The 22nd International Florida Artificial Intelligence Research Society Conference (FLAIRS-22) was held 19th – 21st May 2009 at the Sundial Beach and Golf Resort on Sanibel Island, Florida, USA. It continued a long tradition of FLAIRS conferences, which attract researchers from around the world. The conference featured technical papers, special tracks, and invited speakers. This year’s conference was chaired by Susan Haller, from the State University of New York at Potsdam. Conference program co-chairs were Hans W. Guesgen, from Massey University in New Zealand, and H. Chad Lane, from the University of Southern California. The special tracks were coordinated by Philip McCarthy, from the University of Memphis.