Decreased Expression of PAI-2 mRNA and Protein in Pregnancies Complicated with Intrauterine Fetal Growth Retardation

1996 ◽  
Vol 76 (05) ◽  
pp. 761-767 ◽  
Author(s):  
Salvador Grancha ◽  
Amparo Estellés ◽  
Juan Gilabert ◽  
Melitina Chirivella ◽  
Francisco España ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Plasma Levels ◽  
Cell Types ◽  
Normal Pregnancy ◽  
High Plasma ◽  
Fetal Growth Retardation

SummaryAn increase in plasma plasminogen activator inhibitors (PAIs), fundamentally PAI type 2 (PAI-2), has been described in normal pregnancy probably because the placenta is the main source of the high plasma levels of this protein. Although we have previously described plasmatic alterations of these inhibitors in pregnancies complicated with intrauterine fetal growth retardation (IUGR), no reports have been published about placental PAI-2 mRNA expression. In the present study, the placental PAI-2 expression determined in pregnancies complicated with IUGR and in severe preeclamptic patients was compared with that of normal pregnancies in order to identify the placental cell types expressing PAI-2 and to determine whether the production of PAI-2 is altered in placentas from IUGR. In situ hybridization analyses show that the syncytiotrophoblasts are the cells with the greatest PAI-2 expression in placenta. We report that the significant decrease in plasma and placental PAI-2 levels in IUGR groups is fundamentally due to a diminished expression of PAI-2 mRNA in placenta.

scholarly journals The imbalance of metal-containing proteins and free metal ions in the amniotic fluid during fetal growth

2016 ◽  
Vol 62 (1) ◽  
pp. 69-72 ◽  
Author(s):  
T.N. Pogorelova ◽  
V.A. Linde ◽  
V.O. Gunko ◽  
S.N. Selyutina
Keyword(s):  
Amniotic Fluid ◽  
Metal Ions ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Copper Content ◽  
Developmental Disorders ◽  
Normal Pregnancy ◽  
Fetal Growth Retardation ◽  
Magnesium Ions ◽  
Free Metal

The levels of zinc, copper, iron, and magnesium ions, and some of their binding proteins have been investigated in an amniotic fluid under the fetal growth retardation (FGR). FGR, developed under conditions of placental insufficiency, is characterized by a decrease in the content of zinc, iron, and magnesium ions and by an increase in the copper content in the amniotic fluid in the II and III trimesters of pregnancy. During these trimesters the levels of ceruloplasmin, ferritin, and Ca2+,Mg2+-ATPase were lower in FGR, while the level of zinc-a-2-glycoprotein was higher than during the same periods of normal pregnancy. Changes in the parameters studied in the amniotic fluid were associated with developmental disorders of the newborns. These changes obviously have a pathogenetic importance in the development of FGR, and the levels of metal ions and their ratio in the amniotic fluid can be used as markers of the pre- and postnatal pathology.

scholarly journals Effects of maternal iron restriction in the rat on hypoxia-induced gene expression and fetal metabolite levels

2001 ◽  
Vol 85 (2) ◽  
pp. 193-201 ◽  
Author(s):  
Rohan M. Lewis ◽  
Lynwen A. James ◽  
Junlong Zhang ◽  
Christopher D. Byrne ◽  
C. Nicholas Hales
Keyword(s):  
Amino Acids ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Plasma Levels ◽  
Plasma Cholesterol ◽  
Maternal Plasma ◽  
Fetal Growth Retardation ◽  
Restricted Diet ◽  
Fetal Plasma ◽  
Restricted Group

The mechanism by which maternal Fe deficiency in the rat causes fetal growth retardation has not been clearly established. This study compared the effects on the fetuses from dams fed a control diet with two groups of dams fed Fe-restricted diets. One Fe-restricted group was fed the Fe-restricted diet for 1 week prior to mating and throughout gestation and the second Fe-restricted group was fed the Fe-restricted diet for 2 weeks prior to mating and throughout gestation. On day 21 of gestation Fe-restricted dams, and their fetuses, were anaemic. Fetal weight was reduced in both Fe-restricted groups compared with controls. Expression of hypoxia-inducible factor (HIF)-1α and vascular endothelial growth factor (VEGF) are induced by hypoxia. The levels of HIF-1α mRNA were highest in placenta, then in kidney, heart and liver but were not different between the groups. Levels of plasma VEGF were not different between the groups. Maternal plasma triacylglycerol was decreased in the 1-week Fe-restricted dams compared with controls. Maternal plasma cholesterol and free fatty acid levels were not different between the groups. In fetal plasma, levels of triacylglycerol and cholesterol were decreased in both Fe-restricted groups. In maternal plasma, levels of a number of amino acids were elevated in both Fe-restricted groups. In contrast, levels of a number of amino acids in fetal plasma were lower in both Fe-restricted groups. Fetal plasma lactate was increased in Fe-restricted fetuses but fetal plasma glucose and β-hydroxybutyrate were not affected. These changes in fetal metabolism may contribute to fetal growth retardation in this model. This study does not support the hypothesis that the Fe-restricted fetus is hypoxic.

A Prospective Study of Haemostatic Tests at 28 Weeks Gestation as Predictors of Pre-Eclampsia and Growth Retardation

1989 ◽  
Vol 61 (02) ◽  
pp. 243-245 ◽  
Author(s):  
J G Thornton ◽  
B J Molloy ◽  
P S Vinall ◽  
P R Philips ◽  
R Hughes ◽  
...  
Keyword(s):  
Discriminant Analysis ◽  
Prospective Study ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Degradation Products ◽  
Fetal Growth Retardation ◽  
Fibrin Degradation Products ◽  
A Prospective Study ◽  
Primiparous Women ◽  
Significant Model

SummaryA panel of haemostatic tests was perfomed on 400 primiparous women at 28 weeks to test whether one or more could predict the development of pregnancy complications. Fifteen women subsequently developed pre-eclampsia with significant proteinuria and 13 delivered growth retarded infants. There were no significant differences between mothers in the pre-eclampsia group and 22 randomly selected controls. A stepwise logistic discriminant analysis of the data did not produce a significant model. In the growth retarded group only beta thromboglobulin levels were significantly lower than in the controls (p <0.05), although in the logistic discriminant analysis the inclusion of both beta thromboglobulin and fibrin degradation products led to a borderline significant improvement in fit of the model. We conclude that the haemostatic variables studied are not significantly changed at 28 weeks nor clinically useful predictors of either pre-eclampsia or fetal growth retardation.

Uteroplacental hemodynamic disturbances in establishment of fetal growth retardation in streptozocin-induced diabetic rats

Diabetes ◽  
1990 ◽  
Vol 39 (6) ◽  
pp. 743-746 ◽  
Author(s):  
N. C. Chartrel ◽  
M. T. Clabaut ◽  
F. A. Boismare ◽  
J. C. Schrub
Keyword(s):  
Fetal Growth ◽  
Growth Retardation ◽  
Diabetic Rats ◽  
Fetal Growth Retardation

VITAMIN D DEFICIENCY AND SYNDROME FETAL GROWTH RETARDATION

2020 ◽  
Vol 22 (3) ◽  
pp. 13-17
Author(s):  
Bushueva E.V. ◽  
◽  
Levitskaya V.M. ◽  
Boboeva Sh.G. ◽  
Sidorova T.N. ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Fetal Growth ◽  
Growth Retardation ◽  
Fetal Growth Retardation

Complex approach in the diagnosis of the fetal growth retardation syndrome

2018 ◽  
Vol 16 (6) ◽  
pp. 52-55
Author(s):  
E. V. Ulyanina ◽  
◽  
G. V. Akopyan ◽  
N. R. Akhmadeev ◽  
◽  
...  
Keyword(s):  
Fetal Growth ◽  
Growth Retardation ◽  
Fetal Growth Retardation ◽  
Complex Approach
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