scholarly journals Maternal and fetal outcome in liver disorders in pregnancy

2021 ◽  
Vol 10 (9) ◽  
pp. 1121
Author(s):  
Ruksana Farooq ◽  
Mehbooba Beigh ◽  
Rahat Abbas ◽  
Yusra Amin
Keyword(s):  
Perinatal Asphyxia ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Fetal Outcome ◽  
P Value ◽  
Normal Liver Function ◽  
Liver Disorders ◽  
Pregnancy And Postpartum ◽  
Fetal Complications ◽  
In Pregnancy

Background: Liver disorders comprise 3% of all pregnancy complications. All liver disorders, pregnancy specific, pregnancy related and pregnancy unrelated disorders have both maternal and fetal effects. The aim of the study was to determine the effect of liver disorders in pregnancy. The objective of this study was to determine the effect of liver disorders on pregnancy outcome.Methods: All pregnant patients with clinical and biochemical evidence of liver dysfunction were taken as cases. Pregnant women with normal liver function tests were taken as controls. All patients were followed during pregnancy and postpartum. Maternal and fetal outcome was studied.Results: A total of 140 patients were included- 70 cases and 70 controls. Maternal and fetal outcome was studied in both the groups. PPH and oligohydroamnios were most frequent among cases with p value of 0.034 and 0.035 respectively. Similarly, pre-term birth, RDS and perinatal asphyxia was more common in cases with a p value of 0.011, 0.001 and 0.005 respectively.Conclusions: Study concludes that liver disorders in pregnancy have adverse maternal and fetal complications. 

Management of Obscurely Dilated Common Bile Duct with Normal Liver Function Tests: A Pragmatic Approach

2021 ◽  
Author(s):  
Sundeep Singh Saluja ◽  
Vaibhav Kumar Varshney ◽  
Vidya Sharada Bhat ◽  
Phani Kumar Nekarakanti ◽  
Asit Arora ◽  
...  
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Liver Function ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Pragmatic Approach ◽  
Normal Liver Function ◽  
Function Tests

Persistently raised aspartate aminotransferase (AST) due to macro-AST in a rheumatology clinic

Diagnosis ◽  
2015 ◽  
Vol 2 (2) ◽  
pp. 137-140 ◽  
Author(s):  
Wycliffe Mbagaya ◽  
Joanne Foo ◽  
Ahai Luvai ◽  
Claire King ◽  
Sarah Mapplebeck ◽  
...  
Keyword(s):  
Liver Function ◽  
Aspartate Aminotransferase ◽  
Normal Liver ◽  
Abdominal Ultrasound ◽  
Liver Function Tests ◽  
Analytical Investigation ◽  
Normal Liver Function ◽  
Rheumatology Clinic ◽  
History Of ◽  
Liver Biopsies

AbstractMacrocomplexes between immunoglobins and aspartate aminotransferase (macro-AST) may result in persistently increased AST concentration. The presence of macro-AST in patients has been implicated in unnecessary investigations of abnormal liver function tests. We report the case of a 44-year-old female who presented to the rheumatology clinic with a 12-months’ history of constant widespread pain affecting her limbs and was found to have an elevated AST concentration. Further information from her GP revealed a 14-years’ history of elevated AST with otherwise normal liver function. Previous abdominal ultrasound and two liver biopsies carried out 2 years apart were normal. This prompted further analytical investigation by the biochemistry department which identified macro-AST as the cause. This case illustrates that persistently raised isolated AST concentration with no other abnormal indices may warrant macroenzyme analysis potentially avoiding unnecessary invasive investigations.

The liver in pregnancy

2013 ◽  
pp. 309-318
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Liver Disease ◽  
Hyperemesis Gravidarum ◽  
Gallstone Disease ◽  
Liver Function Tests ◽  
The Other ◽  
Liver Disorders ◽  
Hepatic Rupture ◽  
Chiari Syndrome ◽  
Acute Fatty Liver ◽  
In Pregnancy

Liver disease in pregnancy Liver function tests in pregnancy Hyperemesis gravidarum Obstetric cholestasis Acute fatty liver of pregnancy Pre-eclampsia HELLP syndrome Spontaneous hepatic rupture Gallstone disease Pancreatitis Budd–Chiari syndrome Viral hepatitis Pre-existing cirrhotic liver disease A number of liver disorders are unique to, or more likely to occur in, pregnancy. These should be considered alongside the other causes of liver disease that occur in non-pregnant patients. Transient mild derangements of LFT are common and rarely require further assessment beyond repeat monitoring to ensure normalization. However, liver disorders in pregnancy often present non-specifically and, therefore. all patients merit formal clinical assessment....

scholarly journals Bilirubin Metabolism — Preliminary Investigation

1976 ◽  
Vol 3 (4) ◽  
pp. 365-372 ◽  
Author(s):  
A. Barbeau ◽  
G. Breton ◽  
B. Lemieux ◽  
R.F. Butterworth
Keyword(s):  
Liver Function ◽  
Membrane Transport ◽  
Total Bilirubin ◽  
Preliminary Investigation ◽  
Normal Liver ◽  
Liver Function Tests ◽  
Bimodal Distribution ◽  
Secondary Component ◽  
Normal Liver Function ◽  
Bilirubin Metabolism

SUMMARY:In our studies, high total bilirubin values in the plasma were noted in cases of Friedreich's ataxia. A bimodal distribution of the values indicated the possible presence of two subgroups of patients. In these kindred, we demonstrated an elevation in unconjugated bilirubin with features similar to those reported in Gilbert's syndrome: normal liver function tests, elevation after fasting and day to day variability. We also report preliminary experiments indicating that bilirubin levels may be taurine dependent. We postulate that the defect could be a secondary component of the ataxic disease, possibly indicating a defect in membrane transport.

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