scholarly journals Determination of critical quality parameters during tablet development fludarabine phosphate

2019 ◽  
Author(s):  
K.V. Alekseev ◽  
D.V. YUdina ◽  
V.K. Alekseev ◽  
E.V. Dvornik ◽  
E.S. Klochkova ◽  
...  
2018 ◽  
Vol 28 ◽  
pp. 35-42
Author(s):  
David Black ◽  
Bryan Found ◽  
Doug Rogers

Forensic Document Examiners (FDEs) examine the physical morphology and performance attributes of a line trace when comparing questioned to specimen handwriting samples for the purpose of determining authorship. Along with spatial features, the elements of execution of the handwriting are thought to provide information as to whether or not a questioned sample is the product of a disguise or simulation process. Line features such as tremor, pen-lifts, blunt beginning and terminating strokes, indicators of relative speed, splicing and touch ups, are subjectively assessed and used in comparisons by FDEs and can contribute to the formation of an opinion as to the validity of a questioned sample of handwriting or signatures. In spite of the routine use of features such as these, there is little information available regarding the relative frequency of occurrence of these features in populations of disguised and simulated samples when compared to a large population of a single individual’s signature. This study describes a survey of the occurrence of these features in 46 disguised signatures, 620 simulated signatures (produced by 31 different amateur forgers) and 177 genuine signatures. It was found that the presence of splices and touch-ups were particularly good predictors of the simulation process and that all line quality parameters were potentially useful contributors in the determination of the authenticity of questioned signatures. Purchase Article - $10


1997 ◽  
Vol 5 (3) ◽  
pp. 135-148 ◽  
Author(s):  
S. Sollinger ◽  
M. Voges

The production of cellulose fibres by wet fibres spinning requires a careful monitoring of the spinning bath and especially the spinning solution in terms of product control and for quality assurance purposes. The chemical composition as well as the ripening of the spinning solution are of major importance for maintaining a constant product quality. The conventional determination of the quality parameters of the viscose spinning solution are rather time- and labour-intensive due to the fact that several independent analytical procedures are involved which score low in time efficiency themselves. Briefly, the complete characterisation of the spinning solution requires an iodometric titration of the cellulose xanthogenate (γ-number), an acidimetric titration of the sodium hydroxide (NaOH) content, a UV-VIS spectroscopic determination of the trithiocarbonate (TTC) content and a time-consuming gravimetric cellulose content determination. Sometimes, also, a colloid chemical determination of the degree of ripening (Hottenroth number) is performed in the plant control laboratory. With this work, an approach will be demonstrated, which enables the substitution of these numerous analytical procedures by a single and time-efficient method—a VIS-NIR spectroscopic technique. Therefore, it is possible to determine the parameters: NaOH, TTC, cellulose xanthogenate content and the cellulose content of the viscose spinning solution simultaneously with a reasonable precision within a few minutes.


2021 ◽  
Vol 27 (3) ◽  
pp. 223-232
Author(s):  
Anna Wysocka-Rabin ◽  
Magdalena Dobrzyńska ◽  
Katarzyna Pasicz ◽  
Witold Skrzyński ◽  
Ewa Fabiszewska

Abstract Introduction: Advances in digital detector technology and methods of image presentation in digital mammography now offer the possibility of implementing mathematical assessment methods to quantitative image analysis. The aim of this work was to develop new software to simplify the application of the existing international standard for DQE in digital mammography and show in detail how it can be applied, using a Siemens Mammomat Inspiration as a model. Material and methods: Consistent with the IEC standard a 2 mm Al filter at the tube exit and images in DICOM format as raw data, without applying any additional post-processing were used. Measurements were performed for W/Rh anode/filter combination and different tube voltage values (26 ÷ 34 kV) without any anti-scatter grid. To verify new software doses ranging from 20-600 µGy were used in measurements. Exposure (air kerma) was measured using a calibrated radiation meter (Piranha Black 457, RTI Electronics AB, Sweden). MTF was determined, using an edge test device constructed specifically for this work. Results: It has been demonstrated that with the new software the DQE can be measured with the accuracy required by the international standard IEC 62220-1-2. DQE has been presented as a function of spatial frequency for W/Rh anode/filter combination and different tube voltage. Conclusions: New software was used successfully to analyze image quality parameters for the Siemens Mammomat Inspiration detector. This was done on the basis of an internationally accepted methodology. In the next step, mammographs with different detector types can be compared.


2018 ◽  
Vol 6 (4) ◽  
pp. 1109-1118 ◽  
Author(s):  
Zhenying Zhu ◽  
Shangbing Chen ◽  
Xueyou Wu ◽  
Changrui Xing ◽  
Jian Yuan

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