scholarly journals Translational science in chronic tendinopathies

2021 ◽  
Vol 7 (3) ◽  
pp. 699
Author(s):  
Vijay J. Patel ◽  
Manish Khanna ◽  
Ketan K. Parmar
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Tendon Healing ◽  
Operative Management ◽  
Occupational Activity ◽  
Clinical Aspects ◽  
Complex Process ◽  
Medical Advance ◽  
Non Operative Management ◽  
Targeted Approach

<p>Chronic tendinopathies involve majority of patients in clinical practice of orthopaedic surgeons and sports physicians. Translational medicine confers an emerging medical advance efficiently towards the clinician directly from scientists which may be used as a targeted therapy. The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guideline. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.</p>

scholarly journals TRANSLATIONAL SCIENCE IN CHRONIC TENDINOPATHIES

2020 ◽  
pp. 1-4
Author(s):  
Vijay J Patel ◽  
Manish Khanna
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Treatment Protocol ◽  
Surgical Care ◽  
Occupational Activity ◽  
Future Research ◽  
Clinical Aspects ◽  
Physical Aspect ◽  
Clinical Implications ◽  
Translational Science

Introduction Chronic tendinopathies involves majority of patients in clinical practice of orthopaedic surgeons and sports physicians. The burdens of these problems to a society adversely effect the social, economical,occupational, recreational and physical aspect of patients. Translational medicine confers an emerging medical advances efficiently towards the clinician directly from scientists which may used as a targeted therapy. Objectives: The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. This fulfill the basic objectives of translational science to promote further medical and surgical care with ease. Methods We conducted search in electronic database of google scholar, pubmed ,Embase, web of science, Elsevier and science direct with reviews till October 2020. After obtaining search we narrowed our search for articles in terms of getting a literature specifically mentioned about translational medicine ,translational sciences, chronic tendinopathies. Methodological quality assessment and analysis were done in order to obtain relevantrepresenatation that best suited to our objectives for this article. As this is a narrative review we tried to accommodate important aspect of research and future directives for clinical implications as well as future research in the fields. Discussion: Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Current guidelines are lacking in agreement for any single guidelines for tendinopathies. Moreover, there aren’t any clearly defined ideal treatment protocol. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. Clinical implications of such emerging techniques and treatments where “bench to bedside” and “bedside to bench” motto of translational medicine should be fastened in order to achieve a newer approach. Conclusions: The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guidelines. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.

scholarly journals The management and outcome of paediatric splenic injuries in the Netherlands

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Maike Grootenhaar ◽  
Dominique Lamers ◽  
Karin Kamphuis-van Ulzen ◽  
Ivo de Blaauw ◽  
Edward C. Tan
Keyword(s):  
The Netherlands ◽  
Hospital Stay ◽  
Operative Management ◽  
Trauma Centre ◽  
Management Approach ◽  
Haemodynamic Instability ◽  
Low Grade ◽  
High Grade ◽  
Level 1 ◽  
Non Operative Management

Abstract Background Non-operative management (NOM) is generally accepted as a treatment method of traumatic paediatric splenic rupture. However, considerable variations in management exist. This study analyses local trends in aetiology and management of paediatric splenic injuries and evaluates the implementation of the guidelines proposed by the American Paediatric Surgical Association (APSA) in a level 1 trauma centre. Methods The charts of paediatric patients with blunt splenic injury (BSI) who were admitted or transferred to a level 1 trauma centre between 2003 and 2020 were retrospectively assessed. Information pertaining to demographics, mechanism of injury, injury description, associated injuries, intervention and outcomes were analysed and compared to international literature. Results There were 130 patients with BSI identified (63.1% male), with a mean age of 11.3 ± 4.0 and a mean Injury Severity Score (ISS) of 21.6 ± 13.7. Bicycle accidents were the most common trauma mechanism (23.1%). Sixty-four percent were multi-trauma patients, 25% received blood transfusions, and 31% were haemodynamically unstable. Mean injury grade was 3.0, with 30% of patients having a high-grade injury. In total, 75% of patients underwent NOM with a 100% efficacy rate. Total splenectomy rate was 6.2%. Four patients died due to brain damage. Patients with a high-grade BSI (grades IV–V) had a significantly higher ISS and longer bedrest and more often presented with an active blush on computed tomography (CT) scans than patients with a low-grade BSI (grades I–III). Non-operative management was mainly the choice of treatment in both groups (76.6% and 79.5%, respectively). Haemodynamic instability was a predictor for operative management (OM) (p = 0.001). Predictors for a longer length of stay (LOS) included concomitant injuries, haemodynamic instability and OM (all p < 0.02). Interobserver agreement in the grading of BSI is moderate, with a Cohens Kappa coefficient of 0.493. Conclusion Non-operative management has proven to be a realistic management approach in both low- and high-grade splenic injuries. Consideration for operative management should be based on haemodynamic instability. Compared to the anticipated length of bedrest and hospital stay outlined in the APSA guidelines, the Netherlands can reduce the length of bedrest and hospital stay through their non-operative management. Level of evidence Therapeutic study, level III

scholarly journals Non‐operative management of primary omental torsion, a case report and literature review

2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Mohammed S. Foula ◽  
Mohammed Sharroufna ◽  
Zahra H. Alshammasi ◽  
Omar S. Alothman ◽  
Bayan A. Almusailh ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Operative Management ◽  
Omental Torsion ◽  
Non Operative Management
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