scholarly journals TRANSLATIONAL SCIENCE IN CHRONIC TENDINOPATHIES

2020 ◽  
pp. 1-4
Author(s):  
Vijay J Patel ◽  
Manish Khanna
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Treatment Protocol ◽  
Surgical Care ◽  
Occupational Activity ◽  
Future Research ◽  
Clinical Aspects ◽  
Physical Aspect ◽  
Clinical Implications ◽  
Translational Science

Introduction Chronic tendinopathies involves majority of patients in clinical practice of orthopaedic surgeons and sports physicians. The burdens of these problems to a society adversely effect the social, economical,occupational, recreational and physical aspect of patients. Translational medicine confers an emerging medical advances efficiently towards the clinician directly from scientists which may used as a targeted therapy. Objectives: The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. This fulfill the basic objectives of translational science to promote further medical and surgical care with ease. Methods We conducted search in electronic database of google scholar, pubmed ,Embase, web of science, Elsevier and science direct with reviews till October 2020. After obtaining search we narrowed our search for articles in terms of getting a literature specifically mentioned about translational medicine ,translational sciences, chronic tendinopathies. Methodological quality assessment and analysis were done in order to obtain relevantrepresenatation that best suited to our objectives for this article. As this is a narrative review we tried to accommodate important aspect of research and future directives for clinical implications as well as future research in the fields. Discussion: Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Current guidelines are lacking in agreement for any single guidelines for tendinopathies. Moreover, there aren’t any clearly defined ideal treatment protocol. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. Clinical implications of such emerging techniques and treatments where “bench to bedside” and “bedside to bench” motto of translational medicine should be fastened in order to achieve a newer approach. Conclusions: The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guidelines. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.

scholarly journals Translational science in chronic tendinopathies

2021 ◽  
Vol 7 (3) ◽  
pp. 699
Author(s):  
Vijay J. Patel ◽  
Manish Khanna ◽  
Ketan K. Parmar
Keyword(s):  
Translational Research ◽  
Translational Medicine ◽  
Tendon Healing ◽  
Operative Management ◽  
Occupational Activity ◽  
Clinical Aspects ◽  
Complex Process ◽  
Medical Advance ◽  
Non Operative Management ◽  
Targeted Approach

<p>Chronic tendinopathies involve majority of patients in clinical practice of orthopaedic surgeons and sports physicians. Translational medicine confers an emerging medical advance efficiently towards the clinician directly from scientists which may be used as a targeted therapy. The main objective of translational research from “bench to bedside” is to test novel inventions in humans. Our purpose in this article to understand the translational medicine approach for chronic tendinopathies in clinical aspects. Translational research in chronic tendinopathies is required certainly due to plenty of reasons. Newer advances and targeted approach to these tendon disorders may curtail the further degenerative process. It aids in earlier diagnosis and prevention of morbidity, early occupancy of occupational activity, lack of economical as well as recreational failure. Pre-disease level activity is ultimate goal of any therapy. Tendon pathophysiology is constantly evolving researched topic in both biochemical as well as molecular aspect. The basic fundamental understanding of complex process of tendon healing and regeneration is necessary for formulating a newer guideline. The cornerstone of treatment of tendinopathies is still non-operative management. Physical therapy, better pain control, NSAIDS are still primary choice for these conditions. Various biological therapy whenever used one should combined them with other appropriate options to obtain an optimum outcome.</p>

The Importance of the Posterolateral Area of the Diaphragm Muscle for Palpation and for the Treatment of Manual Osteopathic Medicine

2021 ◽  
pp. 1-9
Author(s):  
Bruno Bordoni ◽  
Stevan Walkowski ◽  
Allan Escher ◽  
Bruno Ducoux
Keyword(s):  
Functional Anatomy ◽  
Diaphragm Muscle ◽  
Physiological Data ◽  
Future Research ◽  
Physical Aspect ◽  
Osteopathic Medicine ◽  
Self Healing ◽  
Hands On ◽  
Critical Issues ◽  
Solid Foundation

The eupneic act in healthy subjects involves a coordinated combination of functional anatomy and neurological activation. Neurologically, a central pattern generator, the components of which are distributed between the brainstem and the spinal cord, are hypothesized to drive the process and are modeled mathematically. A functionally anatomical approach is easier to understand although just as complex. Osteopathic manipulative treatment (OMT) is part of osteopathic medicine, which has many manual techniques to approach the human body, trying to improve the patient’s homeostatic response. The principle on which OMT is based is the stimulation of self-healing processes, researching the intrinsic physiological mechanisms of the person, taking into consideration not only the physical aspect, but also the emotional one and the context in which the patient lives. This article reviews how the diaphragm muscle moves, with a brief discussion on anatomy and the respiratory neural network. The goal is to highlight the critical issues of OMT on the correct positioning of the hands on the posterolateral area of the diaphragm around the diaphragm, trying to respect the existing scientific anatomical-physiological data, and laying a solid foundation for improving the data obtainable from future research. The correctness of the position of the operator’s hands in this area allows a more effective palpatory perception and, consequently, a probably more incisive result on the respiratory function.

scholarly journals Recent Advances in Nanotechnology with Nano-Phytochemicals: Molecular Mechanisms and Clinical Implications in Cancer Progression

2021 ◽  
Vol 22 (7) ◽  
pp. 3571
Author(s):  
Bonglee Kim ◽  
Ji-Eon Park ◽  
Eunji Im ◽  
Yongmin Cho ◽  
Jinjoo Lee ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Animal Studies ◽  
Molecular Mechanisms ◽  
Future Research ◽  
Clinical Implications ◽  
Research Perspectives ◽  
Current Review ◽  
Gold Silver ◽  
Significant Efficacy ◽  
Rapid Clearance

Biocompatible nanoparticles (NPs) containing polymers, lipids (liposomes and micelles), dendrimers, ferritin, carbon nanotubes, quantum dots, ceramic, magnetic materials, and gold/silver have contributed to imaging diagnosis and targeted cancer therapy. However, only some NP drugs, including Doxil® (liposome-encapsulated doxorubicin), Abraxane® (albumin-bound paclitaxel), and Oncaspar® (PEG-Asparaginase), have emerged on the pharmaceutical market to date. By contrast, several phytochemicals that were found to be effective in cultured cancer cells and animal studies have not shown significant efficacy in humans due to poor bioavailability and absorption, rapid clearance, resistance, and toxicity. Research to overcome these drawbacks by using phytochemical NPs remains in the early stages of clinical translation. Thus, in the current review, we discuss the progress in nanotechnology, research milestones, the molecular mechanisms of phytochemicals encapsulated in NPs, and clinical implications. Several challenges that must be overcome and future research perspectives are also described.

scholarly journals Measuring attachment and parental bonding in psychosis and its clinical implications

2014 ◽  
Vol 25 (2) ◽  
pp. 142-149 ◽  
Author(s):  
S. Mathews ◽  
J. Onwumere ◽  
S. Bissoli ◽  
M. Ruggeri ◽  
E. Kuipers ◽  
...  
Keyword(s):  
Attachment Theory ◽  
Attachment Style ◽  
Attachment Styles ◽  
Parental Bonding ◽  
Insecure Attachment ◽  
Self Report ◽  
Future Research ◽  
Clinical Implications ◽  
Term Outcome ◽  
Long Term Outcome

Background.Attachment theory proposes that psychological functioning and affect regulations are influenced by the attachment we form with others. Early relationships with parents or caregivers lay the foundations for attachment styles. These styles are proposed to influence how we relate to others during our life can be modified by the relationships and events we experience in our lifespan. A secure attachment style is associated with a capacity to manage distress, comfort with autonomy and the ability to form relationships with others, whereas insecure attachment can lead to dysfunctional relationships, emotional and behaviour avoidance. Attachment theory provides a useful framework to inform our understanding of relationship difficulties in people with psychosis. This paper aims to complement recent systematic reviews by providing an overview of attachment theory, its application to psychosis, including an understanding of measurement issues and the clinical implications offered.Method.A narrative review was completed of the measures of attachment and parental bonding in psychosis. Its clinical implications are also discussed. The paper also explores the link between insecure attachment styles and illness course, social functioning and symptomatology. The following questions are addressed: What are the key attachment measures that have been used within the attachment and psychosis literature? What are the results of studies that have measured attachment or parental bonding in psychosis and what clinical implications can we derive from it? What are some of the key questions for future research from these findings in relation to the onset of psychosis research field?Results.The most commonly used measures of attachment in psychosis research are reviewed. Self-report questionnaires and semi-structured interviews have mainly been used to examine attachment styles in adult samples and in recent years comprise a measure specifically developed for a psychosis group. The review suggests that insecure attachment styles are common in psychosis samples. Key relationships were observed between insecure, avoidant and anxious attachment styles and psychosis development, expression and long-term outcome.Conclusions.Attachment theory can provide a useful framework to facilitate our understanding of interpersonal difficulties in psychosis that may predate its onset and impact on observed variability in outcomes, including treatment engagement. Greater attention should be given to the assessment of attachment needs and to the development of interventions that seek to compensate for these difficulties. However, further investigations are required on specifying the exact mechanisms by which specific attachment styles impact on the development of psychosis and its course.

Mechanisms of Change in Dialectical Behaviour Therapy

2017 ◽  
pp. 514-532
Author(s):  
Tali Boritz ◽  
Richard J. Zeifman ◽  
Shelley F. McMain
Keyword(s):  
Attentional Control ◽  
Research Evidence ◽  
Coping Skills ◽  
Mechanisms Of Change ◽  
Future Research ◽  
Clinical Implications ◽  
Adaptive Coping ◽  
Behaviour Therapy ◽  
Dialectical Behaviour Therapy ◽  
Client Change

Research on processes and mechanisms of change aim to explain how and why an intervention leads to change. Despite some theoretical and empirical progress in understanding processes and mechanisms of change in Dialectical Behaviour Therapy (DBT), this remains an understudied area in the DBT literature. This chapter considers how DBT conceptualizes the etiology and maintenance of dysfunction, and how active ingredients in DBT treatment produce client change. It proposes four key mechanisms of change that have been a focus of scientific efforts in DBT research: (1) increased awareness and acceptance of emotion; (2) increased attentional control; (3) increased ability to modulate emotion; and (4) increased use of adaptive coping skills. Next, it reviews the research evidence to support these putative mechanisms of change. Finally, it discusses clinical implications of this research, and propose recommendations for future research on mechanisms of change in DBT.

scholarly journals All Families Are Special: Experiences of Lesbian-Parented Families

2018 ◽  
Vol 27 (1) ◽  
pp. 58-66 ◽  
Author(s):  
Rachel T. Gall ◽  
Lia Softas-Nall ◽  
Kiersten M. Eberle
Keyword(s):  
Elementary School ◽  
Young Children ◽  
Lived Experiences ◽  
Future Research ◽  
Clinical Implications ◽  
Lesbian Couples ◽  
Dialectical Tension

This study explores the lived experiences of members of lesbian-parented families incorporating a systemic perspective to include both the voices of mothers and their young children. Eight whole-family interviews were conducted with lesbian couples with at least one child in elementary school (aged 5–11). Six themes emerged from the study: intentionality in finding places to live and travel, having children, and having discussions with their children; views of themselves as advocates and being “out” in their communities; noticing how times are changing; identifying assumptions as a two-way street; perceptions of gender surrounding parenting and the salience of various identities; and the dialectical tension between wanting to be perceived as normal and wanting to acknowledge their uniqueness. Clinical implications and suggestions for future research are discussed.

The Neuropsychology of Movement and Movement Disorders: Neuroanatomical and Cognitive Considerations

2017 ◽  
Vol 23 (9-10) ◽  
pp. 768-777 ◽  
Author(s):  
Kathleen Y. Haaland ◽  
Richard P. Dum ◽  
Pratik K. Mutha ◽  
Peter L. Strick ◽  
Alexander I. Tröster
Keyword(s):  
Motor System ◽  
Movement Control ◽  
Neural Circuitry ◽  
Future Research ◽  
Clinical Implications ◽  
Hemispheric Differences ◽  
Healthy Individuals ◽  
The Past ◽  
Cognitive Influences ◽  
Parallel Circuits

AbstractThis paper highlights major developments over the past two to three decades in the neuropsychology of movement and its disorders. We focus on studies in healthy individuals and patients, which have identified cognitive contributions to movement control and animal work that has delineated the neural circuitry that makes these interactions possible. We cover advances in three major areas: (1) the neuroanatomical aspects of the “motor” system with an emphasis on multiple parallel circuits that include cortical, corticostriate, and corticocerebellar connections; (2) behavioral paradigms that have enabled an appreciation of the cognitive influences on the preparation and execution of movement; and (3) hemispheric differences (exemplified by limb praxis, motor sequencing, and motor learning). Finally, we discuss the clinical implications of this work, and make suggestions for future research in this area. (JINS, 2017, 23, 768–777)

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