The spontaneous motor activity of aqueous extract of Withania coagulans fruits in Swiss albino mice by actophotometer

Background: People spend about one third of their time in sleep every day. The various sedative and hypnotic medications used today have numerous side effects. In the late seventies a very little work was done on the Withania coagulans - a vulnerable species that is found scattered in the world. Therefore, it was essential to discover the CNS depressant activities of aqueous extract of Withania coagulans fruits in swiss albino mice by using actophotometer.Methods: The spontaneous locomotor activity was evaluated by using the actophotometer. The CNS depressant drugs decrease the locomotor activity in mice as they impair the motor coordination so that mice stay at one place for the longer time. Therefore, there is less disruption of the beams of light. This spontaneous locomotor activity time is statistically correlated among the control, standard and the test drugs.Results: There was statistically highly significant (p value <0.001) association observed between aqueous extract of Withania coagulans fruits with spontaneous locomotor activity in swiss albino mice on the actophotometer.Conclusions: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in swiss albino mice by actophotometer.

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The Motor Coordination Activity Of Aqueous Extract Of Withania Coagulans Fruits In Swiss Albino Mice By Rota Rod Test

European Journal of Medical and Health Sciences ◽

10.24018/ejmed.2020.2.3.255 ◽

2020 ◽

Vol 2 (3) ◽

Author(s):

Amit Shankarrao Kamdi ◽

Devesh D. Gosavi ◽

Suvarna M. Kalambe ◽

Pankaj N. Bohra

Keyword(s):

Aqueous Extract ◽

Motor Coordination ◽

P Value ◽

Endurance Time ◽

Swiss Albino Mice ◽

Cns Depressant ◽

Withania Coagulans ◽

Rota Rod Test ◽

Albino Mice ◽

Cns Depressant Activity

Background: The various sedative and hypnotic medications used today have the central nervous system (CNS) depressant effects. A very little work has been done on the Withania coagulans – a vulnerable species as it is not found rampant in the world except in late seventies. Therefore, it was important to explore the CNS depressant activities of aqueous extract of Withania coagulans fruits in Swiss albino mice by using rota rod test. Methods: Motor coordination was assessed by using the Rota Rod Test. The CNS depressant drugs decrease the endurance time of mice on the rota rod as they impair the motor coordination so that mice fall early on the rotating rod. This endurance time is statistically correlated among the control, standard and the test drugs. Results: There was statistically highly significant (p-value < 0.001) association observed between aqueous extract of Withania coagulans fruits with endurance time in Swiss albino mice on rota rod test. Conclusion: The aqueous extract of Withania coagulans fruits demonstrated the CNS depressant activity in Swiss albino mice by rota rod test.

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The antianxiety activity of aqueous extract of Withania coagulans fruits in swiss albino mice by elevated plus maze

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20203617 ◽

2020 ◽

Vol 9 (9) ◽

pp. 1337

Author(s):

Devesh D. Gosavi ◽

Amit S. Kamdi ◽

Suvarna M. Kalambe ◽

Pankaj N. Bohra

Keyword(s):

Aqueous Extract ◽

Open Space ◽

Elevated Plus Maze ◽

P Value ◽

Swiss Albino Mice ◽

Elevated Plus Maze Test ◽

Maze Test ◽

Withania Coagulans ◽

Plus Maze ◽

Albino Mice

Background: Several anti-anxiety drugs used today have the numerous side effects. The Withania coagulans a rare species, is not studied much for its actions on anxiety except in late seventies where it was explored for neuropsychopharmacology. Thus, it was thought commendable to explore the anti-anxiety activities of aqueous extract of Withania coagulans fruits in swiss albino mice using elevated plus maze test.Methods: Elevated plus maze (EPM) test was used for evaluating the anti-anxiety action of Withania coagulans fruits’ aqueous extract. If the extract had anti-anxiety action, then it was expected that the time spent in the open space would increase and that in the closed space would decrease. This increase in time in the open space, if found statistically significant, was considered for antianxiety action.Results: There was statistically highly significant (p value <0.001) association observed between the aqueous extract of Withania coagulans fruits with antianxiety action in the swiss albino mice by elevated plus maze test.Conclusions: The aqueous extract of Withania coagulans fruits did prove the antianxiety effect in the swiss albino mice by elevated plus maze test.

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The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20184852 ◽

2018 ◽

Vol 7 (12) ◽

pp. 2389

Author(s):

Amit S. Kamdi ◽

Sarika D. Kokane ◽

Pankaj N. Bohra ◽

Suvarna M. Kalambe

Keyword(s):

Avoidance Response ◽

Conditioned Avoidance ◽

Conditioned Avoidance Response ◽

P Value ◽

Alcoholic Extract ◽

Swiss Albino Mice ◽

Withania Coagulans ◽

Antipsychotic Activity ◽

Albino Mice ◽

Cns Effects

Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.

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The motor coordination activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by rota rod test

Indian Journal of Pharmacy and Pharmacology ◽

10.18231/j.ijpp.2020.015 ◽

2020 ◽

Vol 7 (2) ◽

pp. 73-76

Author(s):

Amit S Kamdi ◽

Devesh D Gosavi ◽

Suvarna M Kalambe ◽

Pankaj N Bohra ◽

Keyword(s):

Motor Coordination ◽

Alcoholic Extract ◽

Swiss Albino Mice ◽

Withania Coagulans ◽

Rota Rod Test ◽

Albino Mice ◽

Coordination Activity

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Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

Asian Pacific Journal of Tropical Disease ◽

10.1016/s2222-1808(14)60594-6 ◽

2014 ◽

Vol 4 (5) ◽

pp. 398-400 ◽

Cited By ~ 6

Author(s):

Annie George ◽

Sasikala Chinnappan ◽

Yogendra Choudhary ◽

Praveen Bommu ◽

Murthy Sridhar

Keyword(s):

Aqueous Extract ◽

Immunomodulatory Activity ◽

Swiss Albino Mice ◽

Carbon Clearance ◽

Polygonum Minus ◽

Albino Mice

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Effect of aqueous Extract of Terminalia bellirica fruit pulp on Alcohol affected learning in swiss albino mice

IP International Journal of Comprehensive and Advanced Pharmacology ◽

10.18231/j.ijcaap.2021.013 ◽

2021 ◽

Vol 6 (2) ◽

pp. 76-78

Author(s):

Sowmya ◽

Manohar VR ◽

Mohandas Rai ◽

H N Gopalakrishna ◽

Chandrashekar R

Keyword(s):

Aqueous Extract ◽

Protective Action ◽

Negative Control ◽

Control Group ◽

Acute Administration ◽

Aqueous Extracts ◽

Swiss Albino Mice ◽

Alcohol Administration ◽

Group I ◽

Albino Mice

To evaluate the effect of Aqueous extract of Terminalia belliricafruit pulp (AETB) on learning by Hebb William maze model in mice with acute alcohol consumption.Swiss albino mice (n=48) of either sex weighing 20-30g will be divided into eight groups of six mice each. Drugs were given orally after 12 hours of fasting. Group I mice received 10ml/kg of Normal Saline, Group II mice received Piracetam 200mg/kg, Group III received AETB 36mg/kg, Group IV received ethanol 1.5g/kg orally, Group V received ethanol(1.5g/kg )+ piracetam (200mg/kg), Group VI mice received ethanol(1.5g/kg) +AETB(9mg/kg), Group VII mice received ethanol(1.5g/kg) +AETB (18mg/kg), Group VIII mice received ethanol(1.5g/kg) +AETB(36mg/kg). Time taken by the animal to reach the reward chamber from the start chamber (TRC) in Hebb-William maze was used as a parameterto evaluate the learning.Acute alcohol administration showed increase in TRC. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp showed a decrease in TRC when compared to the control group. The TRC values for the groups that were administered AETB along with acute alcohol administration showed decrease in TRC values compared to the negative control.Current study showed acute alcohol administration caused impairment of thelearning ability in mice. Whereas, acute administration of Aqueous extracts of Terminalia belliricafruit pulp (AETB)caused enhancement of learning. Pre-treatment with AETB before acute alcohol administration indicated protective action of AETB on alcohol affected learning in mice.

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