scholarly journals Association between components of metabolic syndrome with chronic kidney disease in Benin City, Nigeria

2018 ◽  
Vol 6 (5) ◽  
pp. 1655
Author(s):  
Oghenekaro G. Egbi ◽  
Evelyn I. Unuigbe ◽  
Efosa Oviasu
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diastolic Blood Pressure ◽  
Body Mass ◽  
Univariate Analysis ◽  
Spot Urine ◽  
Benin City ◽  
The Metabolic Syndrome

Background: The metabolic syndrome (MetS) is a constellation of risk factors of metabolic origin that promote the development of cardiovascular disease. More recently, an association with chronic kidney disease (CKD) is being reported. However, most of these studies are non-indigenous. The aim of the study was to determine the association between components of MetS and CKD in a Nigerian population.Methods: Patients with MetS were recruited from a tertiary hospital in Benin City, Nigeria. Blood pressures and body mass indices were measured. Plasma glucose, serum lipids, urea and creatinine and spot urine albumin: creatinine ratio were analyzed. CKD was defined as estimated glomerular filtration rate <60mls/min+ urinary ACR >30mg/g creatinine.Results: Obesity, waist/hip ratio, diastolic blood pressure, total cholesterol and LDL-cholesterol were associated with CKD in univariate analysis. Body mass index and diastolic blood pressure were independent predictors of CKD. There was a relationship between the number of MetS traits and CKD.Conclusions: CKD in patients with MetS may therefore result from a synergistic effect of components of the syndrome. Diastolic blood pressure and obesity may predict CKD in MetS patients. Early detection and treatment of obesity and hypertension may thus be a strategy to target the increasing prevalence of renal disease in MetS.

scholarly journals The Metabolic Syndrome and Risk of Chronic Kidney Disease: Pathophysiology and Intervention Strategies

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Heather A. LaGuardia ◽  
L. Lee Hamm ◽  
Jing Chen
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Intervention Strategies ◽  
Elevated Blood ◽  
The Metabolic Syndrome ◽  
Prevalence Of Obesity ◽  
Complications And Mortality

Metabolic syndrome is characterized by a clustering of cardiovascular risk factors, including abdominal obesity, elevated blood pressure and glucose concentrations, and dyslipidemia. The presence of this clinical entity is becoming more pervasive throughout the globe as the prevalence of obesity increases worldwide. Moreover, there is increased recognition of the complications and mortality related to this syndrome. This paper looks to examine the link between metabolic syndrome and the development of chronic kidney disease.

Systolic and Diastolic Blood Pressure Analysis in Each Etiology of Pra-Hemodialysis Chronic Kidney Disease

2015 ◽  
Vol 33 ◽  
pp. e41
Author(s):  
Ricardo Adrian Nugraha ◽  
Michael Jonatan ◽  
Pranawa Martosuwignjo ◽  
Sri Murtiwi
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Diastolic Blood Pressure ◽  
Pressure Analysis

The metabolic syndrome and chronic kidney disease

2006 ◽  
Vol 15 (4) ◽  
pp. 361-365 ◽  
Author(s):  
Carmen A Peralta ◽  
Manjula Kurella ◽  
Joan C Lo ◽  
Glenn M Chertow
Keyword(s):  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
The Metabolic Syndrome

Serum Markers of Low-Turnover Bone Disease in Mexican Children with Chronic Kidney Disease Undergoing Dialysis

2006 ◽  
Vol 26 (1) ◽  
pp. 78-84 ◽  
Author(s):  
Marcela Ávila-Díaz ◽  
Mario Matos ◽  
Elvia García-López ◽  
María-del-Carmen Prado ◽  
Florencia Castro-Vázquez ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Kidney Disease ◽  
Alkaline Phosphatase ◽  
Kidney Disease ◽  
Diastolic Blood Pressure ◽  
Serum Calcium ◽  
Bone Disease ◽  
Linear Growth ◽  
Serum Markers ◽  
Z Score

Background The frequency of low-turnover bone disease (LTBD) in patients with chronic kidney disease (CKD) has increased in past years. This change is important because LTBD is associated with bone pain, growth delay, and higher risk for bone fractures and extraosseous calcifications. LTBD is a histological diagnosis. However, serum markers such as parathyroid hormone (PTH) and calcium levels offer a noninvasive alternative for diagnosing these patients. Objective To describe the prevalence of LTBD in pediatric patients with renal failure undergoing some form of renal replacement therapy, using serum calcium and intact PTH levels as serum markers. Methods In this cross-sectional study, 41 children with CKD undergoing dialysis treatment (31 on continuous ambulatory peritoneal dialysis and 10 on hemodialysis) were included. There were no inclusion restrictions with respect to gender, cause of CKD, or dialysis modality. The children were studied as outpatients. The demographic data, CKD course, time on dialysis, phosphate-binding agents, and calcitriol prescription were registered, as well as weight, height, Z-score for height, linear growth rate, and Z-score for body mass index. Serum calcium, phosphorus, aluminum, PTH, alkaline phosphatase, osteocalcin, glucose, creatinine, urea, cholesterol, and triglycerides were measured. Results There were 20 (48.8%) children with both PTH <150 pg/mL and corrected total calcium >10 mg/dL who were classified as having LTBD[(+)]; the remaining 21 (51.2%) children were classified as having no LTBD[(–)]. The LTBD(+) patients were younger (11.2 ± 2.7 vs 13.2 ± 2.4 years, p < 0.01) but they had no differences regarding Z-scores for height. Linear growth in 6 months was less than expected in both groups (-0.15 ± 0.23 cm/month), but the difference between expected and observed growth was higher in the LTBD(+) group (-0.24 ± 0.14 vs –0.07 ± 0.28 cm/mo, p < 0.03). LTBD(+) patients also had lower serum creatinine (8.69± 2.75 vs 11.19 ± 3.17 mg/dL, p < 0.01), higher serum aluminum levels [median (range) 38.4 (9 – 106) vs 28.1 (9 – 62) μg/L, p < 0.05], and lower systolic blood pressure (112.0 ± 10.3 vs 125.0 ±12.9 mmHg, p < 0.015) and diastolic blood pressure (76.0 ± 9.7 vs 84.5 ± 8.2 mmHg, p < 0.017). A significant correlation was found between PTH and alkaline phosphatase ( r = 0.68, p < 0.001), but not between PTH and aluminum. Conclusion The LTBD(+) biochemical profile was found in 48.8% of the children and was associated with impaired linear growth. Aluminum contamination, evidenced by higher serum aluminum levels, may have had a pathogenic role in these disorders. Higher systolic and diastolic blood pressure levels may be related to higher serum PTH levels.

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