scholarly journals Characteristics of granulosa cell tumor at Dr. Soetomo general hospital from 2014 to 2019

2021 ◽  
Vol 8 (4) ◽  
pp. 585-591
Author(s):  
Brahmana Askandar Tjokroprawiro ◽  
Eko Santoso ◽  
Ni Nyoman Ratih Pradnyani
Keyword(s):  
Granulosa Cell ◽  
Early Stage ◽  
Granulosa Cell Tumor ◽  
Figo Stage ◽  
Cell Tumor ◽  
Rank Test ◽  
Fisher Exact Test ◽  
Recurrence Rates ◽  
Early Stage Disease

The aim of the present study was to investigate tumor characteristics, treatment, recurrence, and prognosis in both Granulosa Cell Tumor types.A retrospective review study of 38 patients in a single institute; We identified patients with GCTs diagnosed between 2014 and 2019 in the Regional General Dr. Soetomo Hospital. Surgical outcome, pathological findings and follow-up data were analyzed. Statistical analyses were conducted using Fisher exact test and Kaplan-Meier survival curves and compared with the log-rank test. The prevalence of AGCT subtypes as the most common type occurring in 97% of cases. The median age at diagnosis among patients with AGCT is 47.5 years (range 41-59), and most women are premenopausal and multiparous. In our literature review Stage 1 disease is 76% with Overall Survival (OS) for 5years is 89.7%. FIGO stage and adjuvant therapy was not shown a positive correlation with recurrency (p >0.05). Rate of recurrence in AGCT is reported to be as high as 5.26%.GCT is a rare low malignant tumor, majority of patients present with early-stage disease and generally have a favorable prognosis. Stage is not considered as the most important prognostic factor. The role of adjuvant chemotherapy treatment is debatable as it was not shown to reduce recurrence rates. Long-term surveillance including routine clinical follow-up and tumor markers serial evaluation is mandatory to evaluate recurrency.

Prognostic Factors in Adult Granulosa Cell Tumor: A Long Follow-Up at a Single Center

2016 ◽  
Vol 26 (4) ◽  
pp. 619-625 ◽  
Author(s):  
Alper Karalok ◽  
Taner Turan ◽  
Isin Ureyen ◽  
Tolga Tasci ◽  
Derman Basaran ◽  
...  
Keyword(s):  
Lymph Node ◽  
Granulosa Cell ◽  
Gynecologic Oncology ◽  
Menopausal Status ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Recurrence Rates ◽  
Staging Surgery ◽  
Cyst Rupture

ObjectiveIn this study, we aimed to demonstrate characteristics, recurrence rates, survival numbers, and factors associated with survival of patients with adult granulosa cell tumor (AGCT) from a single institution. Our secondary goal was to evaluate the necessity of staging surgery and the importance of a comprehensive lymphadenectomy in these patients.MethodsThe data of 158 patients in our institution who were diagnosed with AGCT between 1988 and 2013 were evaluated. The data were obtained from the files of the patients, electronic database of the gynecologic oncology clinic, operation notes, and pathology records.ResultsThe median (range) age of the patients was 50.3 (22–82) years. The main symptom was postmenopausal bleeding (25.9%). Seventy-six percent of the patients underwent staging surgery including lymphadenectomy. Among these patients, 3 (2.5%) had lymph node metastasis. The median (range) follow-up time was 97 (1–296) months. In the follow-up period, 18 patients (12.5%) had recurrence. Menopausal status (P = 0.016), advanced age (P = 0.024), cyst rupture (P = 0.001), poorly differentiated tumor (P = 0.002), and advanced stage (P < 0.001) were associated with recurrence. Stage was the only independent prognostic factor for the development of recurrence. None of the patients had lymph node failure.ConclusionsIn the present study with a long follow-up period and in which most of the patients had staging surgery including lymphadenectomy (76.6%), lymph node recurrence was not observed and the total recurrence rate (12.5%) was lower than that reported in the literature. The study showed the importance of surgical staging in patients with AGCT.

scholarly journals Juvenile granulosa cell tumor

2016 ◽  
Author(s):  
Geetanjali Tuteja ◽  
S. Unmesh ◽  
S. Shree ◽  
S. Rudra ◽  
Keyword(s):  
Granulosa Cell ◽  
Precocious Puberty ◽  
Early Stage ◽  
Pubertal Development ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Tumour Resection ◽  
Granulosa Cell Tumour ◽  
Juvenile Granulosa Cell Tumor

The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumour of the ovary–and a brief literature review. A one year-old baby girl presented with mass abdomen, vaginal discharge and rapid onset of pubertal development. She underwent an exploratory laparotomy for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

Granulosa Cell Tumor of the Ovary

2003 ◽  
Vol 21 (6) ◽  
pp. 1180-1189 ◽  
Author(s):  
Susan Tinsley Schumer ◽  
Stephen A. Cannistra
Keyword(s):  
High Risk ◽  
Granulosa Cell ◽  
Prolonged Exposure ◽  
Uterine Cancer ◽  
High Risk Patient ◽  
Disease Free Survival ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Childbearing Age ◽  
Early Stage Disease

Adult granulosa cell tumor (GCT) of the ovary is oftentimes a hormonally active, stromal cell neoplasm that is distinguished by its ability to secrete sex steroids such as estrogen. Patients may present with vaginal bleeding caused by endometrial hyperplasia or uterine cancer as a result of prolonged exposure to tumor-derived estrogen. In addition, GCT is a vascular tumor that may occasionally rupture and result in abdominal pain, hemoperitoneum, and hypotension, mimicking an ectopic pregnancy in younger patients. GCT is usually associated with a mass on pelvic examination that is subsequently confirmed on ultrasonography. Surgery is required for definitive tissue diagnosis, staging, and tumor debulking. In older women, a total abdominal hysterectomy and bilateral salpingooophorectomy are typically performed. In women of childbearing age, a more conservative unilateral salpingo-oophorectomy may be performed, assuming that careful staging reveals that the disease has not extended outside of the involved ovary and that a concomitant uterine cancer has been excluded. Survival of patients with GCT is generally excellent because most patients present with early-stage disease, although certain high-risk patient groups may be identified. Stage is the most important prognostic factor, with a higher risk of relapse being associated with stages II through IV disease. In addition, patients with stage I disease associated with features such as large tumor size, high mitotic index, or tumor rupture may also be at higher risk in some series. The value of postoperative adjuvant therapy for high-risk patients has not been investigated by prospective randomized trials, which are difficult to perform because of the rarity of this tumor. Nonetheless, the use of adjuvant chemotherapy or radiation has sometimes been associated with prolonged disease-free survival in patients with high-risk features. Because of the propensity of GCT to recur years after initial diagnosis, prolonged surveillance with serial physical examination and serum tumor markers such as estradiol and inhibin is reasonable.

Adult Granulosa Cell Tumor of the Ovary: A Clinico Pathologic Study of 35 Cases

1998 ◽  
Vol 84 (1) ◽  
pp. 60-64 ◽  
Author(s):  
Rosanna Fontanelli ◽  
Bernardina Stefanon ◽  
Francesco Raspagliesi ◽  
Rado Kenda ◽  
Gorana Tomasic ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Disease Free Survival ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Progression Rate ◽  
Free Survival ◽  
Tumor Involvement ◽  
Disease Free Survival Rate ◽  
Disease Free

Aims and background Adult granulosa cell tumor has a low malignant potential but requires an extensive follow-up of more than 5 years to accurately assess tumor activity. The aim of the present study was to evaluate the clinical characteristics, the treatment and the outcome of this rare ovarian tumor. Study design A retrospective review of 35 cases treated at primary onset of disease during a 23-year period from 1971 to 1993. Results The disease-free survival rate for stages IA-B-C at 5 and 10 years was 90% and 84%, respectively; for stages III-IV the 5-year freedom from progression rate was 16%. Conclusions The most important prognostic factor appears to be the extent of tumor involvement outside of the ovary.

scholarly journals Granulosa Cell Tumor Of The Ovary – An Incidental Finding During Caesarean Section – A Rare Case Report

2015 ◽  
Vol 12 (1) ◽  
pp. 60-63
Author(s):  
J Roy ◽  
AS Babu
Keyword(s):  
Caesarean Section ◽  
Granulosa Cell ◽  
Incidental Finding ◽  
Treatment Plan ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Teratoma ◽  
Borderline Tumor ◽  
Rare Case Report

Approximately one-fourth of the ovarian neoplasms and cysts are diagnosed incidentally during caesarean section. The possibility of borderline tumor or cancer should be considered although existence of ovarian malignancy in pregnancy is rare. We report a case of a rare solid malignant tumor of the ovary incidentally found during caesarean section. Intraoperatively, it was thought to be a variant of the common ovarian teratoma. Ovariectomy was done but histopathology revealed it to be granulosa cell tumor. The diagnosis changed the prognosis and future treatment plan drastically. Equipped with this knowledge physicians can be made aware of the existence of this little-known ovarian neoplasm along with its rare association with pregnancy. Also one can better manage, counsel and follow-up the patients after delivery, given the knowledge of the tumours’ inevitable malignant potential and its high incidence of recurrence.Kathmandu University Medical Journal Vol.12(1) 2014: 60-63

scholarly journals Juvenile granulosa cell tumor

2016 ◽  
Author(s):  
Geetanjali Tuteja ◽  
S. Unmesh ◽  
S. Shree ◽  
S. Rudra ◽  
Keyword(s):  
Granulosa Cell ◽  
Precocious Puberty ◽  
Early Stage ◽  
Pubertal Development ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Cell Tumour ◽  
Tumour Resection ◽  
Granulosa Cell Tumour ◽  
Juvenile Granulosa Cell Tumor

The differential diagnosis for precocious puberty in a young female includes peripheral causes. This case report documents a rare cause of isosexual precocious puberty, a juvenile granulosa cell tumour of the ovary–and a brief literature review. A one year-old baby girl presented with mass abdomen, vaginal discharge and rapid onset of pubertal development. She underwent an exploratory laparotomy for tumour resection. Pathology reported a juvenile granulosa cell tumour of the ovary. Early stage granulosa cell tumor surgically treated has good prognosis. Adjuvant chemotherapy is not indicated in this setting.

Outcomes of fertility-sparing surgery in ovarian juvenile granulosa cell tumor

2019 ◽  
Vol 29 (4) ◽  
pp. 787-791 ◽  
Author(s):  
Dan Zhao ◽  
Yan Song ◽  
Yanan Zhang ◽  
Bin Li
Keyword(s):  
Granulosa Cell ◽  
Disease Onset ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Fertility Sparing Surgery ◽  
Juvenile Granulosa Cell Tumor ◽  
Fertility Sparing ◽  
Mean Size ◽  
The Mean

ObjectiveTo analyze the clinical characteristics, diagnosis, and treatment of ovarian juvenile granulosa cell tumor.MethodsThe clinical and pathological data of six patients with ovarian juvenile granulosa cell tumor was collected.ResultsThe mean age of disease onset was 20.5 years (range 12 to 33). All six patients had an adnexal mass located laterally in the pelvis, and two developed ascites. All patients had fertility-sparing surgery with complete staging. The mean size of the tumors was 15.3 cm (range 5 to 35). Ovarian sex cord stromal tumors were diagnosed or highly suspected from the frozen sections for all patients. Five patients received three to six courses of postoperative adjuvant chemotherapy, with three receiving a bleomycin/etoposide/cisplatin regimen and two receiving a paclitaxel/carboplatin regimen. The five stage I patients had no recurrence with 52 to 155 months of follow-up. The patient with stage IIIB disease had a recurrence 55 months’ later and underwent reoperation and chemotherapy. This patient remained disease-free 30 months after the reoperation.ConclusionsFertility-sparing surgery is the treatment of choice for ovarian juvenile granulosa cell tumor and the overall prognosis is good.

scholarly journals Ultrasound feature discordance in a bilateral juvenile ovarian granulosa cell tumor: A case report

2021 ◽  
Author(s):  
Li Zhang ◽  
Sheng Cai ◽  
Yahong Wang ◽  
Ying Wang ◽  
Zhitong Ge ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Granulosa Cell Tumor ◽  
Exploratory Laparotomy ◽  
Cell Tumor ◽  
Cystic Lesions ◽  
Ovarian Granulosa Cell ◽  
Ovarian Granulosa Cell Tumor ◽  
The Right ◽  
Cystic Masses

Abstract BackgroundAs a rare ovarian stromal tumor, the juvenile ovarian granulosa cell tumor (JGCT) is mainly seen in premenstrual and young women. It associates with high malignancy and recurrence rate, and early diagnosis and treatment could improve prognosis. Most cases are unilateral solid-cystic or solid masses, while unilocular cystic masses are rarely seen. As cystic ovarian tumors are often misdiagnosed as benign cystic lesions or functional cysts, cystic JGCT should not be overlooked.Case presentationWe report this special case of a 10-year-old female patient. It’s the first reported JGCT with completely inconsistent bilateral imaging manifestations, including an extremely rare unilocular cystic JGCT. A large solid-cystic JGCT appeared in her left ovary, and left adnexal resection was performed. A unilocular cyst occurred in the right ovary two years later. It was with a regular shape and smooth inner wall, mimicking a benign cyst. Since the patient was young and had the desire to preserve the right ovary, follow-up was initially recommended. However, the cyst size increased rapidly and exploratory laparotomy was finally performed. Pathology showed a unilocular cystic JGCT.ConclusionsAs cystic masses in young patients are easily misdiagnosed as benign or physiologic lesions, this case emphasizes the importance of postoperative follow-up for JGCTs. Exploratory laparotomy of persistent cystic lesions should be considered when necessary.

scholarly journals Granulosa cell tumor of the ovary: a clinicopathological study of six cases

1970 ◽  
Vol 1 (2) ◽  
pp. 96-99 ◽  
Author(s):  
RC Adhikari ◽  
A Jha ◽  
G Shayami
Keyword(s):  
Granulosa Cell ◽  
Teaching Hospital ◽  
Tumor Size ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
University Teaching ◽  
Malignant Neoplasms ◽  
Patient Profile ◽  
Granulosa Cell Tumors

Background: Ovarian granulosa cell tumors are rare malignant neoplasms that originate from the sexcord stromal cells of the ovary. The study aims to collate data of all granulosa cell tumors diagnosed in Tribhuvan University Teaching Hospital over the last 3 years and to describe the incidence, patient profile, ultrasonographic and histopathologic findings in our local context. Materials and Methods: A total of 6 (5%) granulosa cell tumors, diagnosed in Tribhuvan University Teaching Hospital during the period from April 2008 to March 2011. The patient’s age, symptoms, radiological findings, type of surgery performed, tumor size and follow-up status were evaluated. Results: All 6 patients were diagnosed as adult granulosa cell tumor, three of which were postmenopausal (50%) and remaining there was premenopausal. The symptoms recorded were uterine bleeding, abdominal pain, distention and mass. Grossly, in 3 cases granulosa cell tumors were solid and firm, in 2 cases solid and cystic and 1 case is predominantly cystic. Histologically, variety of patterns including diffuse, trabecular, cords, tubular, nesting and Call-Exner bodies were found. Nuclear grooves were observed in all cases. Follow up on 2 patients revealed no evidence of recurrence. Conclusion: This study supports the view that most granulosa cell tumors are diagnosed in stage I and there is good correlation between radiological and gross findings in terms of tumor size and solid or cystic status. Keywords: Granulosa cell tumor; Ovary; Histopathological findings DOI: http://dx.doi.org/10.3126/jpn.v1i2.5400 JPN 2011; 1(2): 96-99

scholarly journals Case series of rare ovarian malignancy: granulosa cell tumor

2017 ◽  
Vol 5 (2) ◽  
pp. 723 ◽  
Author(s):  
Kavitha Yogini Duraisamy ◽  
Devi Balasubramaniam ◽  
Palanivelu Chinnusamy ◽  
Rashmi Barnwal
Keyword(s):  
Granulosa Cell ◽  
Early Stage ◽  
Frozen Section ◽  
Young Patients ◽  
Case Series ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Future Fertility ◽  
Fertility Sparing ◽  
Sex Cord Stromal Tumors

Granulosa cell tumors are rare ovarian sex cord stromal tumors characterized by indolent course and favorable prognosis. The treatment of granulosa cell tumor is individualized based on many factors like age, desire for future fertility and stage of the disease. Here, we report three cases out of which two were acute presentation and one was diagnosed incidentally when she got evaluated for menstrual irregularity. Fertility sparing surgery with proper staging is offered to young patients presenting in early stage. In patients who have completed family, comprehensive surgical staging including hysterectomy with bilateral salpingo oophorectomy is the standard treatment. Lymph node metastasis in granulosa cell tumor is very rare, hence pelvic and para aortic lymphadenectomy can be safely avoided if preoperative findings and frozen section favour granulosa cell tumor.

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