scholarly journals Correlation between glycemic control, lipid profile and C-reactive protein in adults with type 2 diabetes mellitus done in a tertiary care hospital of Nellore, Andhra Pradesh, India

2020 ◽  
Vol 7 (9) ◽  
pp. 1312
Author(s):  
Rajesh Kumar Meriga ◽  
Vishnu Anjan Nareddy ◽  
Sriram Venkata Sudha Sai Bhavya ◽  
Challa Sreekeerthi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Care Hospital ◽  
C Reactive Protein ◽  
Positive Correlation ◽  
Reactive Protein

Background: Diabetes mellitus refers to a group of common metabolic disorders that shares the phenotype of hyperglycemia. Complications of diabetes mellitus involve many organ systems only to play an important role in morbidity and mortality. Poor glycemic control is significantly associated with the development of macrovascular complications. Earlier studies have indicated that C-reactive protein (CRP) is an important risk factor for cardiovascular disease as evident from its higher levels in people with diabetes mellitus compared to those without. Not much is known whether CRP is related to the level of glycemic control. The purpose of this study is, to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus.Methods: Fifty patients with T2DM reporting to Narayana Medical College and Hospital were included in the study, in whom CRP levels were estimated by using commercially available kits and correlated with HbA1C and other risk factors of coronary artery disease. Follow-up was done on 20 patients who were not on statin therapy with repeat HbA1C and CRP.Results: This study showed that both HbA1C and CRP levels had reduced significantly in follow-up patients after putting them on treatment (p<0.05). It was also found that lower the HbA1C, lower was the CRP. A positive correlation was found between HbA1C and CRP (p<0.05).Conclusions: In this study of 50 patients with T2DM, it was found that CRP is significantly correlated with HbA1C level. A positive correlation was found between serum CRP and HbA1C in the initial group and in the follow-up patients, showing that CRP levels lowers with better glycemic control and correlates with dyslipidaemia profile.

scholarly journals Correlation between glycemic control markers and lipid profile in type 2 diabetes mellitus and impaired glucose tolerance

2018 ◽  
Vol 5 (4) ◽  
pp. 832
Author(s):  
Satish Basanagouda Biradar ◽  
Anasuya Sangaraj Desai ◽  
Sangappa Virupaxappa Kashinakunti ◽  
Manjula Rangappa ◽  
Gurupadappa Shantappa Kallaganad ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Lipid Profile ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Positive Correlation

Background: Many studies have compared and correlated glycemic control markers with lipid profile in type 2 diabetes mellitus (T2DM) patients, but very few studies correlate them in impaired glucose tolerance (IGT) individuals. Thus, the aim of this study was to find comparison and correlation between FBG, PPBG and HbA1c with lipid profile in T2DM patients and IGT individuals.Methods: The study was conducted at tertiary care hospital in north Karnataka. The diagnosis of T2DM and IGT was based on WHO criteria. 99 apparently healthy controls, 101 T2DM patients and 100 IGT subjects participated in the study.Results: All the biochemical parameters were significantly raised in IGT and T2DM patients as compared to controls.In T2DM, FBG showed significant positive correlation with TC (p=0.048) and significant negative correlation with HDL (p=0.000). PPBG and HbA1c showed significant positive correlation with TGL, TC VLDL and LDL and significant negative correlation with HDL, p value was 0.000 for all parameters. The correlation in IGT, FBG showed significant positive correlation with TC (p=0.000) and LDL (p=0.004), significant negative correlation with HDL (p=0.000). PPBG showed significant positive correlation with TGL, TC and VLDL and significant negative correlation with HDL(p=0.000).Conclusions: Diagnosis of T2DM, IGT and associated dyslipidema is necessary as life style modification and pharmacotherapy can control these situations and thereby reduce the cardiovascular risk.

scholarly journals C-reactive protein and glycemic control in adults with type 2 diabetes mellitus

2016 ◽  
Vol 2 ◽  
pp. 10-13
Author(s):  
Arun Sasidharan ◽  
Ajoy Krishnamurthy ◽  
Sida Tagore ◽  
Tejavathi Nagaraj ◽  
H. N. Santosh ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals STUDY TO DETERMINE THE RELATION BETWEEN HBA1C, LIPID PROFILE AND CRP IN INDIVIDUALS WITH TYPE 2 DIABETES MELLITUS IN A TERTIARY CARE HOSPITAL

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Shubham Bhaskar ◽  
Heena Anjum Tarafdar ◽  
Manish Kumar ◽  
SK Astik
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Significant Positive Correlation ◽  
Tertiary Care ◽  
Care Hospital ◽  
Positive Correlation ◽  
Significant Difference

Aim: The aim of this study to determine the relation between HbA1C, Lipid profile and CRP in individuals with type 2 diabetes mellitus. Material and methods: This prospective observational study was carried out in the Department of Medicine in Nalanda Medical College and Hospital at Patna, Bihar India for 1 year. The patients above 30 years with fasting venous blood glucose value equal or more than 100 mg/dl and postprandial glucose >140 mg/dl were include in this study. FBS and PPBS, CRP (immunoturbidimetric method), and HbA1C (ion exchange chromatography using HPLC) lipid profile samples were drawn at entry and at subsequent follow-up with a minimum gap of 3-6 months. Results: There was no significant difference between gender, age and BMI (p>0.05). FBS and HbA1C were directly correlated. PPBS showed a direct correlation with both HbA1C and CRP in this study. There was a significant positive correlation between CRP and total cholesterol (p<0.05). There was no significant correlation between CRP and LDL cholesterol (p>0.05). There was a negative correlation between HDL cholesterol and CRP. There was significant positive correlation between CRP and triglyceride levels (p<0.05). There was significant correlation between CRP and HbA1C (p<0.05). Conclusion: We concluded that the CRP is an additional marker of better glycaemic control and also correlates with the dyslipidaemia profile seen in type 2 diabetes mellitus. Keywords: C-reactive protein, Glycemic control, Hemoglobin A1C, Type 2 diabetes mellitus.

scholarly journals Association Between Cystatin C, Cystatin C Rangeability and Mortality of COVID-19 Patients With or Without Type 2 Diabetes Mellitus: An Opportunistic Retrospective Analysis

2020 ◽  
Author(s):  
Lei Yang ◽  
Dou Xu ◽  
Yiqing Tan ◽  
Bolin Li ◽  
Dan Zhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cystatin C ◽  
Clinical Manifestations ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Novel Coronavirus

Abstract Background: Since December of 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) exploded in Wuhan, and rapidly spread throughout China. Patients with COVID-19 demonstrated quite different appearances and outcomes in clinical manifestations. We aimed to figure out whether risk factors of the cystatin C (CysC) and the CysC rangeability are influencing the prognosis of COVID-19 patients with or without type 2 diabetes mellitus (T2DM).Methods: 675 T2DM patients and 602 non-T2DM patients were divided into low CysC group, high CysC group and low CysC rangeability group, high CysC rangeability group according to the serum CysC level and the change range of CysC. Demographic characteristics, clinical data and laboratory results of the four groups were collected and analyzed.Results: Our data showed that COVID-19 patients with high CysC level and CysC rangeability had more organic damage and higher mortality rate compared to those with low level or low rangeability of CysC. Furthermore, patients with higher CysC level and CysC rangeability also demonstrated higher blood lymphocytes (lymph), C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST) which may greatly influence disease progression and poor prognosis of COVID-19. After adjusting for possible confounders, multivariate analysis revealed that CysC≤0.93mg/dl as a reference, CysC＞0.93mg/dl were significantly associated with the risk of heart failure (OR=2.401, 95% CI: 1.118–5.156) and all-cause death (OR=2.734, 95% CI: 1.098-6.811); referring to CysC rangeability≤0, CysC rangeability＞0 significantly associated with all-cause death (OR=4.029, 95% CI: 1.864-8.706). Further grouped by T2DM, these associations were stronger in T2DM than in non-T2DM.Conclusions: It suggests that CysC level and CysC rangeability contribute to clinical manifestations and may influence the prognosis of COVID-19. The CysC is considered as a potential risk factor of the prognosis of COVID-19. Special medical care and appropriate intervention should be performed in COVID-19 patients with elevated CysC during hospitalization and later clinical follow-up, especially for those with T2DM.

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