scholarly journals Clinical Effects of the Local Drug Delivery Of 0.5% Azithromycin Gel in Treatment of Chronic Periodontitis Among Smokers Versus Non Smokers

2016 ◽  
Vol 04 (02) ◽  
pp. 094-103
Author(s):  
Jasmine Kaur ◽  
Viniti Goel ◽  
Ranjan Malhotra ◽  
Vishakha Grover
Keyword(s):  
Drug Delivery ◽  
Chronic Periodontitis ◽  
Alveolar Bone ◽  
Local Drug Delivery ◽  
Clinical Effects ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Root Planing ◽  
Attachment Level

Abstract Background: Along with conventional periodontal surgical therapy, local delivery of antibiotics may provide more effective treatment in smokers by targeting tissue-invasive bacteria. The aim of this randomized, clinical trial was to evaluate the adjunctive effects of subgingivally delivered 0.5% azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis in smokers versus non smokers. Methods: 38 sites in patients of chronic periodontitis were randomized and categorized into two treatment groups: Group 1 consisted of 19 sites in patients who were smokers and Group 2 consisted of 19 sites in non smokers, who received Scaling and Root Planing (SRP) plus 0.5% azithromycin gel Local drug delivery. Clinical parameters were recorded at baseline, 1 and 2 months. They included probing depth (PD) and clinical attachment level (CAL) and percentage bone fill. Results: Azithromycin resulted in significant improvements in both the groups. Mean decrease in PD in non smokers by the end of 2 months was 3.903mm and in smokers was 3.917mm. Gain in CAL in non smokers by the end of 2 months was 3.879mm and in smokers it was 3.920mm. Mean bone fill at one month for smokers was 15.86% and was 26.58% at 2 months. In non-smokers the mean bone fill was 17.19% at 1 month and 24.03% at 2 months. Conclusions: When compared to the non smokers, the adjunctive use of 0.5% AZM resulted in similar improvement in clinical outcome in the treatment of chronic periodontitis among smokers. Local drug delivery of Azithromycin gel contributed to decrease in probing pocket depth, gain in clinical attachment level and in alveolar bone. The apparent bone regeneration also raises the intriguing possibility that Azithromycin encourages bone formation once tissue inflammation has subsided.

scholarly journals Efficacy of Pluronic F-127 gel containing green tea catechin extract on chronic periodontitis – A clinical study

2020 ◽  
Vol 19 (2) ◽  
pp. 427-432
Author(s):  
Raghavendra Reddy Nagate ◽  
M Yuvaraja ◽  
Saad M. AlQahtani ◽  
Nabeeh A. AlQahtani ◽  
Shreyas Tikare ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Green Tea ◽  
Chronic Periodontitis ◽  
Local Drug Delivery ◽  
Periodontal Pocket ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Green Tea Catechin

Purpose: To evaluate the efficacy of pluronic F-127 gel containing green tea catechin extract as a local drug delivery system in the treatment of chronic periodontitis. Methods: A total of 20 chronic periodontitis patients participated as per the set inclusion and exclusion criteria. Complete scaling and root planing (SRP) was done for all subjects and pluronic F-127 gel containing green tea catechin was applied on one site. The contralateral site received SRP alone. The plaque index (PI), gingival index (GI), and probing pocket depth (PPD) were recorded at baseline and on the 28th day. Results: At the 28th-day follow-up, green tea catechin tooth sites showed significantly lower mean scores (GI = 0.55, p = 0.30 and PPD = 3.35 mm) than the corresponding SRP tooth sites (GI = 1.25, PI = 1.15, and PPD = 4.40 mm) (p < 0.05). Conclusion: When compared to scaling and root planing alone, the local drug delivery gel containing green tea catechin as an adjuvant was more effective in reducing the clinical parameters of periodontitis. Keywords: Adjuvant therapy, Camellia sinensis, Local drug delivery, Periodontal pocket

scholarly journals Efficacy of 2% ibuprofen subgingival irrigation as an adjunct to non-surgical therapy in the treatment of chronic periodontitis: A randomized controlled, split-mouth, clinical trial

2019 ◽  
Vol 11 (2) ◽  
pp. 69-76
Author(s):  
Amirhossein Farahmand ◽  
Ferena Sayar ◽  
Zohreh Omidali ◽  
Mahsa Soleimani ◽  
Bahareh Jafarzadeh Esfahani
Keyword(s):  
Clinical Trial ◽  
Chronic Periodontitis ◽  
Periodontal Treatment ◽  
Periodontal Pocket ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Root Planing ◽  
Mandibular Molar ◽  
Attachment Level

Background. Pharmacological factors, such as ibuprofen, released topically in the periodontal pocket modulate the host response and enhance the influence of non-surgical periodontal treatment. Methods. In this double-blind, randomized, split-mouth, clinical trial, 38 outpatients with mild to moderate chronic periodontitis were enrolled by applying the simple random sampling method. They had at least one tooth with a periodontal pocket depth of >4 mm in each quadrant and had undergone phase I of periodontal treatment one week after scaling and root planing (SRP). The parameters of clinical periodontal evaluation, including probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI), and bleeding index (BI), were measured. In addition, two mandibular molar teeth in one quadrant were randomly nominated for subgingival irrigation with 0.5 mL of 2% ibuprofen or placebo mouthwash. The measurements were repeated after at least one week for three months. Results. Thirty-four individuals (18 women and 16 men), with an age range of 28‒36 years, were evaluated for three months. Moreover, periodontal clinical parameters were assessed within three months. There was a significant improvement in pocket depth (PD) and clinical attachment level (CAL) readings after 12 weeks in both groups (paired t-test). On comparing, the group with scaling and root planing (SRP) + ibuprofen showed more favorable results than the group with SRP + placebo (P<0.05). There were significant improvements in PI and BI in both groups; the differences between the two groups were significant (P<0.05). Conclusion. The mouthwashes containing ibuprofen might reduce the symptoms of periodontal disease and might be used as an adjunct in the healing process

scholarly journals Laser Assisted Non-surgical Periodontal Therapy: A Double Blind, Randomized Clinical Trial

2017 ◽  
Vol 11 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Joseph D. Everett ◽  
Jeffrey A. Rossmann ◽  
David G. Kerns ◽  
Ibtisam Al-Hashimi
Keyword(s):  
Laser Therapy ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Clinical Attachment Level ◽  
Laboratory Parameters ◽  
Root Planing ◽  
Significant Difference ◽  
Attachment Level

The objective of this study was to examine potential benefits of using laser therapy for secular decontamination in conjunction with scaling and root planing in the treatment of chronic periodontitis. The study was performed on 173 teeth in 14 patients in a split-mouth design, one side received scaling and root planing followed by laser therapy using a carbon dioxide (CO2) laser with an ablative handpiece (test group); the contralateral side received scaling and root planing without laser (control group). Clinical and laboratory parameters were evaluated prior to treatment and at 3 and 6 months following therapy; clinical measurements were performed by two blinded examiners. The clinical parameters included measurement of gingival recession (REC), bleeding on probing (BOP), clinical attachment level (CAL), pocket depth (PD), furcation involvement (FUR), and tooth mobility (MOB). Laboratory testing to determine the levels of periodontal pathogens was performed using PCR techniques. The results of the study revealed statistically significant differences in clinical and laboratory parameters at 3 and 6 months after therapy for both test and control groups, but no significant difference was observed between the two groups. However, sites receiving laser therapy tended to show a greater decrease in probing depths, gain in clinical attachment level, and reduced bacterial levels. In conclusion, the overall results of the study suggest a potential benefit of using laser therapy in conjunction with scaling and root planing for the treatment of chronic periodontitis.

Comparison of Clinical Attachment Level Gain Using Scaling Root Planing Versus Adjunctive Azithromycin on Chronic Periodontitis

2021 ◽  
Vol 15 (8) ◽  
pp. 2054-2056
Author(s):  
Attique ur Rehman ◽  
Marryam Riaz ◽  
Moeez Ansari ◽  
Saqib Naeem Sidiqui ◽  
Adeel Ijaz Rana ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
P Value ◽  
Scaling And Root Planing ◽  
Test Results ◽  
Once Daily ◽  
Clinical Attachment Level ◽  
Root Planing ◽  
Effective Treatment Modality ◽  
Periodontal Debridement ◽  
Attachment Level

Objective: The objective of the study was to compare the mean clinical attachment gain in patients of chronic periodontitis after scaling and root alone versus Azithromycin as an adjunct to scaling and root. Study Design Comparative study Place and Duration: Conducted at Operative Dentistry Department, Azra Naheed Dental College, Lahore for a duration of 4 months from December 2019 to March 2020. Methodology: Total Sixty patients fulfilling the selection criteria were randomly allocated to SRP and SRP+Az groups. In both groups, conventional scaling and root planing was done. In the SRP group placebo capsules were prescribed, while in the SRP+Az group, Azithromycin (500mg) once daily was prescribed for 3 days. Clinical attachment level (CAL) was measured initially and after 5 weeks. Data was analyzed in SPSS version 19.0 using independent sample t-test. Results: Both groups showed gain in CAL compared to baseline. However, SRP+Az group showed significantly more gain in CAL in comparison to SRP group (P value < 0.05). Conclusion: Use of Azithromycin adjunctive to SRP is an effective treatment modality in chronic periodontitis patients. Keywords: Anti‐Bacterial Agents, Azithromycin, Chronic periodontitis, Clinical attachment level, Periodontal Debridement, Scaling and root planing,

Platelet-rich Plasma with Scaling and Root Planing: A Double-blind Split-mouth Randomized Study

2014 ◽  
Vol 6 (2) ◽  
pp. 35-39
Author(s):  
Ashish Agarwal ◽  
Narinder Dev Gupta
Keyword(s):  
Chronic Periodontitis ◽  
Platelet Rich Plasma ◽  
Randomized Study ◽  
Response To Treatment ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Double Blind ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Attachment Level

Background and aims. Along with conventional periodontal therapy, subginigval application of platelet-rich plasma (PRP) may provide more effective improvements in clinical parameters due to the presence of multiple growth factors. The aim of this double-blind, split-mouth, randomized study was to evaluate the adjunctive use of PRP with scaling and root planing (SRP) in the treatment of chronic periodontitis. Materials and methods. A total of 87 non-smokers suffering from moderate to severe chronic periodontitis were selected. Parameters were probing pocket depth (PPD), clinical attachment level (CAL), plaque index (PI) and modified bleeding index (mBI). After full-mouth SRP the sites were randomly divided into experimental sites receiving subgingival application of autologous PRP and controls treated with placebo gel. Measurements were recorded at baseline, 3 months and 6 months. Paired t-test was used to compare response to treatment between the two sites. Results. Statistically significant changes in parameters were seen in both groups from baseline to 6 months. Inter-group comparison revealed significantly more clinical attachment gain for the experimental group (P>0.05). The mean CAL gain was 2.40±0.4 mm for control sites and 2.68±0.5 mm for experimental sites. Conclusion. This study supports the use of PRP during nonsurgical debridement of periodontal pockets measured 6 months after SRP.

scholarly journals Locally Delivered Tetracycline Fibres in the Treatment of Chronic Periodontitis

2018 ◽  
Vol 2 (2) ◽  
pp. 45-48
Author(s):  
Shristi Kafle ◽  
Shaili Pradhan ◽  
Sujaya Gupta
Keyword(s):  
Drug Delivery ◽  
Chronic Periodontitis ◽  
Clinical Results ◽  
Clinical Findings ◽  
Local Drug Delivery ◽  
Scaling And Root Planing ◽  
Inclusion Criteria ◽  
Root Planing ◽  
Clinical Benefits ◽  
Effective Adjunct

Background: Chronic periodontitis is a highly prevalent and recurrent form of periodontal disease and locally delivered tetracycline fibres are considered to exert tremendous benefits for its treatment. Aim: The aim of the study was to observe the clinical results of locally delivered tetracycline fibres in the treatment of chronic periodontitis. Materials and Methods: Patients aged 35-54 years diagnosed with chronic periodontitis of both gender fulfilling the inclusion criteria were selected. A sample size of 30 was calculated and total number of 60 posterior sites were selected. These sites were divided into two sets in a split mouth design as control sites treated with SRP alone and test sites treated with SRP plus tetracycline fibres. Results: A combination of scaling, root planing and local drug delivery in the form of tetracycline fibres resulted in added benefits in the control of chronic periodontitis on the basis of the clinical findings from this study. Conclusion: This study further adds to the evidence that tetracycline fibres as locally delivered agent are safe and effective adjunct to scaling and root planing, and can produce significant clinical benefits when compared to scaling and root planing alone in the treatment of chronic periodontitis.

Sign in / Sign up

Export Citation Format

Share Document