scholarly journals Pulmonary Function Test Outcomes in Adult Omani Patients

2021 ◽  
Author(s):  
Anan Al Jabri ◽  
Ruqaiya Al Hinai ◽  
Ruth Balaji ◽  
Sharifa Al Harrasi ◽  
Hajar Al Rajaibi ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Pulmonary Diseases ◽  
Chronic Obstructive ◽  
Limited Information ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Function Tests

Objectives: There is limited information regarding distribution of Pulmonary Diseases (PD) in Oman. Pulmonary Function Tests (PFT) outcome patterns could be a pointer to an indirect indication of the distribution of PD. This study aimed to document distribution of PFT outcomes among Omani adult patients. Methods: This retrospective cross-sectional study was conducted from January to December 2015 at a tertiary hospital in Oman. A total of 1,118 adults referred for PFTs during this period were included. Results: There were 605 (54.1%) female and 513 (45.9%) male patients. The mean age was 47.11±18.1 years. Most underwent spirometry with reversibility (36.8%) or full lung function testing with reversibility (29.7%). Of the 1,064 patients with conclusive PFT outcomes, 39.9% had normal findings, followed by 26.1% with obstructive defects, 19.6% restrictive defects and 10.6% had mixed obstructive/restrictive defects. Conclusion: This study generated important preliminary data regarding PFT outcomes (defects) in Omani patients. Keywords: Pulmonary Function Tests; Spirometry; Pulmonary Diseases; Asthma; Chronic Obstructive Pulmonary Disease; Oman.

scholarly journals Multi detector computed tomography evaluation in chronic obstructive pulmonary disease and correlation with severity of disease

2019 ◽  
Vol 7 (8) ◽  
pp. 3116
Author(s):  
Ajay Kumar ◽  
Ankita Rohira ◽  
Ashish Vijay ◽  
Abhay Sharma
Keyword(s):  
Computed Tomography ◽  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Function ◽  
Pulmonary Disease ◽  
Pulmonary Function Tests ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Function Tests ◽  
Invaluable Tool ◽  
Multi Detector Computed Tomography

Background: Multi Detector computed tomography (MDCT) may effectively characterize and quantify the extent of emphysema and the air trapping related to the small airway’s disease. Here we highlight the computed-tomography findings of Chronic Obstructive Pulmonary Disease (COPD) and correlation with the Spirometrics values.Methods: The study group included the total of 100 adult patients of either sex with a clinical suspicion of COPD and those who undergone MDCT of thorax. Lung function of the patients with the COPD stages mild to very severe was evaluated by both the MDCT and Spirometrics Pulmonary Function Tests (PFTs). The scanning was done at maximum end inspiration and maximum end expiration.Results: There was a preponderance of male patients with highly significant correlation between values of mean lung density and low attenuation values (p<0.000I). MDCT correlated well with those obtained from spirometric Pulmonary Function Tests in the patients with COPD and that the correlation at expiration was superior to that at inspiration.Conclusions: The study concludes that Multi-detector computed tomography is the invaluable tool in defining and quantifying COPD and the characterization of emphysematous changes.

scholarly journals A Cross-Sectional Study of Nemaline Myopathy

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000011458
Author(s):  
Kimberly Amburgey ◽  
Meryl Acker ◽  
Samia Saeed ◽  
Reshma Amin ◽  
Alan H. Beggs ◽  
...  
Keyword(s):  
Pulmonary Function ◽  
Outcome Measures ◽  
Pulmonary Function Tests ◽  
Severe Disease ◽  
Nemaline Myopathy ◽  
Cross Sectional Study ◽  
Longitudinal Assessment ◽  
Sectional Study ◽  
Cross Sectional ◽  
Function Tests

Objective:Nemaline myopathy (NM) is a rare neuromuscular condition with clinical and genetic heterogeneity. To establish disease natural history, we performed a cross-sectional study of NM, complemented by longitudinal assessment and exploration of pilot outcome measures.Methods:Fifty-seven individuals with NM were recruited at two family workshops, including 16 examined at both time points. Subjects were evaluated by clinical history and physical examination. Functional outcome measures included the Motor Function Measure (MFM), pulmonary function tests (PFTs), myometry, goniometry, and bulbar assessments.Results:The most common clinical classification was “typical congenital” (54%), whereas 42% had more severe presentations. 58% of individuals needed mechanical support, with 26% requiring wheelchair, tracheostomy, and feeding tube. The MFM scale was performed in 44/57 participants and showed reduced scores in most with little floor/ceiling effect. Of the 27 individuals completing PFTs, abnormal values were observed in 65%. Lastly, bulbar function was abnormal in all patients examined, as determined using a novel outcome measure. Genotypes included mutations in ACTA1 (18), NEB (20), and TPM2 (2). Seventeen individuals were genetically unresolved. Patients with pathogenic ACTA1 and NEB variants were largely similar in clinical phenotype. Patients without genetic resolution had more severe disease.Conclusion:In all, we present a comprehensive cross-sectional study of NM. Our data identify significant disabilities and support a relatively stable disease course. We identify a need for further diagnostic investigation for the genetically unresolved group. Lastly, MFM, pulmonary function tests, and the slurp test were identified as promising outcome measures for future clinical trials.

scholarly journals Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort

2020 ◽  
Vol 17 (19) ◽  
pp. 7085
Author(s):  
Subhabrata Moitra ◽  
Ali Farshchi Tabrizi ◽  
Kawtar Idrissi Machichi ◽  
Samineh Kamravaei ◽  
Noushin Miandashti ◽  
...  
Keyword(s):  
Occupational Exposure ◽  
Pulmonary Function Tests ◽  
Prevalence Ratio ◽  
Cross Sectional Study ◽  
Chronic Obstructive ◽  
Ceramic Fibers ◽  
Cross Sectional ◽  
Obstructive Pulmonary Disease ◽  
Insulating Materials ◽  
Respiratory Illnesses

Many insulating materials are used in construction, although few have been reported to cause non-malignant respiratory illnesses. We aimed to investigate associations between exposures to insulating materials and non-malignant respiratory illnesses in insulators. In this cross-sectional study, 990 insulators (45 ± 14 years) were screened from 2011–2017 in Alberta. All participants underwent pulmonary function tests and chest radiography. Demographics, work history, and history of chest infections were obtained through questionnaires. Chronic obstructive pulmonary disease (COPD) was diagnosed according to established guidelines. Associations between exposures and respiratory illnesses were assessed by modified Poisson regression. Of those screened, 875 (88%) were males. 457 (46%) participants reported having ≥ 1 chest infection in the past 3 years, while 156 (16%) were diagnosed with COPD. In multivariate models, all materials (asbestos, calcium silicate, carbon fibers, fiberglass, and refractory ceramic fibers) except aerogels and mineral fibers were associated with recurrent chest infections (prevalence ratio [PR] range: 1.18–1.42). Only asbestos was associated with COPD (PR: 1.44; 95% confidence interval [CI]: 1.01, 2.05). Therefore, occupational exposure to insulating materials was associated with non-malignant respiratory illnesses, specifically, recurrent chest infections and COPD. Longitudinal studies are urgently needed to assess the risk of exposure to these newly implemented insulation materials.

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