scholarly journals Hoarseness of voice – an institutional study

2016 ◽  
Vol 2 (4) ◽  
pp. 220 ◽  
Author(s):  
Manish Munjal ◽  
Bindia Ghera
Keyword(s):  
Vocal Cord ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Systemic Disease ◽  
Vocal Cord Palsy ◽  
Vocal Nodule ◽  
X Ray ◽  
Fibreoptic Laryngoscopy ◽  
Laryngopharyngeal Reflux Disease ◽  
Duration Of Disease

<p class="abstract"><strong>Background:</strong> Hoarseness is one of the earliest signal of local and systemic disease. It should be emphasized that hoarseness is not a disease in itself but a symptom of disease or disturbance of larynx or laryngeal innervation. The aim of the study was to analyse various causes and conditions associated with hoarseness of voice.</p><p class="abstract"><strong>Methods:</strong> We studied 150 patients in a prospective randomised study with inclusion criteria of hoarseness of voice, attending otolaryngology outpatient department of Dayanand medical college and hospital, Ludhiana, irrespective of their age, sex and duration of disease. No exclusion criteria were applied. All the routine investigations like Hb, BT, CT, TLC, DLC, urine-for albumin and sugar were carried out in all patients. X-ray chest- PA view and X-Ray soft tissue neck- AP and lateral view were done when required. Larynx was examined by flexible fibreoptic laryngoscopy followed by biopsy if suspicious looking area was seen. 4% lignocaine spray was used orally and nasally to provide local anaesthesia.</p><p class="abstract"><strong>Results:</strong> In the present study of 150 cases 87 were males and 63 were females with M:F ratio of 1.4:1 and age ranged from 10–90 years with majority of cases in 4th and 6th decade of their life. All patients had history of hoarseness of voice with most of patients having duration of disease between one month to one year. On flexible fibreoptic laryngoscopy 27% of cases showed normal study, vocal nodule was  most common, seen in 20% of cases, 10% showed vocal cord palsy and 10% had laryngopharyngeal reflux disease. Bilateral lesion (72.6%) predominated overall, with left sided (15.2%) of larynx affected more as compared to right side (12%).</p><p><strong>Conclusions:</strong> Flexible fibreoptic laryngoscopy is an effective alternative for diagnosis of laryngeal lesions and various causes of hoarseness of voice. Vocal nodule has been found as the commonest cause of hoarseness of voice followed by vocal cord palsy and laryngopharyngeal reflux disease. </p>

scholarly journals Laryngopharyngeal Reflux Disease: Diagnosis and Treatment in 2021

2021 ◽  
Vol 32 (2) ◽  
pp. 56-63
Author(s):  
Jeong Wook Kang ◽  
Young-Gyu Eun
Keyword(s):  
Vocal Cord ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Morphological Changes ◽  
Disease Diagnosis ◽  
Aerodigestive Tract ◽  
Diagnosis And Treatment ◽  
Upper Aerodigestive Tract ◽  
Laryngopharyngeal Reflux Disease ◽  
Questionnaire Method

Laryngopharyngeal reflux disease (LPRD) is an inflammatory condition of the upper aerodigestive tract mucosa induced by reflux content from stomach. Some of vocal cord diseases are associated with laryngopharyngeal reflux. Because of the pathophysiological features, proton pump inhibitor shows therapeutic effect on some vocal cord diseases. As like that, the gastric reflux contents can make macroscopic or microscopic morphological changes in the upper aerodigestive tract mucosa. Although the pathophysiology of LPRD is relatively clear, clinical diagnosis is still difficult. The diagnosis of LPRD includes objective tests such as 24-hours multichannel intraluminal impedance-pH metry and subjective tests such as questionnaire method. However, the objective verification of reflux is difficult due to invasiveness of the method, and the questionnaire methods have limitations because many symptoms are not specific for LPRD. Moreover, most methods are not fully standardized until now. Despite these limitations, many researchers are struggling to standardize diagnosis and treatment of LPRD, and there are several new achievements recently. Therefore, the purpose of this article is to review the recent literature on the clinical presentation, diagnosis, and treatment of LPRD, and to systematize our knowledge.

Optimal Regimen and Period for the Treatment of Patients with Laryngopharyngeal Reflux Disease

2014 ◽  
Vol 57 (10) ◽  
pp. 698 ◽  
Author(s):  
Yun Jae Lee ◽  
Min Kyu Kwak ◽  
Ji Hun Eom ◽  
Yong Bae Ji ◽  
Chang Myeon Song ◽  
...  
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease ◽  
Optimal Regimen

Influence of Helicobacter pylori Infection on Laryngopharyngeal Reflux Disease

2006 ◽  
Vol 57 (3) ◽  
pp. 268-272
Author(s):  
Ray Motohashi ◽  
Yusuke Watanabe ◽  
Ryoji Tokashiki ◽  
Kazuhiro Nakamura ◽  
Mamoru Suzuki
Keyword(s):  
Helicobacter Pylori ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Helicobacter Pylori Infection ◽  
Laryngopharyngeal Reflux Disease

Modified Reflux Scintigraphy Detects Pulmonary Microaspiration in Severe Gastro-Esophageal and Laryngopharyngeal Reflux Disease

Lung ◽  
2021 ◽  
Vol 199 (2) ◽  
pp. 139-145
Author(s):  
Jin-soo Park ◽  
Leticia Burton ◽  
Hans Van der Wall ◽  
Gregory Leighton Falk
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease

A Randomized Clinical Trial of Proton Pump Inhibitors Combined with Traditional Chinese Medicine in the Treatment of Laryngopharyngeal Reflux Disease

2021 ◽  
Author(s):  
Feng Pei ◽  
Wei Jia Hu ◽  
Yi Nan Mao ◽  
Yu Liang Zhao
Keyword(s):  
Proton Pump ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Short Form ◽  
Therapeutic Effects ◽  
Reflux Symptom Index ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Group A ◽  
Group B

Background:To explore whether combined with TCM based on classical proton pumpinhibitors PPIs therapy can achieve better efficacy for patients withlaryngopharyngeal reflux disease. Methods: There were 150 laryngopharyngeal refluxpatients enrolled and divided into three groups randomly, with 50 cases in each group.Patients in group A were treated with the proton pump inhibitor (PPI) lansoprazole.Patients in group B were treated with lansoprazole combined with Banxia Houpudecoction, and patients in group C were treated with acupuncture treatments and acombination of Chinese and Western medicine. The reflux symptom index (RSI), refluxfinding score (RFS), and quality of life (36 item short form health survey questionnaire)were assessed before and 4 and 8 weeks after treatment. Results: The RSI and RFSscores of the three groups were significantly reduced after treatment (P < 0.001). Ingroup B and C, they were lower than in group A at 8 weeks (P < 0.01). The SF 36 scoreof 3 groups increased after treatment. At both 4 and 8 weeks (P < 0.001), and patientsin groups B and C scored higher than patients in group A (P < 0.001). The total effectiverate of group B and group C was higher than that of group A (P < 0.05). Conclusion:All three treatments have therapeutic effects on the disease, but the efficacy of a PPIalone is not as good as the combined treatments’ efficacies. Moreover, PPI combinedwith Banxia Houpu decoction and/or acupuncture treatment substantially affects lifeimprovement.

Usefulness of Matrix Metalloproteinase-7 in Saliva as a Diagnostic Biomarker for Laryngopharyngeal Reflux Disease.

2021 ◽  
Author(s):  
Nu-Ri Im ◽  
Byoungjae Kim ◽  
Kwang-Yoon Jung ◽  
Seung-Kuk Baek
Keyword(s):  
Matrix Metalloproteinase ◽  
Sensitivity And Specificity ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Diagnostic Methods ◽  
Reflux Symptom Index ◽  
Enzyme Activity Assay ◽  
Symptom Index ◽  
Laryngopharyngeal Reflux Disease ◽  
Matrix Metalloproteinase 7

Abstract Introduction Several diagnostic methods are currently being used to diagnose LPRD (laryngopharyngeal reflux disease), but have the disadvantage of being invasive, subjective, or expensive. Objectives Our purpose in this study was to investigate the correlation between pepsin and MMP-7 (Matrix Metalloproteinase-7) in pharyngeal secretions of subjects according to RSI (Reflux Symptom Index) score to find out the diagnostic value of MMP-7. Method We recruited 173 subjects aged between 19 and 85 years who completed the RSI scale. All samples were taken after waking up, and the amount of the pepsin and MMP-7 in saliva were measured by means of an enzyme activity assay. Results There was a significant increase of pepsin and MMP-7 activity in the study group with an RSI score of 13 or higher. The sensitivity and specificity of MMP-7 for predicting the possibility of an RSI of 13 or more was higher than that of pepsin. When MMP-7 and pepsin were combined, this sensitivity and specificity increased. Conclusion An enzyme assay of MMP-7 in saliva may be a noninvasive and easy technique for diagnosing LPRD.

scholarly journals Laryngopharyngeal Reflux Disease - LPRD

2017 ◽  
Vol 71 (3) ◽  
pp. 215 ◽  
Author(s):  
Nizama Salihefendic ◽  
Muharem Zildzic ◽  
Emir Cabric
Keyword(s):  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Laryngopharyngeal Reflux Disease

scholarly journals SPECIFICS AND DIAGNOSTIC PROCEDURE IN REFLUX-RELATED DYSPHONIA

2020 ◽  
Vol 73 (4) ◽  
pp. 814-817
Author(s):  
Klaudia Sowa ◽  
Anna Łobaczuk-Sitnik ◽  
Bartosz Piszczatowski ◽  
Emilia Duchnowska ◽  
Bożena Kosztyła-Hojna ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Reflux Disease ◽  
Laryngopharyngeal Reflux ◽  
Morphological Changes ◽  
Voice Disorders ◽  
Vocal Folds ◽  
Congenital Defects ◽  
Upper Respiratory Tract ◽  
Laryngopharyngeal Reflux Disease ◽  
Pharynx Cancer

Voice is a work tool for many professional groups. Currently, cases of dysphonia of multiple origin consist a growing issue. Voice disorders may result from disturbed voice production process, congenital defects, post-traumatic conditions, chronic diseases or hormonal disorders. Chronic diseases causing voice disorders include laryngopharyngeal reflux disease and esophageal reflux disease. The chronic character of reflux causes the formation of numerous morphological changes of the larynx, including: hyperemia of the mucosa limited to arytenoid and intraarytenoid area, edema of the vocal folds, edema of the larynx mucosa. These changes contribute to voice disorders. Among the pathological changes of voice organ etiologically associated with reflux, the following disease units may be distinguished: reflux laryngitis, subglottic edema, contact ulceration, larynx granuloma, larynx and pharynx cancer. Many of disorders in the upper respiratory tract are etiologically related to reflux, e.g. dysphonia, grunting, coughing and dyspnoea.

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