Changes in the parameters studied in the amniotic fluid were associated with developmental disorders of the newborns. These changes obviously have a pathogenetic importance in the development of FGR, and the levels of metal ions and their ratio in the amniotic fluid can be used as markers of the pre- and postnatal pathology.

scholarly journals 44 Oxidative Stress in Amniotic Fluid of Pregnancies with Fetal Growth Retardation

2004 ◽  
Vol 56 (3) ◽  
pp. 471-471 ◽  
Author(s):  
M Longini ◽  
S Perrone ◽  
A Kenanidis ◽  
P Vezzosi ◽  
B Marzocchi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Amniotic Fluid ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Fetal Growth Retardation

Decreased Expression of PAI-2 mRNA and Protein in Pregnancies Complicated with Intrauterine Fetal Growth Retardation

1996 ◽  
Vol 76 (05) ◽  
pp. 761-767 ◽  
Author(s):  
Salvador Grancha ◽  
Amparo Estellés ◽  
Juan Gilabert ◽  
Melitina Chirivella ◽  
Francisco España ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Plasma Levels ◽  
Cell Types ◽  
Normal Pregnancy ◽  
High Plasma ◽  
Fetal Growth Retardation

SummaryAn increase in plasma plasminogen activator inhibitors (PAIs), fundamentally PAI type 2 (PAI-2), has been described in normal pregnancy probably because the placenta is the main source of the high plasma levels of this protein. Although we have previously described plasmatic alterations of these inhibitors in pregnancies complicated with intrauterine fetal growth retardation (IUGR), no reports have been published about placental PAI-2 mRNA expression. In the present study, the placental PAI-2 expression determined in pregnancies complicated with IUGR and in severe preeclamptic patients was compared with that of normal pregnancies in order to identify the placental cell types expressing PAI-2 and to determine whether the production of PAI-2 is altered in placentas from IUGR. In situ hybridization analyses show that the syncytiotrophoblasts are the cells with the greatest PAI-2 expression in placenta. We report that the significant decrease in plasma and placental PAI-2 levels in IUGR groups is fundamentally due to a diminished expression of PAI-2 mRNA in placenta.

scholarly journals FEATURES OF THE CLINICAL COURSE OF PREGNANCY, CHILDBIRTH IN WOMEN WITH COVID-19 AT DIFFERENT PERIODS OF GESTATION

2021 ◽  
pp. 39-47
Author(s):  
V. P. MISHCHENKO ◽  
I. L. GOLOVATYUK-YUZEFPOLSKAYA ◽  
I. RUDENKO ◽  
M. A. KARLYUGA ◽  
A. D. DIZIK ◽  
...  
Keyword(s):  
Amniotic Fluid ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Premature Birth ◽  
Clinical Course ◽  
Fetal Distress ◽  
Fetal Growth Retardation ◽  
Second Trimester ◽  
Placental Dysfunction ◽  
Threatened Abortion

The study of the features of the clinical course of pregnancy, childbirth in women who have had COVID-19 at different periods of gestation is relevant, especially in the context of a modern pandemic. Purpose of work. To determine the features of the clinical course of pregnancy, childbirth in women with COVID-19 at different periods of gestation. Materials and methods. 57 women who were ill with Covid-19 at different stages of pregnancy were examined. Results and discussion. The peculiarities of the clinical course of pregnancy, childbirth in women who have undergone Covid-19 diseases in the 1st trimesterinclude the syndrome of threatened abortion (73.6 %), placental dysfunction (100%), fetal growth retardation syndrome (42.9 %); in the second trimester - syndrome of threatened premature birth (55.6 %), placental dysfunction (100 %), amniotic fluid pathology (63.2 %); in the third trimester - anemia - in 100 %, antenatal fetal distress - in 42.1 %, pareclampsia - in 47.4 %, pathological blood loss - in 26.3 %. Conclusions. The course of pregnancy and childbirth in women who have undergone COVID-19 diseases in different trimesters of gestation have certain clinical features. Gestational complications in women who were ill in the early stages of the first trimester include the syndrome of threatened abortion, spontaneous abortion, missed abortion, premature birth in the second trimester, fetal growth retardation syndrome in the second and third trimesters. The gestational complications in women who were ill in the second trimester include the syndrome of threatened abortion, premature birth, pathology of amniotic fluid (amniotic fluid of «black» color), the phenomenon of angiitis in the abdominal cavity, placental dysfunction, fetal growth retardation syndrome, distress fetus, antenatal fetal death. The gestational complications in women who were ill in the third trimester include the syndrome of threatened premature birth, placental dysfunction, and fetal distress.

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