Soil pollution is the important part of environmental pollution which affects the quality of agricultural products and safety of human health. taking Poyang Lake Ecological Economic Zone as the specific study object, on the basis of an overview of soil pollution status quo in the area, the soil pollution prevention plan of Poyang Lake Ecological Economic Zone was probed into which included the guiding ideology and principles, the planning target and indicators, soil function zoning, planning content and planning measures, while the planning content includes emphasis content plan of agricultural soil pollution prevention and contaminated sites ecological restoration, emphasis pollutants plan, emphasis regional plan, emphasis industries plan and emphasis project plan. It can improve the soil environment quality of Poyang Lake ecological Economic Zone to provide environmental guarantee for sustained and healthy development in the area.