scholarly journals ISSUE OF DETAILING THE CLASSIFICATIONS OF CONGENITAL CLEFT UPPER LIP AND PALATE

2020 ◽  
Vol 15 (4) ◽  
pp. 162-169 ◽  
Author(s):  
Yulia Rogozhina ◽  
Svetlana Blohina ◽  
Evgeniya Bimbas
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
International Standards ◽  
Individual Treatment ◽  
Upper Lip ◽  
Maxillofacial Region ◽  
Functional Changes ◽  
Anatomical Classification ◽  
Congenital Cleft

Subject. Congenital cleft of the upper lip and palate is one of the most common malformations of the maxillofacial region which percentage is 86-88 %. This defect causes a complex set of anatomical and functional changes in the structures of the face and palate, it negatively affects the development of the child's body, therefore, it requires competent definition and extensive professional knowledge on its systematization and early elimination. The purpose of research — study of the incidence of asymmetric cleft lip and palate on children and complement the clinical and anatomical classification of clefts options asymmetry of the affected tissues. Methodology. There was carried out a retrospective statistical analysis of case histories of 687 patients with congenital cleft of the upper lip and / or palate, who received treatment on the basis of State Autonomic Health Institution of the Sverdlovsk Region Multiprofile Clinical Medical Center «Bonum» for the period 2015—2019 with the determination of the variety of types of lesions. Results. Asymmetry of the affected tissues occurred in 8.59 % of cases of the total number of children (687 patients) who was born with maxillofacial pathology of the upper lip and palate which required clarification of the clinical anatomical classification and the choice of individual treatment tactics. A clinical and anatomical classification that takes into account asymmetric clefts of the upper lip and palate was proposed. Conclusions. The allocation of asymmetric clefts of the upper lip and palate into certain groups of lesions and an assessment of their frequency made it possible to present a classification of this type of defect, which expanded the idea of the variety of anomalies of the maxillofacial region. The classification we proposed takes into account in more detail the clinical features of the congenital cleft of the upper lip and palate and, thus, more fully meets the clinical requirements and international standards, which allowed us to develop new methods of surgical treatment of congenital cleft of the upper lip and palate, as well as to build management tactics for such patients together with other specialists.

scholarly journals THE MAIN DIRECTIONS IN THE COMPLEX REHABILITATION OF CHILDREN WITH CLEFT LIP AND PALATE

2013 ◽  
Vol 1 (1) ◽  
pp. 36-43 ◽  
Author(s):  
Yulia Vladimirovna Stepanova ◽  
Margarita Sergeevna Tsyplakova
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Social Adaptation ◽  
Psychological Help ◽  
Complex Treatment ◽  
Upper Lip ◽  
Orthopedic Treatment ◽  
Professional Psychological Help ◽  
Specialized Center ◽  
Congenital Cleft

Complex treatment of children with cleft lip and palate is complicated and multi-step. Treatment is conducted by high-skilled specialists. The organization and execution of this complex are possible only at the large specialized center. Coordinator of this work is the maxillofacial surgeon. The performance of rehabilitation circuits includes preoperative orthodontic and orthopedic treatment, operative intervention (reconstructive and plastic surgery), orthodontic and orthopedic treatment after operation. Post-operative conservative treatment prevents the development of secondary deformities of the nose and upper lip. Professional psychological help and long supervision promote the achievement of good social adaptation of patients with congenital cleft lip and palate, improvement of their health.

scholarly journals COMPLEX TREATMENT EFFICIENCY, ANALYZED IN CHILDREN WITH CONGENITAL CLEFT LIP AND PALATE, USING INTERNATIONAL CLASSIFICATION OF FUNCTIONING

2018 ◽  
Vol 35 (3) ◽  
pp. 74-78
Author(s):  
L I Aleksandrova
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
International Classification ◽  
International Classification Of Functioning ◽  
Functional Disorders ◽  
Group I ◽  
Wide Range ◽  
Bilateral Cleft Lip ◽  
Congenital Cleft

Aim. To determine the structure of functional disorders and their dynamic changes in children with congenital cleft lip and palate from the position of International Classification of Functioning. Materials and methods. The indices, included into International Classification of Functioning, were assessed in 77 children (age range 1 to 6 years) with congenital cleft lip and palate, who received a complex five-stage therapy. Results. Direct correlation between the type of cleft and the value of disorders in classification constituents “function” and “structure” was revealed. Thus, in patients with bilateral cleft lip and palate, disorders of functions reached 82 %, in children with one-sided cleft lip and palate - 45 %. In children of group I, more marked structural disorders were observed, forming from 24 to 96 %, in children of groups 2 and 3 - from 5 to 49 %. In children with bilateral cleft lip and palate, there were observed more marked abnormalities in the category “activity and participation” (25-95 %) compared to children of groups 2 and 3 (0-24 %). Conclusions. Application of International Classification of Functioning for children with congenital cleft lip and palate shows a wide range of the assessed functional disorders and the possibility of using it for dynamic analysis of efficiency and treatment.

scholarly journals Congenital cleft of the lip and palate in children: pathogenetical significance of matrix metalloproteinases

2019 ◽  
Vol 19 (2) ◽  
pp. 106-113
Author(s):  
Ayaz E. Mardanov ◽  
I. E. Smirnov ◽  
A. A. Mamedov
Keyword(s):  
Matrix Metalloproteinases ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Chromosomal Abnormalities ◽  
Maxillofacial Region ◽  
Diagnostic Significance ◽  
Live Births ◽  
New Methods ◽  
Congenital Cleft ◽  
Tissue Matrix

There are presented data about the prevalence offormation of congenital cleft lip and palate (CCLP) - one of the most common birth defects of the maxillofacial region in children. According to WHO the occurrence of children born with CCLP in the world is 0,6-1,6 cases per 1,000 live births, and varies greatly from the region to region and ethnic group residing there. At the same time, in 63,1% of patients there were established chromosomal abnormalities, and in 36,9% - non-chromosomal syndromes. In Russia, every year there are occurred from 3,5 to 5 thousand children with such defects that requires the development of new methods ofprevention of these malformations. There are reported modern views on the pathogenetical and potent diagnostic significance of the evaluation of the content of tissue matrix metalloproteinases (MMPs) and their inhibitors in mechanisms of the formation of CCLP, shown the probable associations of changes in the expression or activity of MMP and TIMP with various forms of malformations of the palate and upper jaw.

scholarly journals Median facial cleft syndrome: A case report

2021 ◽  
Vol 7 (2) ◽  
pp. 61-63
Author(s):  
Kaushik Bhattacharya ◽  
Aditya Shikar Bhattacharya ◽  
Neela Bhattacharya
Keyword(s):  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Upper Lip ◽  
Live Births ◽  
Facial Cleft ◽  
The Face ◽  
Median Cleft ◽  
Median Facial Cleft Syndrome ◽  
Congenital Cleft ◽  
Type 3

Congenital Cleft Lip and Palate is a common birth defect with an incidence of 1 in 600 to 800 live births. This defect usually affects either the left, right or in some cases both sides of the lip and is called a Tessier Type 3 cleft. Clefting of the face in the midline is exceedingly rare and such a case of a Median Facial Cleft Syndrome is being reported which occurs in nearly 1 in 1,000,000 live births. This was first described by Bechard in 1823 and can be sporadic or part of an inherited syndrome. The child had a median cleft of the upper lip, nose, and palate of a severe, complete variety, with absent philtrum of the upper lip, premaxilla, columella, nasal septum and vomer.

Aspects of orthodontic protocol in cleft lip and palate patients

2020 ◽  
Vol 20 (2) ◽  
pp. 137-142
Author(s):  
O. V. Dudnik ◽  
Ad. A. Mamedov ◽  
O. I. Admakin ◽  
A. A. Skakodub ◽  
Y. O. Volkov ◽  
...  
Keyword(s):  
Oral Hygiene ◽  
Orthodontic Treatment ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Comprehensive Approach ◽  
Maxillofacial Region ◽  
Indirect Methods ◽  
Indirect Bonding ◽  
The Face ◽  
Direct And Indirect Methods

Relevance. Cleft lip and palate is one of the severe malformations of the face and jaw, requiring a comprehensive approach to the rehabilitation of the patients, including doctors of various specialties, one of which is orthodontists. A feature of orthodontic treatment is difficulty of fixing bracket systems, as well as lowering the level of oral hygiene, caused by deformation and displacement of fragments of the maxillofacial region.Purpose. Improving the effectiveness of orthodontic treatment and hygiene of the oral caviti in patients with cleft lip and palate in permanent bite period.Materials and methods. A comparison was made of the effetctiveness of fixing brackets systmes with direct and indirect bonding techniques and the effectiveness of oral hygiene during orthodontic treatment using irrigators.Results. The results of the study showed a difference in the effectiveness of using direct and indirect methods of fixing bracket systems in patients with cleft and palate. The use of irrigators as additional means of oral hygiene has demonstrated a positive dynamic of hygiene indices.Conclusions. Results of the study demonstrate the advantages of fixation the brackets by indirect bonding and use additional hygiene products irrigator for improving of oral hygiene.

Impact of cleft palate repair on speech and development of dentoalveolar deformities

2021 ◽  
Vol 16 (3) ◽  
pp. 47-53
Author(s):  
Yu.V. Stebeleva ◽  
◽  
Ad.A. Mamedov ◽  
Yu.O. Volkov ◽  
A.B. McLennan ◽  
...  
Keyword(s):  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Surgical Techniques ◽  
Normal Functioning ◽  
Primary Surgery ◽  
Cleft Palate Repair ◽  
Congenital Cleft ◽  
Palate Repair ◽  
Late Postoperative Period

Surgical repair of cleft palate is quite difficult because it aims not only to eliminate the anatomical defect of the palate, but also to ensure normal functioning, including speech. Moreover, successful surgery implies no or minimal deformation of the middle face that can be corrected in the late postoperative period. No doubt that primary surgery (both in terms of technique and time) is crucial for further growth and development of the maxilla. However, surgical techniques and the age of primary cleft palate repair vary between different clinics, which makes this literature review highly relevant. Key words: cleft palate repair, cleft palate, congenital cleft lip and palate

scholarly journals MOLECULAR GENETIC STUDY OF THE IMPACT OF SNP C677T OF THE GENE MTHFR IN THE DEVELOPMENT OF CONGENITAL ISOLATED CLEFT LIP AND PALATE

2018 ◽  
Vol 25 (5) ◽  
pp. 104-110
Author(s):  
V. S. Uchaeva ◽  
Yu. A. Vasiliev ◽  
A. S. Gracheva ◽  
O. V. Gulenko ◽  
I. G. Udina
Keyword(s):  
Genetic Study ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Control Group ◽  
Population Genetic Study ◽  
Molecular Genetic Study ◽  
Increased Risk ◽  
Significant Difference ◽  
Congenital Cleft ◽  
The Impact

Aim. This research was designed to conduct an associative population genetic study for the consideration of the impact of SNP C677T of the gene MTHFR in the congenital maxillofacial developmental anomalies (CMDA): congenital cleft lip (CCL), congenital cleft palate (CCP), congenital cleft lip and palate (CCLP) in the Krasnodar territory. The aim of the study is to establish the associations between SNP C677T of the gene MTHFR and the development of congenital cleft lip and/ or palate.Materials and methods. In this research, the peculiarities of distribution of SNP C667T of the gene MTHFR in children with congenital cleft lip and/or palate (n=223) and their mothers (n=78) in comparison with the control group (n=124) were studied in the Krasnodar territory. The genetic demographic questionnaires were gathered for children with CMDA, the information about diagnosis was obtained from the medical records. The biological samples, including blood or scrapings of oral mucosa, were collected from children with the pathology and their mothers. The DNA was extracted from the samples by the standard method. The study of the peculiarities of distribution of alleles of SNP C677T of the gene MTHFR was performed by PCR-PFLP with endonuclease Hinf I or by tetra-primer ARMS-PCR method in children with CCL, CCP, CCLP, their mothers and the control group. Statistical processing of the obtained data was performed by the algorithms of the “Statistica” program.Results. While comparing the profiles of frequencies of SNP C677T in children with CCL, CCP and CCLP with the control group, there were identified no significant differences in the frequency of this SNP and no peculiarities of genotypes distribution. There was identified a significant difference in the peculiarities of genotypes distribution with the control group (G=19,5232, d.f.=1, p<0,001) as well as united genotypes (С/C и С/T) in accordance to T/T (G=10,4657, d.f.=1; p<0,001) and united genotypes (C/T и T/T) in accordance to C/C (G=15,1896, d.f.=1, p<0,001) for the mothers of children with CCL, CCP and CCLP.Conclusion. As a result of the study, we established the association of SNP C677T of the MTHFR gene with the development of congenital cleft lip and/or palate: mothers’ T/T genotype is associated with the increased risk of giving birth to a child with CCL, CCP and CCLP (in comparison with mothers with C/C+C/T genotype): odds ratio [OR]=16,63, 95% CI: 3,86-71,71; p=0,0003 and also for mothers with genotypes (C/T+T/T) in comparison with mothers with genotypes C/C: OR=3,22, CI:1,71-6,08; p=0,0002. The amount of risk is not significant in children with CMDA for T/T genotype. So it is possible to make a conclusion about the impact of C677T of the gene MTHFR in the development of CCL, CCP and CCLP only in mother’s genotype. 

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