Correlation of serum amylase level with the severity of acute organophosphorus compounds poisoning

Background: Organophosphorus (OP) poisoning is a common mode of suicidal poisoning in our country and is associated with significant mortality and morbidity. Serum amylase has shown a promising role in the assessment of the severity of OP poisoning. We conducted this study to see the association of serum amylase level with acute OP poisoning severity.Methods: This cross-sectional study was conducted among 150 patients admitted with acute OP poisoning to the inpatient department of medicine of a tertiary hospital in Bangladesh from July 2016 to June 2018. Peradeniya organophosphorus poisoning scale was used to detect clinical severity. Serum amylase was measured on the day of admission.Results: The patients' mean age was 23.68±6.80 years, and 65.3% were male. As assessed by the POP scale, 56.7%, 34.7%, and 8.7% of patients had mild, moderate, and severe grades of OP poisoning, respectively. The median serum amylase level was 103.50 (IQR 73.75-156.0) IU/l; 44.7% of the subjects had normal, and 53.3% had an elevated serum amylase. A progressive increase in serum amylase level was observed with the increasing severity of OP poisoning; 77.0 IU/l (IQR 58.0-97.0) in mild grade, 154.0 IU/l (IQR 125.25-162.5) in moderate grade, and 298.0 IU/l (IQR 289.5-305.0) in severe grade and the differences in the median amylase across the three groups were statistically significant (p<0.001). A significant positive correlation between serum amylase level and POP scale score (r=0.970; p<0.001) was also observed.Conclusions: Serum amylase level may be used as a readily available marker of the severity of acute OP poising in resource-poor settings.

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Impact of Serum Amylase Level in the Outcome of Acute Organophosphorus Poisoning: 2-Year Cross-Sectional Study at Rural Teaching Hospital

Journal of Laboratory Physicians ◽

10.1055/s-0041-1734015 ◽

2021 ◽

Author(s):

Aniket Patil ◽

Sunil Kumar ◽

Anil Inamdar ◽

Sourya Acharya ◽

Anil Wanjari ◽

...

Keyword(s):

Serum Amylase ◽

Organophosphorus Compounds ◽

Low Cost ◽

Cross Sectional Study ◽

P Value ◽

Amylase Level ◽

Sectional Study ◽

Cross Sectional ◽

Serum Amylase Level ◽

Organophosphorus Poisoning

Abstract Introduction Prompt recognition and aggressive management of acute intoxication due to organophosphorus poisoning are essential to minimize the morbidity and mortality. The present study was undertaken to know the prognosis and outcome of organophosphorus poisoning patients with the estimation of low-cost enzymes like the serum amylase level in a population with financial constraints. Method In this cross-sectional study, we had enrolled 100 cases that had a history of exposure to organophosphorus compounds, and the serum amylase level was measured in all the patients. We assessed the outcome of all the patients in the form of discharge, need of ventilators, intensive care unit stay, and death. Results The mean serum amylase level in discharge patients was 335.40 ± 192.45, and in the patients who died it was 843.37 ± 22.60. It was significant to predict the outcome (t-value 7.07, p-value 0.0001, statistically significant). Conclusion Serum amylase level shows significant correlation with clinical outcomes in organophosphorus poisoning.

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Abdominal pain and a raised amylase? It’s not always pancreatitis…

Acute Medicine Journal ◽

10.52964/amja.0310 ◽

2013 ◽

Vol 12 (3) ◽

pp. 163-165

Author(s):

IO Oluwatowoju ◽

◽

EO Abu ◽

G Lawson ◽

◽

...

Keyword(s):

Acute Pancreatitis ◽

Serum Amylase ◽

Epigastric Pain ◽

Elevated Serum ◽

High Serum ◽

Amylase Level ◽

Serum Amylase Level ◽

Heavy Alcohol ◽

Heavy Alcohol Consumption ◽

History Of

We report the case of a 72 year old man with a history of COPD and heavy alcohol consumption who was initially diagnosed with acute pancreatitis based on a presentation with epigastric pain and elevated serum amylase. Review of his notes revealed several previous similar admissions and extensive normal investigations apart from persistently elevated amylase. Further analysis showed evidence of macroamylasaemia which accounted for the apparently high serum amylase level.

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A Study of Correlation of Peradeniya Organophosphorus Scale (POP) and Serum Amylase Level in Assessing the Clinical Severity and Outcome of Organophosphorus Compound Poisoning

Journal of Medical Science And clinical Research ◽

10.18535/jmscr/v8i11.65 ◽

2020 ◽

Vol 08 (11) ◽

Author(s):

Dr Sindhu Malini. B ◽

Keyword(s):

Organophosphorus Compound ◽

Serum Amylase ◽

Clinical Severity ◽

Amylase Level ◽

Serum Amylase Level

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Clinical significance of serum amylase and glucose level in organophosphorus poisoning

Medical Journal of Pokhara Academy of Health Sciences ◽

10.3126/mjpahs.v2i3.26105 ◽

2019 ◽

Vol 2 (3) ◽

pp. 121-125

Author(s):

Manoj Koirala ◽

Bishow Raj Baral ◽

Buddhisagar Lamichanne

Keyword(s):

Acute Pancreatitis ◽

Glucose Level ◽

Serum Amylase ◽

Serum Glucose ◽

Clinical Severity ◽

Serum Glucose Level ◽

Amylase Level ◽

Serum Amylase Level ◽

Organophosphorus Poisoning ◽

The Mean

Background: Organophosphorous (OP) poisoning is a common problem in country like Nepal where agriculture is the backbone of the economy. The primary mechanism of action is inhibition of acetylcholinesterase (ACHE). Organophosphorus poisoning is a possible cause of acute pancreatitis along with alternation of glucose metabolism. Materials and Method: This was a hospital based cross-sectional comparative study. The level of serum amylase and glucose were measured in thirty-eight OP poisoned patients at the time of admission, before discharge and were compared. Results: Amongst 38 patients, Majority had mild OP poisoning 27(71.1%) as per Peradeniya Organophosphorus Poisoning (POP) score whereas 9(23.7%) had moderate and 2(5.2%) had severe poisoning. The mean initial serum amylase level in patients with mild poisoning was 152±73.92 (IU/L)(p=0.000), in moderate poisoning was 213.38±69.39 (IU/L) (p=0.223) and in severe poisoning was 171.33±107.22(IU/L) (p=0.259). There was increase in serum amylase level in all patients with poisoning but level did not increase in proportion to increase with severity of POP score. The mean initial serum glucose level in mild poisoning was 132.48±37.73 (Mg/dl) (p=0.024), in moderate poisoning was 139±44.59 (Mg/dl) (p=0.033) and in severe poisoning was 174±23.38 (Mg/dl) (p=0.22). The serum glucose level increased as the severity of POP score increased. The serum amylase and glucose levels in recovering patients showed a tendency to decrease to their normal values. No patient had developed acute symptomatic pancreatitis. Conclusion: Serum amylase and glucose level were increased in all patients with OP poisoning but didn’t correlate with the clinical severity. Routine measurement of serum amylase in patients of OP poisoning has little value in the absence of clinical acute pancreatitis.

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Electrolyte and other physiological abnormalities in patients with bulimia

Psychological Medicine ◽

10.1017/s0033291700050881 ◽

1983 ◽

Vol 13 (2) ◽

pp. 273-278 ◽

Cited By ~ 84

Author(s):

James E. Mitchell ◽

Richard L. Pyle ◽

Elke D. Eckert ◽

Dorothy Hatsukami ◽

Richard Lentz

Keyword(s):

Eating Disorder ◽

Metabolic Alkalosis ◽

Serum Amylase ◽

Elevated Serum ◽

Screening Tests ◽

Amylase Level ◽

Serum Electrolyte ◽

Serum Amylase Level ◽

Physiological Abnormalities ◽

Electrolyte Abnormalities

SYNOPSISThe frequencies of various forms of eating-related behaviour (such as vomiting and laxative abuse) are reported for a series of non-anorectic bulimia patients seen for evaluation in an eating disorders clinic. The results of serum electrolyte, glucose and other screening tests in these patients are presented. Electrolyte abnormalities were found in 82 of the 168 patients (48·8%) who were diagnosed as having either bulimia or atypical eating disorder. The most common abnormality was metabolic alkalosis (27·4%); hypochloremia (23·8%) and hypokalemia (13·7%) were also commonly seen. No significant blood sugar abnormalities were encountered. An elevated serum amylase level was found to be associated with frequent binge-eating and vomiting behaviour. The pathophysiology of electrolyte abnormalities in this patient group is briefly reviewed.

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ELEVATED SERUM AMYLASE LEVEL ASSOCIATED WITH RUPTURED ECTOPIC PREGNANCY

Journal of the American Medical Association ◽

10.1001/jama.1957.62980040006011a ◽

1957 ◽

Vol 164 (4) ◽

pp. 406 ◽

Cited By ~ 24

Author(s):

Maurice L. Kelley

Keyword(s):

Ectopic Pregnancy ◽

Serum Amylase ◽

Elevated Serum ◽

Amylase Level ◽

Serum Amylase Level

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Participants' Opinion about Conduct of Morbidity and Mortality Conferences in Surgical Practice in a Tertiary Hospital, Ethiopia

Ethiopian Journal of Health Sciences ◽

10.4314/ejhs.v30i3.6 ◽

2020 ◽

Vol 30 (3) ◽

Author(s):

Berhanetsehay Teklewold ◽

Tilahun Deresse ◽

Goytom Kinfe ◽

Henok Teshome

Keyword(s):

Patient Safety ◽

Multidisciplinary Team ◽

Addis Ababa ◽

Univariate Analysis ◽

Tertiary Hospital ◽

Morbidity And Mortality ◽

Cross Sectional ◽

Mortality And Morbidity ◽

Morbidity And Mortality Conferences

BACKGROUND: Morbidity and mortality conference has both educational and quality improvement purposes. However clear evidences for the effectiveness of the morbidity and mortality conferences in improving patient safety is lacking.METHODS: A facility based cross sectional study was conducted at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia, to assess participants’ opinion on benefits and functioning of morbidity and mortality conferences. Univariate analysis was used to determine the influence of professional type on participants’ opinion about the morbidity and mortality conferences.RESULT: A total of 98 participants completed the survey. The majority of the participants agreed that there was a structured system of case identification (67.3%), meeting format (72.4%), the conferences were conducted every month (79.6%), it is blame free (71.4%) and system of care was focus of discussion (70%). Most (88.8%) participants agreed that the conferences were important for improvement of patient safety and quality of care, whereas 67.3% of the participants believed that there is no written term of reference and prior dissemination of agendas. Only 40% agreed that there is multidisciplinary team involvement. Fifty one percent of them disagreed that there is a follow up on the implementation of the forwarded recommendations.CONCLUSION: Even though the majority of the participants were satisfied with the mortality and morbidity conferences, most disagreed on the presence of written term of reference, earlier dissemination of agendas, multidisciplinary team involvement and follow up on the implementation of the forwarded recommendations.

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Relationship between post-ERCP pancreatitis and the change of serum amylase level after the procedure

World Journal of Gastroenterology ◽

10.3748/wjg.v13.i28.3855 ◽

2007 ◽

Vol 13 (28) ◽

pp. 3855 ◽

Cited By ~ 17

Author(s):

Kei Ito

Keyword(s):

Serum Amylase ◽

Amylase Level ◽

Serum Amylase Level

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Arthralgia and Osteolytic Lesions Associated with Traumatic Pancreatitis in a 10-Year-Old Girl

International Journal of Pediatrics ◽

10.1155/2009/950687 ◽

2009 ◽

Vol 2009 ◽

pp. 1-3

Author(s):

Masayuki Obatake ◽

Yusuke Yamane ◽

Takayuki Tokunaga ◽

Yasuaki Taura ◽

Yukio Inamura ◽

...

Keyword(s):

Abdominal Pain ◽

Joint Pain ◽

Serum Amylase ◽

Knee Joints ◽

Pancreatic Pseudocysts ◽

Amylase Level ◽

Serum Amylase Level ◽

Osteolytic Lesions ◽

Pseudocyst Drainage ◽

Traumatic Pancreatitis

A case of traumatic pancreatitis with subsequent joint pain and osteolytic lesions is presented. A 10-year-old girl was admitted to our hospital with abdominal pain caused by blunt epigastric injury. She was diagnosed with traumatic pancreatitis, and multiple pancreatic pseudocysts subsequently developed. Two weeks after admission, she complained of joint pain, and MR revealed osteolytic lesions of both knee joints. On the 58th day, endoscopic transgastric pseudocyst drainage was performed. Joint pain and osteolytic lesions resolved rapidly, in parallel with the decrease in serum amylase level and pseudocyst size.

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