Estrogen-like and antioxidant properties of resveratrol in clinical pharmacology and therapeutic use

2021 ◽  
Vol 12_2021 ◽  
pp. 37-48
Author(s):  
Kareva E.N. Kareva ◽  
Smetnik A.A. Smetnik ◽  
◽  
Keyword(s):  
Clinical Pharmacology ◽  
Antioxidant Properties ◽  
Therapeutic Use

Clinical Pharmacology and Therapeutic Use of Digitalis Glycosides1

Drugs ◽  
1973 ◽  
Vol 6 (3???4) ◽  
pp. 182-221 ◽  
Author(s):  
J. E. Doherty ◽  
J. J. Kane
Keyword(s):  
Clinical Pharmacology ◽  
Therapeutic Use

scholarly journals Therapeutic use of the rebound effect of modern drugs: "New homeopathic medicines"

2017 ◽  
Vol 63 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Marcus Zulian Teixeira
Keyword(s):  
Clinical Pharmacology ◽  
Adverse Events ◽  
Rebound Effect ◽  
Clinical Manifestations ◽  
Therapeutic Use ◽  
Secondary Reaction ◽  
Specific Method ◽  
Paradoxical Effect ◽  
Homeopathic Treatment ◽  
Primary Action

Summary The homeopathic treatment is based on the principle of therapeutic similitude, employing medicines that cause certain disorders to treat similar manifestations, stimulating a reaction of the organism against its own ailments. The occurrence of this secondary reaction of the organism, opposite in nature to the primary action of the medicines, is evidenced in the study of the rebound (paradoxical) effect of several classes of modern drugs. In this work, in addition to substantiate the principle of similitude before the experimental and clinical pharmacology, we suggest a proposal to employ hundreds of conventional drugs according to homeopathic method, applying the therapeutic similitude between the adverse events of medicines and the clinical manifestations of patients. Describing existing lines of research and a specific method for the therapeutic use of the rebound effect of modern drugs (http://www.newhomeopathicmedicines.com), we hope to minimize prejudices related to the homeopathy and contribute to a broadening of the healing art.

scholarly journals Synthesis and Evaluation of Biological Activities of Bis(spiropyrazolone)cyclopropanes: A Potential Application against Leishmaniasis

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4960
Author(s):  
Olalla Barreiro-Costa ◽  
Gabriela Morales-Noboa ◽  
Patricio Rojas-Silva ◽  
Eliana Lara-Barba ◽  
Javier Santamaría-Aguirre ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
In Silico ◽  
Potential Application ◽  
Mammalian Cells ◽  
Biological Activities ◽  
Antioxidant Properties ◽  
Therapeutic Use ◽  
Derivatives Of

This work focuses on the search and development of drugs that may become new alternatives to the commercial drugs currently available for treatment of leishmaniasis. We have designed and synthesized 12 derivatives of bis(spiropyrazolone)cyclopropanes. We then characterized their potential application in therapeutic use. For this, the in vitro biological activities against three eukaryotic models—S. cerevisiae, five cancer cell lines, and the parasite L. mexicana—were evaluated. In addition, cytotoxicity against non-cancerous mammalian cells has been evaluated and other properties of interest have been characterized, such as genotoxicity, antioxidant properties and, in silico predictive adsorption, distribution, metabolism, and excretion (ADME). The results that we present here represent a first screening, indicating two derivatives of bis(spiropyrazolone)cyclopropanes as good candidates for the treatment of leishmaniasis. They have good specificity against parasites with respect to mammalian cells.

scholarly journals A thermodynamic and kinetic study of the antioxidant activity of natural hydroanthraquinones

RSC Advances ◽  
2020 ◽  
Vol 10 (34) ◽  
pp. 20089-20097 ◽  
Author(s):  
Quan V. Vo ◽  
Nguyen Minh Thong ◽  
Trinh Le Huyen ◽  
Pham Cam Nam ◽  
Nguyen Minh Tam ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Kinetic Study ◽  
Antioxidant Properties ◽  
Therapeutic Use

Novel hydroanthraquinones isolated from Talaromyces islandicus EN-501 exhibited promising antioxidant properties in preliminary studies, raising the prospect of adapting these compounds for therapeutic use in diseases caused by oxidative stress.

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