scholarly journals Restrain of beta-cell destruction and stimulation of beta-cell regeneration in type 1 diabetes

2015 ◽  
Vol 14 (3) ◽  
pp. 35-40
Author(s):  
Leszek Szewczyk ◽  
◽  
Anna Bury ◽  
Robert Piekarski ◽  
◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Stimulation Of

scholarly journals Beta-cell destruction and preservation in childhood and adult onset type 1 diabetes

Endocrine ◽  
2015 ◽  
Vol 49 (3) ◽  
pp. 693-702 ◽  
Author(s):  
Ananta Poudel ◽  
Omid Savari ◽  
Deborah A. Striegel ◽  
Vipul Periwal ◽  
Jerome Taxy ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Adult Onset ◽  
Onset Type ◽  
Beta Cell Destruction ◽  
Cell Destruction

scholarly journals Islet–immune interactions in type 1 diabetes: the nexus of beta cell destruction

2019 ◽  
Vol 198 (3) ◽  
pp. 326-340 ◽  
Author(s):  
L. Peters ◽  
A. Posgai ◽  
T. M. Brusko
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Beta Cell Destruction ◽  
Cell Destruction

Autoimmunity and beta Cell Regeneration in Mouse and Human Type 1 Diabetes: The Peace Is Not Enough

2007 ◽  
Vol 1103 (1) ◽  
pp. 19-32 ◽  
Author(s):  
V. ABLAMUNITS ◽  
N. A. SHERRY ◽  
J. A. KUSHNER ◽  
K. C. HEROLD
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Human Type ◽  
Human Type 1 Diabetes

scholarly journals Islet-Specific CTL Cloned from a Type 1 Diabetes Patient Cause Beta-Cell Destruction after Engraftment into HLA-A2 Transgenic NOD/SCID/IL2RG Null Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e49213 ◽  
Author(s):  
Wendy W. J. Unger ◽  
Todd Pearson ◽  
Joana R. F. Abreu ◽  
Sandra Laban ◽  
Arno R. van der Slik ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Diabetes Patient ◽  
Beta Cell Destruction ◽  
Cell Destruction

scholarly journals Reappearance of C-Peptide During the Third Trimester of Pregnancy in Type 1 Diabetes: Pancreatic Regeneration or Fetal Hyperinsulinism?

2021 ◽  
Author(s):  
Claire L Meek ◽  
Richard A Oram ◽  
Timothy J McDonald ◽  
Denice S Feig ◽  
Andrew T Hattersley ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cord Blood ◽  
Geometric Mean ◽  
Maternal Serum ◽  
Cell Regeneration ◽  
Third Trimester ◽  
C Peptide ◽  
Beta Cell Regeneration

Objective: We assessed longitudinal patterns of maternal C-peptide concentration to examine the hypothesis of beta-cell regeneration in type 1 diabetes pregnancy. <p>Research Design & Methods: C-peptide was measured on maternal serum samples from 127 participants (12, 24, 34 weeks) and cord blood during the continuous glucose monitoring in type 1 diabetes pregnancy trial (CONCEPTT). C-peptide was measured using a highly sensitive direct and solid-phase competitive electrochemiluminescent immunoassay. </p> <p>Results: Three discrete patterns of maternal C-peptide trajectory were identified: Pattern 1 undetectable throughout pregnancy, n=74 (58%, maternal C-peptide <3 pmol/l); Pattern 2 detectable at baseline, n=22 (17%, maternal C-peptide 7-272 pmol/l at baseline); Pattern 3 undetectable maternal C-peptide at 12 and 24 weeks which first became detectable at 34 weeks, n=31 (24%; maternal C-peptide 4-26 pmol/l at 34 weeks). Baseline characteristics and third trimester glucose profiles of women with pattern 1 and pattern 3 C-peptide trajectories were similar but women in pattern 3 had suboptimal glycemia (50% time above range) at 24 weeks gestation. Offspring of women with pattern 3 C-peptide trajectories had elevated cord blood C-peptide (geometric mean 1319 vs 718 pmol/l; p=0.007), increased rates of large-for-gestational-age (90% vs 60%; p=0.002) neonatal hypoglycemia (42% vs 14%; p=0.001), and neonatal intensive care admission (45% vs 23%; p=0.023) compared to pattern 1 offspring. </p> <p>Conclusion: First maternal C-peptide appearance at 34 weeks was associated with mid-trimester hyperglycemia, elevated cord blood C-peptide and high rates of neonatal complications. This suggests transfer of C-peptide from fetal to maternal serum and is inconsistent with pregnancy-related beta-cell regeneration.</p>

scholarly journals Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes

Diabetologia ◽  
2006 ◽  
Vol 49 (8) ◽  
pp. 1838-1844 ◽  
Author(s):  
J. J. Meier ◽  
J. C. Lin ◽  
A. E. Butler ◽  
R. Galasso ◽  
D. S. Martinez ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Direct Evidence ◽  
Cell Regeneration ◽  
Beta Cell Regeneration ◽  
Recent Onset ◽  
Onset Type
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