Clinico-Etiological study of benign lesions of pinna and its management

SummaryAim: To evaluate the diagnostic value (sensitivity, specificity) of positron emission mammography (PEM) in a single site non-interventional study using the maximum PEM uptake value (PUVmax). Patients, methods: In a singlesite, non-interventional study, 108 patients (107 women, 1 man) with a total of 151 suspected lesions were scanned with a PEM Flex Solo II (Naviscan) at 90 min p.i. with 3.5 MBq 18F-FDG per kg of body weight. In this ROI(region of interest)-based analysis, maximum PEM uptake value (PUV) was determined in lesions, tumours (PUVmaxtumour), benign lesions (PUVmaxnormal breast) and also in healthy tissues on the contralateral side (PUVmaxcontralateral breast). These values were compared and contrasted. In addition, the ratios of PUVmaxtumour / PUVmaxcontralateral breast and PUVmaxnormal breast / PUVmaxcontralateral breast were compared. The image data were interpreted independently by two experienced nuclear medicine physicians and compared with histology in cases of suspected carcinoma. Results: Based on a criteria of PUV>1.9, 31 out of 151 lesions in the patient cohort were found to be malignant (21%). A mean PUVmaxtumour of 3.78 ± 2.47 was identified in malignant tumours, while a mean PUVmaxnormal breast of 1.17 ± 0.37 was reported in the glandular tissue of the healthy breast, with the difference being statistically significant (p < 0.001). Similarly, the mean ratio between tumour and healthy glandular tissue in breast cancer patients (3.15 ± 1.58) was found to be significantly higher than the ratio for benign lesions (1.17 ± 0.41, p < 0.001). Conclusion: PEM is capable of differentiating breast tumours from benign lesions with 100% sensitivity along with a high specificity of 96%, when a threshold of PUVmax >1.9 is applied.

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Significance of 18F-fluorocholine PET/CT positive pulmonary lesions in prostate cancer patients

Nuklearmedizin ◽

10.3413/nukmed-0737-15-04 ◽

2015 ◽

Vol 54 (05) ◽

pp. 211-216 ◽

Cited By ~ 3

Author(s):

A. Baskin ◽

G. Amzalag ◽

F. Buchegger ◽

R. Miralbell ◽

O. Ratib ◽

...

Keyword(s):

Prostate Cancer ◽

Primary Lung Cancer ◽

Final Diagnosis ◽

Papillary Adenocarcinoma ◽

Bronchioloalveolar Carcinoma ◽

Maximum Diameter ◽

Benign Lesions ◽

Pulmonary Carcinoid ◽

Pulmonary Lesions ◽

Pet Ct

SummaryAim: To assess the frequency and the significance of incidental pulmonary lesions with 18F-fluorocholine (18F-FCH) PET/CT in prostate cancer (PCa) patients. Patients, methods: 225 consecutive PCa patients referred for 18F-FCH PET/CT (median age 68 years) were retrospectively evaluated for the presence of lesions in the lungs: 173 referred for restaging and 52 for initial staging regarding their high risk of extra prostatic extension. The final diagnosis was based on histopathological or on clinical and radiological follow-up. Results: 13 patients had 18F-FCH positive pulmonary and 8 patients malignant lesions: 5 patients (38%) had a primary lung cancer (2 squamous cell carcinomas, 1 papillary adenocarcinoma, 1 typical pulmonary carcinoid, 1 bronchioloalveolar carcinoma) and 3 patients (23%) PCa metastases. Benign lesions were found in 5 subjects (38%). SUVmax and maximum diameter were neither significantly different in primary and metastatic tumors nor between malignant and benign lesions. Conclusions: Although our results suggest that incidental uptake in the lungs in PCa patients are nonspecific, their detection may have a significant impact on patient management knowing that more than 60% represent malignant diseas.

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Endoscopic nasal lateral wall dissection approach for benign lesions of maxillary sinus

Academic Journal of Second Military Medical University ◽

10.3724/sp.j.1008.2009.00561 ◽

2009 ◽

Vol 29 (5) ◽

pp. 561-564

Author(s):

Li-yun YING ◽

Chang-qing ZHAO

Keyword(s):

Maxillary Sinus ◽

Lateral Wall ◽

Benign Lesions

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Exfoliative Dermatitis: A Clinico-etiological Study

International Archives of BioMedical and Clinical Research ◽

10.21276/iabcr.2017.3.1.17 ◽

2017 ◽

Vol 3 (1) ◽

Author(s):

Tapan Kumar Dhali ◽

Mohammad Asad Haroon

Keyword(s):

Exfoliative Dermatitis ◽

Etiological Study

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Shared and unique metabolic features of the malignant and benign thyroid lesions determined with use of 1H HR MAS NMR spectroscopy

Scientific Reports ◽

10.1038/s41598-020-79565-8 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Agnieszka Skorupa ◽

Mateusz Ciszek ◽

Ewa Chmielik ◽

Łukasz Boguszewicz ◽

Małgorzata Oczko-Wojciechowska ◽

...

Keyword(s):

Nmr Spectra ◽

Univariate Analysis ◽

Mas Nmr ◽

Metabolic Reprogramming ◽

Benign Lesions ◽

Chronic Thyroiditis ◽

Malignant Lesions ◽

Metabolic Heterogeneity ◽

Benign Thyroid ◽

Thyroid Lesions

AbstractThe purpose of this work was to investigate the distinct and common metabolic features of the malignant and benign thyroid lesions in reference to the non-transformed tissue from the contralateral gland (chronic thyroiditis and colloid goiter). 1H HR MAS NMR spectra of 38 malignant lesions, 32 benign lesions and 112 samples from the non-tumoral tissue (32 from chronic thyroiditis and 80 samples from colloid goiter) were subjected both to multivariate and univariate analysis. The increased succinate, glutamine, glutathione, serine/cysteine, ascorbate, lactate, taurine, threonine, glycine, phosphocholine/glycerophosphocholine and decreased lipids were found in both lesion types in comparison to either colloid goiter or chronic thyroiditis. The elevated glutamate and choline, and reduced citrate and glucose were additionally evident in these lesions in reference to goiter, while the increased myo-inositol—in comparison to thyroiditis. The malignant lesions were characterized by the higher alanine and lysine levels than colloid goiter and thyroiditis, while scyllo-inositol was uniquely increased in the benign lesions (not in cancer) in comparison to both non-tumoral tissue types. Moreover, the benign lesions presented with the unique increase of choline in reference to thyroiditis (not observed in the cancerous tissue). The metabolic heterogeneity of the non-tumoral tissue should be considered in the analysis of metabolic reprogramming in the thyroid lesions.

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Potential Effects of Human Papillomavirus Type Substitution, Superinfection Exclusion and Latency on the Efficacy of the Current L1 Prophylactic Vaccines

Viruses ◽

10.3390/v13010022 ◽

2020 ◽

Vol 13 (1) ◽

pp. 22

Author(s):

Ian N. Hampson ◽

Anthony W. Oliver ◽

Lynne Hampson

Keyword(s):

Life Cycle ◽

High Risk ◽

Outcome Data ◽

Benign Lesions ◽

Complex Dynamic ◽

Papilloma Virus ◽

Superinfection Exclusion ◽

Different Types ◽

Hpv Types ◽

Type Substitution

There are >200 different types of human papilloma virus (HPV) of which >51 infect genital epithelium, with ~14 of these classed as high-risk being more commonly associated with cervical cancer. During development of the disease, high-risk types have an increased tendency to develop a truncated non-replicative life cycle, whereas low-risk, non-cancer-associated HPV types are either asymptomatic or cause benign lesions completing their full replicative life cycle. HPVs can also be present as non-replicative so-called “latent” infections and they can also show superinfection exclusion, where cells with pre-existing infections with one type cannot be infected with a different HPV type. Thus, the HPV repertoire and replication status present in an individual can form a complex dynamic meta-community which changes with respect to both time and exposure to different HPV types. In light of these considerations, it is not clear how current prophylactic HPV vaccines will affect this system and the potential for iatrogenic outcomes is discussed in light of recent outcome data.

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