scholarly journals A single nucleotide polymorphism in BCAT1 gene is associated with type 2 diabetes mellitus

2021 ◽  
Author(s):  
Mahmoud A. Alfaqih ◽  
Zaina E. Abu-Khdair ◽  
Omar Khabour ◽  
Khalid A. Kheirallah ◽  
Mariam Khanfar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Glucose ◽  
Branched Chain Amino Acid ◽  
Transamination Reaction ◽  
Inheritance Model ◽  
Branched Chain ◽  
Obesity And Cancer

The level of circulatory branched chain amino acids (BCAAs) is often increased in type 2 diabetes mellitus (T2DM). Catabolism of BCAAs involves a transamination reaction mediated by the branched chain amino acid aminotransferase (BCAT1) enzyme. Differences in the level of BCAT1 were found to be linked with hypertension, obesity, and cancer. Herein, using a case control design, we tested the association of rs9668920 and rs12321766 polymorphisms in BCAT1 gene with T2DM. Three hundred subjects were recruited in the study. Genotyping of the indicated polymorphisms was achieved using restriction fragment length polymorphism technique after amplification of the target sequences. The results showed that, under a recessive inheritance model, the GG genotype of rs9668920 increased the risk of T2DM (P=0.026; OR 2.60; 95% CI 1.119–6.048). This effect was independent of the age, body mass index, waist circumference, serum glucose, cholesterol, triglycerides, and BCAAs (P>0.05). In conclusion, The GG genotype of BCAT1 rs9668920 SNP might be a risk factor of T2DM. More studies are required to confirm this finding.

scholarly journals The Effects of Natural Nano-Sized Clinoptilolite and Metformin on the Levels of Serum Glucose, Lipid Profile, and Minerals in Rats with Type 2 Diabetes Mellitus

2018 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Ali Tarighat-Esfanjani ◽  
Habib Fallahnejad ◽  
Hosein Omidi ◽  
Mohammad Asghari Jafarabadi ◽  
Mehran Mesgari Abbasi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Lipid Profile ◽  
Serum Glucose

scholarly journals The Effect ofTinospora crispaon Serum Glucose and Insulin Levels in Patients with Type 2 Diabetes Mellitus

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Theerawut Klangjareonchai ◽  
Chulaporn Roongpisuthipong
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Healthy Subjects ◽  
Statistical Significance ◽  
Area Under The Curve ◽  
Serum Glucose ◽  
Dry Powder ◽  
Insulin Levels

Objective. To determine the effects ofTinospora crispaon serum glucose and insulin levels in healthy subjects and patients with type 2 diabetes mellitus.Method. Serum from 10 healthy subjects and 10 diabetic participants, who had fasted overnight, were obtained every 30–60 minutes during the 3 hours of continued fasting and during the 3 hours after ingestion of 75 g of glucose with or without ingestion of 125 or 250 g ofTinospora crispadry powder capsule. Glucose and Insulin levels were analyzed and the areas under the curve for mean serum glucose and insulin levels were calculated.Result. The areas under the curve of mean serum glucose and insulin levels in both healthy and diabetic participants were not significantly different between with or withoutTinospora crispadry powder capsule. In diabetic participants the area under the curve of glucose was slightly lesser when 250 mg ofTinospora crispawas ingested, but not reaching statistical significance (478 and 444 mg min/ml, resp.,P=0.57).Conclusion. The results suggest thatTinospora crispaingestion cannot affect serum glucose and insulin levels in healthy subjects or patients with type 2 diabetes mellitus.

scholarly journals The rs1014290 Polymorphism of the SLC2A9 Gene Is Associated with Type 2 Diabetes Mellitus in Han Chinese

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Wan-Chun Liu ◽  
Chi-Chih Hung ◽  
Szu-Chia Chen ◽  
Ming-Yen Lin ◽  
Ling-I Chen ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Uric Acid ◽  
Glucose Transporter ◽  
Serum Glucose ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Type 2 Dm

Aims. TheSLC2A9gene encodes the glucose transporter 9, with the abilities of transporting both glucose and uric acid and is involved in the pancreatic glucose-stimulated insulin secretion. The single nucleotide polymorphisms (SNPs) ofSLC2A9accounted for 5% variance of serum uric acid (UA). UA was identified as a risk factor for type 2 diabetes mellitus (DM). We investigated whether theSLC2A9gene variations are associated with type 2 DM in Han Chinese.Methods. Three common SNPs of theSLC2A9, rs1014290, rs2280205, and rs3733591, were genotyped in 1003 Han Chinese randomly selected from Kaohsiung, Taiwan.Results. The variant SNP rs1014290 is associated with decreased 0.12-fold risk of type 2 DM (P=.002). Per-copy increase in the minor C-allele results in 0.13 mmol/L (P=.037) and 10.03 μmol/L (P=.016) decrease in serum glucose and UA, respectively.Conclusions. The SNP rs1014290 within theSLC2A9gene is associated with type 2 DM in Han Chinese.

Elimination of infused branched-chain amino-acids from plasma of patients with non-obese type 2 diabetes mellitus

1991 ◽  
Vol 10 (2) ◽  
pp. 105-113 ◽  
Author(s):  
G. Marchesini ◽  
G.P. Bianchi ◽  
H. Vilstrup ◽  
M. Capelli ◽  
M. Zoli ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Amino Acids ◽  
Type 2 Diabetes Mellitus ◽  
Branched Chain Amino Acids ◽  
Branched Chain
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