Chronic Hypoxia as a Potential Factor in Human Life-threatening Diseases

2017 ◽  
Vol 10 (4) ◽  
pp. 3759-3762
Author(s):  
Sandhya MNVS ◽  
Vanitha K ◽  
Ramesh A
Keyword(s):  
Chronic Hypoxia ◽  
Atmospheric Oxygen ◽  
Human Life ◽  
The Body ◽  
Cellular Damage ◽  
Otto Warburg ◽  
Regular Treatment ◽  
Breathing Exercises ◽  
Hypoxic Conditions ◽  
Cancerous Cell

The review article focuses on the importance of adequate oxygen levels in the body as cure and therapy for many ailments. It is known that hypoxia is the cause for cellular damage and if it can be applied to major patho-physiology’s, it can be observed that slow and chronic hypoxic conditions are the cause for most of the diseases. On the contrary, providing each cell of the body with proper oxygen may be helpful in maintaining the immunity of the body and therefore treating many disease conditions. This theory, if tested may show positive results in heart related diseases, neuronal disorders, stresses, digestive disorders and the unresolved cancer too. Slow decrease in the levels of atmospheric oxygen could be a reason to induce chronic hypoxia. According to Dr. Otto Warburg, a Noble laurate, a normal cell when deprived of oxygen, may get converted to a cancerous cell, whereas a cancerous cell cannot survive in aerobic conditions. If this part of his research be concentrated on, there could be fruitful results in the treatment of cancer. To maintain adequate levels of oxygen in the body, simple yogic breathing practices are helpful. And to maintain the adequate atmospheric oxygen, trees and plants which cleanse the atmospheric air are useful. Clinical surveys on volunteers who have been practicing regular breathing exercises can prove the fact that proper and concentrated respiration could prevent many diseases. Thus, supplementing breathing exercises along with the regular treatment for cancer patients could be helpful in alleviating cancer and other diseases.

Respiratory gymnastics as a means of strengthening the health of student youth

2021 ◽  
pp. 135-137
Author(s):  
N. Shashlov
Keyword(s):  
Healthy Lifestyle ◽  
Human Life ◽  
Effective Means ◽  
Specific Effect ◽  
The Body ◽  
External Respiration ◽  
State Of Health ◽  
Critical Systems ◽  
Breathing Exercises ◽  
Current State

The article analyzes the current state of health of students of higher education institutions. The importance of breathing exercises for student youth in a pandemic is determined. The necessity of using respiratory techniques to harden the body, improve the work of the respiratory and cardiovascular systems is substantiated. It is established that breathing exercises are a system of breathing exercises and an effective means of strengthening human health. During respiratory gymnastics our body is saturated with oxygen, blood circulation improves, metabolic processes are accelerated, emotional state is stabilized, immunity is strengthened. Breathing exercises improve and activate the function of external respiration, promote its faster recovery after exercise and have a specific effect on some respiratory diseases. Health is the main value of human life, to which man himself does not pay due attention. An important preventive factor in strengthening it is a healthy lifestyle. There are basic requirements for maintaining a healthy lifestyle - physical activity, nutrition, comfortable conditions and a rational mode of work and rest, optimal exercise, abandonment of bad habits, the use of traditional and non-traditional means of health. The problem of health, especially of students, is receiving more and more attention. The state of health of students can be classified as high risk. The transition from one learning environment to another, more intensive, requires the body of the future student to pay more attention to the work of critical systems, including respiratory. There are many issues related to the formation of new approaches to health promotion.

Protective Effect of Silybum marianum and Nigella sativa Oil Extracts against Cisplatin Induced Nephrotoxicity in Mice

2018 ◽  
Vol 18 (2) ◽  
pp. 171-175
Author(s):  
Ashraf A. ◽  
Hassan F. ◽  
Batool S. ◽  
Nadeem M. ◽  
Irshad M. ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Petroleum Ether ◽  
Nigella Sativa ◽  
Histological Study ◽  
The Body ◽  
Cellular Damage ◽  
Elevated Blood ◽  
Silybum Marianum ◽  
Elevated Blood Glucose

The objective of present study was to analyze and compare the nephroprotective effects of petroleum ether extracts of seeds of Nigella sativa and Silybum marianum in Swiss albino mice. Petroleum ether extracts of seeds of Nigella sativa and Silybum marianum were administered (200 mg kg–1) orally for 14 days following one dose of cisplatin injection (16 mg kg–1 i.p.) on 4th day. Cisplatin toxicity was identified in mice by loss of body weight, reduced triglycerides levels, elevated blood glucose, blood urea nitrogen and creatinine levels (P < 0.05). Silybum marianum and Nigella sativa significantly enhanced the body weight (9%) of diabetic rats. Silybum marianum had significantly reduced the elevated blood glucose (–106%), and BUN levels (–9%) as compared to the Nigella sativa administration. Silybum marianum extract also significantly elevated the levels of triglycerides (257%) which were much reduced after the cisplatin injection. Histological study showed that the cisplatin treated group demonstrated the necrosis signs in the glomerulus of Bowman’s capsule, hyalinization and severe cellular damage. The animals administered with extracts showed nearly normal kidney architecture, however, the kidney tissues of Silybum marianum-treated animals showed some improvement with slight signs of cellular damages.

Molecular Targets of Phytochemicals for Skin Inflammation

2018 ◽  
Vol 24 (14) ◽  
pp. 1533-1550 ◽  
Author(s):  
Jong-Eun Kim ◽  
Ki Won Lee
Keyword(s):  
Skin Diseases ◽  
Molecular Targets ◽  
Skin Inflammation ◽  
Mechanisms Of Action ◽  
The Body ◽  
Cellular Damage ◽  
Aesthetic Appearance ◽  
Immune Mediated ◽  
Skin Conditions ◽  
Effects Of Aging

Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked. Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals have been identified and their precise mechanisms of action investigated. In this review, we summarize recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.

Mechanisms of Nickel-Induced Cell Damage in Allergic Contact Dermatitis and Nutritional Intervention Strategies

2020 ◽  
Vol 20 (7) ◽  
pp. 1010-1014 ◽  
Author(s):  
Dana Filatova ◽  
Christine Cherpak
Keyword(s):  
Lipid Peroxidation ◽  
Contact Dermatitis ◽  
Oxidative Damage ◽  
Allergic Contact Dermatitis ◽  
Cell Damage ◽  
Consumer Products ◽  
The Body ◽  
Cellular Damage ◽  
Nutritional Interventions ◽  
Allergic Contact

Background: Hypersensitivity to nickel is a very common cause of allergic contact dermatitis since this metal is largely present in industrial and consumer products as well as in some commonly consumed foods, air, soil, and water. In nickel-sensitized individuals, a cell-mediated delayed hypersensitivity response results in contact to dermatitis due to mucous membranes coming in long-term contact with nickel-containing objects. This process involves the generation of reactive oxidative species and lipid peroxidation-induced oxidative damage. Immunologically, the involvement of T helper (h)-1 and Th-2 cells, as well as the reduced function of T regulatory cells, are of importance. The toxicity, mutagenicity, and carcinogenicity of nickel are attributed to the generation of reactive oxygen species and induction of oxidative damage via lipid peroxidation, which results in DNA damage. Objective: The aim of this research is to identify nutritionally actionable interventions that can intercept nickel-induced cell damage due to their antioxidant capacities. Conclusion: Nutritional interventions may be used to modulate immune dysregulation, thereby intercepting nickel-induced cellular damage. Among these nutritional interventions are a low-nickel diet and an antioxidant-rich diet that is sufficient in iron needed to minimize nickel absorption. These dietary approaches not only reduce the likelihood of nickel toxicity by minimizing nickel exposure but also help prevent oxidative damage by supplying the body with antioxidants that neutralize free radicals.

scholarly journals Migration of Silver and Copper Nanoparticles from Food Coating

Coatings ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 380
Author(s):  
Hamed Ahari ◽  
Leila Khoshboui Lahijani
Keyword(s):  
Copper Nanoparticles ◽  
Inductively Coupled Plasma ◽  
Food Packaging ◽  
Human Life ◽  
Analytical Techniques ◽  
Optical Emission ◽  
Atomic Emission ◽  
The Body ◽  
Toxic Effects ◽  
Inductively Coupled

Packaging containing nanoparticles (NPs) can increase the shelf life of products, but the presence of NPs may hazards human life. In this regard, there are reports regarding the side effect and cytotoxicity of nanoparticles. The main aim of this research was to study the migration of silver and copper nanoparticles from the packaging to the food matrix as well as the assessment techniques. The diffusion and migration of nanoparticles can be analyzed by analytical techniques including atomic absorption, inductively coupled plasma mass spectrometry, inductively coupled plasma atomic emission, and inductively coupled plasma optical emission spectroscopy, as well as X-ray diffraction, spectroscopy, migration, and titration. Inductively coupled plasma-based techniques demonstrated the best results. Reports indicated that studies on the migration of Ag/Cu nanoparticles do not agree with each other, but almost all studies agree that the migration of these nanoparticles is higher in acidic environments. There are widespread ambiguities about the mechanism of nanoparticle toxicity, so understanding these nanoparticles and their toxic effects are essential. Nanomaterials that enter the body in a variety of ways can be distributed throughout the body and damage human cells by altering mitochondrial function, producing reactive oxygen, and increasing membrane permeability, leading to toxic effects and chronic disease. Therefore, more research needs to be done on the development of food packaging coatings with consideration given to the main parameters affecting nanoparticles migration.

scholarly journals Epithelial Protein Lost in Neoplasm, EPLIN, the Cellular and Molecular Prospects in Cancers

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1038
Author(s):  
Jianyuan Zeng ◽  
Wen G. Jiang ◽  
Andrew J. Sanders
Keyword(s):  
The Body ◽  
Early Years ◽  
Actin Binding ◽  
Cell Cycle Gene ◽  
Lim Domain ◽  
The Past ◽  
Concise Review ◽  
Cancerous Cell ◽  
Cytoskeletal Dynamics ◽  
In Cells

Epithelial Protein Lost In Neoplasm (EPLIN), also known as LIMA1 (LIM Domain And Actin Binding 1), was first discovered as a protein differentially expressed in normal and cancerous cell lines. It is now known to be key to the progression and metastasis of certain solid tumours. Despite a slow pace in understanding the biological role in cells and body systems, as well as its clinical implications in the early years since its discovery, recent years have witnessed a rapid progress in understanding the mechanisms of this protein in cells, diseases and indeed the body. EPLIN has drawn more attention over the past few years with its roles expanding from cell migration and cytoskeletal dynamics, to cell cycle, gene regulation, angiogenesis/lymphangiogenesis and lipid metabolism. This concise review summarises and discusses the recent progress in understanding EPLIN in biological processes and its implications in cancer.

Chronic hypoxia induces LLC-PK1 cell proliferation and dedifferentiation by the activation of protein kinase C

1997 ◽  
Vol 272 (6) ◽  
pp. F809-F815 ◽  
Author(s):  
A. Sahai ◽  
C. Mei ◽  
A. Zavosh ◽  
R. L. Tannen
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Chronic Hypoxia ◽  
Thymidine Incorporation ◽  
Cell Number ◽  
Significant Inhibition ◽  
Hypoxic Conditions ◽  
Kinase C ◽  
Atp Levels ◽  
Sustained Activation

The effect of chronic hypoxia on the proliferation and dedifferentiation of LLC-PK1 cells was examined. Cultures were exposed either to hypoxia (3% O2) or normoxia (18% O2), and [3H]thymidine incorporation, cell number, and sodium-dependent glucose (Na/Glc) uptakes were assessed. Cultures exposed to hypoxia for 16 h significantly increased [3H]thymidine incorporation followed by a significant increase in cell number both at 24 and 48 h in comparison with respective normoxic controls. Cultures exposed to 24 and 72 h of hypoxia exhibited significant inhibition of Na/Glc uptake when compared with their respective normoxic counterparts. Significant inhibition of cell ATP levels were observed under hypoxic conditions. Acute reoxygenation of hypoxic cells normalized cell ATP levels without any effect on the Na/Glc uptake. Hypoxia also activated protein kinase C (PKC) at 1 and 4 h followed by a subsequent return to baseline with reactivation at 24 h, which remained sustained up to 72 h, suggesting both acute and sustained activation of PKC. Furthermore, the hypoxia-induced alterations in [3H]thymidine incorporation as well as Na/Glc uptake were mitigated by inhibitors of PKC. These results indicate that chronic hypoxia induces both proliferation and dedifferentiation of LLC-PK1 cells mediated, in part, by the activation of PKC.

scholarly journals Melatonin Effect on Cryopreserved Sperm Cells of Crioulo Stallions

2020 ◽  
Vol 5 (2) ◽  
pp. 1-8
Author(s):  
Eraldo L Zanella
Keyword(s):  
Plasma Membrane ◽  
Sperm Motility ◽  
Membrane Integrity ◽  
Male Gamete ◽  
The Body ◽  
Cellular Damage ◽  
Ros Generation ◽  
Sperm Cells ◽  
Beneficial Effects ◽  
Endogenous Antioxidant

The freezing/thawing process of spermatozoa can cause cellular damage to the male gamete, decreasing the fertilization potential due to the increase in the production of reactive oxygen species (ROS). Melatonin is a potent endogenous antioxidant that protects the body against the damage caused by ROS. This study has evaluated different melatonin concentrations on the sperm viability of cryopreserved semen of Crioulo stallions. For that, three ejaculates were collected from five stallions diluted in a commercial extender followed by centrifugation and resuspension in a commercial freezing extender supplemented with 0; 1.25; 2.5. 5mM of Melatonin before the cryopreservation process. After thawing, the evaluation was performed assessing motility and flow cytometry evaluations: the plasma membrane integrity (PI), the integrity of the acrosomal membrane (FITC-PNA), mitochondrial membrane potential (JC1), and ROS generation (DCF-DA). Our results showed that sperm motility in the group without Melatonin and the 1.25mM group did not show the difference; however, the groups 2.5mM and 5mM presented a reduction in sperm motility. The 1.25 mM concentration was able to protect the plasma membrane during the cryopreservation process, in addition to showing a significant reduction in the production of ROS and increasing the percentage of sperm with integral acrosome. It can also be seen that high concentrations of Melatonin did not show beneficial effects. In conclusion, the addition of 1.25 mM of the Melatonin in Crioulo sperm cells showed to have a protective effect on the sperm cell during cryopreservation.

scholarly journals Yogic Discipline in an individual human life

2021 ◽  
Vol 3 (4) ◽  
pp. 197-205
Author(s):  
Dharmalingam T.S ◽  
Balachandran P
Keyword(s):  
Human Life ◽  
Circulatory System ◽  
Vital Role ◽  
The Body ◽  
Self Control ◽  
Modern World ◽  
Breathing Exercise ◽  
Peace Of Mind ◽  
Self Confidence ◽  
Five Elements

In the modern world, the yoga plays a vital role in human life. To realise the truth and meaning of life, one has to practice yogic discipline in everyday living. The human body is made up of five elements such as akash, air, fire, water and earth. An air plays a very important role to survive by providing life energy. Everyday practice of pranayama would help in regulating respiratory system (Breathing exercise) as well as circulatory system. The physical exercises regulate the circulation of blood, heat, air in the body. The practice of asana would help in bringing flexibility in our muscular system so as to enhance the meditation process. The practice of meditation gives peace of mind and improves integirity. The practice of yoga will improve self-confidence, self-control, speaking truth, tolerance and social virtues. Each and every individual should practice yoga, asanas, meditation and do self-analysis exercises such as analysis of thoughts, moralisation of desires, nutralisation of anger and eradication of worries. This would help to bring hormoney between body and mind, habit and wisdom, self and society. Purpose and method and will and nature.

scholarly journals Comparison of Serum HIF-1α Levels in Swimming Athletes Before and After Hypoxic Non-Hypoxic Exercise

2020 ◽  
Vol 21 (1) ◽  
pp. 36-39
Author(s):  
Syahrastani Syahrastani ◽  
Argantos Argantos ◽  
Siska Alicia Farma
Keyword(s):  
Aerobic Exercise ◽  
The Body ◽  
Anaerobic Exercise ◽  
Adaptation To Hypoxia ◽  
Cross Sectional ◽  
Hypoxic Conditions ◽  
Before And After ◽  
Cross Sectional Design ◽  
Age Range ◽  
Hypoxic Exercise

The situation of lack of oxygen supply to cells and tissues is often not realized by many people (hypoxia). Hypoxia can occur in various situations in life. The main effect of hypoxia is the effect on the brain, so the body will do everything it can to restore the state of homeostasis. HIF-1α protein is a marker of hypoxic conditions. HIF-1α regulates the synthesis of many genes to maintain and restore body homeostasis from hypoxia to normoxia. This study was a descriptive study with cross-sectional design. The sample of this study were six swimming athletes with a 12-19 year age range who met the inclusion and exclusion criteria. The HIF-1α protein is measured by the ELISA method. Data were analyzed statistically. The results showed higher levels of HIF-1α after anaerobic exercise than the levels of HIF-1α before and after aerobic exercise. This is greatly influenced by the intensity of the exercise carried out. This proves that cellular adaptation to hypoxia is more stable in aerobic exercise, where the body's metabolism during aerobic exercise is more stable  

Sign in / Sign up

Export Citation Format

Share Document