Autologous platelet rich plasma in complex therapy of women with refractory ‘‘thin’’ endometrium

2021 ◽  
Vol 4_2021 ◽  
pp. 112-119
Author(s):  
Apolikhina I.A. Apolikhina ◽  
Efendieva Z.N. Efendieva ◽  
Fedorova T.A. Fedorova ◽  
Belousov D.M. Belousov ◽  
Vishnyakova P.A. Vishnyakova ◽  
...  
Keyword(s):  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Complex Therapy ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

Effectiveness of intrauterine administration of autologous platelet-rich plasma for the preparation of the "thin" endometrium for the program of defrosted embryo transfer

2021 ◽  
Vol 2_2021 ◽  
pp. 90-95
Author(s):  
Dzhincharadze L.G. Dzhincharadze ◽  
Abubakirov A.N. Abubakirov ◽  
Mishieva N.G. Mishieva ◽  
Bakuridze E.M. Bakuridze ◽  
Bystrykh O.A. Bystrykh ◽  
...  
Keyword(s):  
Embryo Transfer ◽  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Treatment of unexplained thin endometrium with autologous platelet-rich plasma in a frozen embryo transfer cycle

2019 ◽  
Vol 2 (2) ◽  
pp. 80-82
Author(s):  
Sara Mahmood ◽  
Salma Kafeel ◽  
Riffat Bibi ◽  
Naveed Iqbal
Keyword(s):  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Uterine Cavity ◽  
Blastocyst Stage ◽  
Frozen Embryo Transfer ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet ◽  
Endometrial Proliferation

Inadequate endometrial proliferation is a known cause of implantation failure in assisted reproductive technology cycles. It is generally agreed that >9 mm endometrial thickness is associated with higher implantation. Several strategies have been explored to enhance endometrial proliferation. However, the results are either poor, inconsistent or subject to safety concerns. A 34-year old woman presented with unexplained thin endometrium in successive frozen embryo transfer (FET) cycles. Autologous platelet-rich plasma (PRP) was infused in the uterine cavity on day 10 of second FET cycle enhancing endometrial thickness, which post-PRP infusion measured 10.9 mm. Blastocyst-stage embryos were transferred resulting in a successful pregnancy. Autologous intrauterine infusion of PRP positively impacts endometrial proliferation and implantation which is safe, low resource and minimally invasive.

Comparative study of intrauterine infusion of autologous platelet rich plasma in unresponsive thin endometrium in frozen ET cycle

2019 ◽  
Vol 6 (2) ◽  
pp. 99
Author(s):  
Zeepee Godha ◽  
K.D. Nayar ◽  
Meenal Singh ◽  
Shweta Gupta ◽  
Monica Gupta ◽  
...  
Keyword(s):  
Comparative Study ◽  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

scholarly journals Effectiveness of Intrauterine Infusion of Autologous Platelet-Rich Plasma in the Treatment of Thin Endometrium of Infertile Women

2021 ◽  
pp. 521-526
Author(s):  
Namrata Choudhary ◽  
Akash More ◽  
Roshankumar Jha ◽  
Ashish P. Anjankar
Keyword(s):  
In Vitro Fertilization ◽  
Endometrial Thickness ◽  
Platelet Rich Plasma ◽  
Thin Endometrium ◽  
Vitro Fertilization ◽  
Infertile Women ◽  
Female Patients ◽  
Autologous Platelet Rich Plasma ◽  
Autologous Platelet

One of the key factors in implantation and pregnancy is endometrium. Sufficiently great percentage of in vitro fertilization failure is because of the endometrial receptivity therefore, high quality embryo and adequate receptive endometrial growth are important for successful implantation. Platelet rich plasma has beneficial effect in advancement of endometrial thickness for women with thin endometrial thickness. PRP can be used in various medical conditions including  patients with refractory endometrium as a complementary therapy to conventional  treatment. Aim: To determine the effectiveness of intrauterine infusion of autologous platelet-rich plasma in the treatment of thin endometrium of infertile women. Objectives: To identify infertile female patients with inadequate endometrial growth (less than 7 mm) in the past frozen embryo transfer (FET) cycles despite standard treatments. To observe intrauterine infusion of autologous platelet-rich plasma (PRP) in these infertile female patients with thin endometrium. To determine the effectiveness of intrauterine infusion of autologous PRP in the treatment of thin endometrium of infertile women during In vitro fertilization (IVF). Methods: It is a prospective observational study. Present study will be carried out with 30 patients. Women having inappropriate endometrial thickness of less than 7 mm, in past FET cycles will be included. Sonographic machine will be used; to measure endometrial thickness by  an expert Gynecologist, where thickest part of uterus will be measured in longitudinal  axis.  Expected Results: It is expected that intra uterine infusion of PRP will be effective in thickening of endometrial wall in patients with thin endometrium. Once the results are satisfactory it can be helpful for endometrial preparation in reproduction techniques. Conclusion: Present study is purposed to testify PRP as a novel method for advancement of reproductive medicine, it will be helpful to overcome with the issues such as inadequate thickness of endometrium, poor response to conventional therapy and increase clinical pregnancies and live births positively.

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