scholarly journals Local drug delivery with an experimental bioadhesive drug as an adjunct to scaling and root planing in chronic periodontitis – An experimental study

2019 ◽  
Vol 4 (1) ◽  
pp. 18-21
Author(s):  
Randhir Kumar ◽  
Pinak J Kapadia
Keyword(s):  
Drug Delivery ◽  
Experimental Study ◽  
Chronic Periodontitis ◽  
Local Drug Delivery ◽  
Scaling And Root Planing ◽  
Root Planing

scholarly journals Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis – A clinical study

2020 ◽  
Vol 19 (2) ◽  
pp. 427-432
Author(s):  
Raghavendra Reddy Nagate ◽  
M Yuvaraja ◽  
Saad M. AlQahtani ◽  
Nabeeh A. AlQahtani ◽  
Shreyas Tikare ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Green Tea ◽  
Chronic Periodontitis ◽  
Local Drug Delivery ◽  
Periodontal Pocket ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Green Tea Catechin

Purpose: To evaluate the efficacy of pluronic F-127 gel containing green tea catechin extract as a local drug delivery system in the treatment of chronic periodontitis. Methods: A total of 20 chronic periodontitis patients participated as per the set inclusion and exclusion criteria. Complete scaling and root planing (SRP) was done for all subjects and pluronic F-127 gel containing green tea catechin was applied on one site. The contralateral site received SRP alone. The plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded at baseline and on the 28th day. Results: At the 28th-day follow-up, green tea catechin tooth sites showed significantly lower mean scores (GI = 0.55, p = 0.30 and PPD = 3.35 mm) than the corresponding SRP tooth sites (GI = 1.25, PI = 1.15, and PPD = 4.40 mm) (p < 0.05). Conclusion: When compared to scaling and root planing alone, the local drug delivery gel containing green tea catechin as an adjuvant was more effective in reducing the clinical parameters of periodontitis. Keywords: Adjuvant therapy, Camellia sinensis, Local drug delivery, Periodontal pocket

scholarly journals Locally Delivered Tetracycline Fibres in the Treatment of Chronic Periodontitis

2018 ◽  
Vol 2 (2) ◽  
pp. 45-48
Author(s):  
Shristi Kafle ◽  
Shaili Pradhan ◽  
Sujaya Gupta
Keyword(s):  
Drug Delivery ◽  
Chronic Periodontitis ◽  
Clinical Results ◽  
Clinical Findings ◽  
Local Drug Delivery ◽  
Scaling And Root Planing ◽  
Inclusion Criteria ◽  
Root Planing ◽  
Clinical Benefits ◽  
Effective Adjunct

Background: Chronic periodontitis is a highly prevalent and recurrent form of periodontal disease and locally delivered tetracycline fibres are considered to exert tremendous benefits for its treatment. Aim: The aim of the study was to observe the clinical results of locally delivered tetracycline fibres in the treatment of chronic periodontitis. Materials and Methods: Patients aged 35-54 years diagnosed with chronic periodontitis of both gender fulfilling the inclusion criteria were selected. A sample size of 30 was calculated and total number of 60 posterior sites were selected. These sites were divided into two sets in a split mouth design as control sites treated with SRP alone and test sites treated with SRP plus tetracycline fibres. Results: A combination of scaling, root planing and local drug delivery in the form of tetracycline fibres resulted in added benefits in the control of chronic periodontitis on the basis of the clinical findings from this study. Conclusion: This study further adds to the evidence that tetracycline fibres as locally delivered agent are safe and effective adjunct to scaling and root planing, and can produce significant clinical benefits when compared to scaling and root planing alone in the treatment of chronic periodontitis.

scholarly journals Clinical Effects of the Local Drug Delivery Of 0.5% Azithromycin Gel in Treatment of Chronic Periodontitis Among Smokers Versus Non Smokers

2016 ◽  
Vol 04 (02) ◽  
pp. 094-103
Author(s):  
Jasmine Kaur ◽  
Viniti Goel ◽  
Ranjan Malhotra ◽  
Vishakha Grover
Keyword(s):  
Drug Delivery ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Local Drug Delivery ◽  
Clinical Effects ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Root Planing ◽  
Attachment Level

Abstract Background: Along with conventional periodontal surgical therapy, local delivery of antibiotics may provide more effective treatment in smokers by targeting tissue-invasive bacteria. The aim of this randomized, clinical trial was to evaluate the adjunctive effects of subgingivally delivered 0.5% azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis in smokers versus non smokers. Methods: 38 sites in patients of chronic periodontitis were randomized and categorized into two treatment groups: Group 1 consisted of 19 sites in patients who were smokers and Group 2 consisted of 19 sites in non smokers, who received Scaling and Root Planing (SRP) plus 0.5% azithromycin gel Local drug delivery. Clinical parameters were recorded at baseline, 1 and 2 months. They included probing depth (PD) and clinical attachment level (CAL) and percentage bone fill. Results: Azithromycin resulted in significant improvements in both the groups. Mean decrease in PD in non smokers by the end of 2 months was 3.903mm and in smokers was 3.917mm. Gain in CAL in non smokers by the end of 2 months was 3.879mm and in smokers it was 3.920mm. Mean bone fill at one month for smokers was 15.86% and was 26.58% at 2 months. In non-smokers the mean bone fill was 17.19% at 1 month and 24.03% at 2 months. Conclusions: When compared to the non smokers, the adjunctive use of 0.5% AZM resulted in similar improvement in clinical outcome in the treatment of chronic periodontitis among smokers. Local drug delivery of Azithromycin gel contributed to decrease in probing pocket depth, gain in clinical attachment level and in alveolar bone. The apparent bone regeneration also raises the intriguing possibility that Azithromycin encourages bone formation once tissue inflammation has subsided.

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