scholarly journals N-ALKENYLIMIDAZOLE METAL COMPLEX DERIVATIVES AS EFFECTIVE AGENTS FOR THE HYPOXIC CONDITIONS

Author(s):  
S.A. Shakhmardanova ◽  
◽  
P.A. Galenko-Yaroshevsky ◽  
1957 ◽  
Vol 12 (1_2) ◽  
pp. 96-109 ◽  
Author(s):  
Andrew Gemant
Keyword(s):  

2020 ◽  
Vol 2 (1) ◽  
pp. 1-12
Author(s):  
Gulgina Mamtimin ◽  
Halisa Arkin ◽  
Patima Nizamidin ◽  
Erkin Tursun ◽  
Abliz Yimit

Author(s):  
Sandhya MNVS ◽  
Vanitha K ◽  
Ramesh A

The review article focuses on the importance of adequate oxygen levels in the body as cure and therapy for many ailments. It is known that hypoxia is the cause for cellular damage and if it can be applied to major patho-physiology’s, it can be observed that slow and chronic hypoxic conditions are the cause for most of the diseases. On the contrary, providing each cell of the body with proper oxygen may be helpful in maintaining the immunity of the body and therefore treating many disease conditions. This theory, if tested may show positive results in heart related diseases, neuronal disorders, stresses, digestive disorders and the unresolved cancer too. Slow decrease in the levels of atmospheric oxygen could be a reason to induce chronic hypoxia. According to Dr. Otto Warburg, a Noble laurate, a normal cell when deprived of oxygen, may get converted to a cancerous cell, whereas a cancerous cell cannot survive in aerobic conditions. If this part of his research be concentrated on, there could be fruitful results in the treatment of cancer. To maintain adequate levels of oxygen in the body, simple yogic breathing practices are helpful. And to maintain the adequate atmospheric oxygen, trees and plants which cleanse the atmospheric air are useful. Clinical surveys on volunteers who have been practicing regular breathing exercises can prove the fact that proper and concentrated respiration could prevent many diseases. Thus, supplementing breathing exercises along with the regular treatment for cancer patients could be helpful in alleviating cancer and other diseases.


1991 ◽  
Vol 62-64 ◽  
pp. 513-514
Author(s):  
N.D. Kushch ◽  
A.A. Ignatiev ◽  
V.N. Laukhin ◽  
M.K. Makova ◽  
V.A. Merzhanov ◽  
...  

Synthesis ◽  
2021 ◽  
Author(s):  
Sambasivarao Kotha ◽  
Sunil Pulletikurti ◽  
Ambareen Fatma ◽  
gopal dhangar ◽  
gonna somu Naidu

Here, we have demonstrated that the presence of a carbonyl group at C7 position is preventing the olefin metathesis of endo-norbornene derivatives due to the complexation of the metal alkylidene. Time-dependent NMR studies showed the presence of new proton signals in the metal alkylidene region, which indicate the formation of metal complex with the carbonyl group of the substrate. These observations were further proved by ESI-MS analysis. Whereas, computational studies provided that the catalyst was interacting with the C7 carbonyl group and aligned perpendicular to that of norbornene olefin. Later, these endo-keto norbornene derivatives were reduced to hydroxyl derivatives diastereoselectively. Ring-rearrangement metathesis (RRM) of these hydroxyl derivatives, produced the [6/5/6], and [5/6/5] carbo-tricyclic cores of the natural products in one step. Whereas the RRM of O-allyl derivatives, delivered the oxa-tricyclic compounds in a single step with excellent yields.


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