Analysis of Occupational Balance by Gender and Age of Healthy Adult Using Occupational Balance Assessment

Abstract Introduction SUVN-G3031 is a potent and selective histamine H3 receptor inverse agonist currently being developed for the treatment of narcolepsy. SUVN-G3031 produced robust wake promoting and anticataplectic effects in animal model relevant to the disease. This supports its therapeutic utility in the treatment of sleep related disorders like narcolepsy with and without cataplexy. Methods Two Phase 1 studies were conducted to assess safety, tolerability and pharmacokinetics (PK) of SUVN-G3031. In the first study, single ascending doses of 0.1 mg to 20 mg SUVN-G3031 were administered to healthy subjects. For multiple ascending dose cohorts, doses of 1 mg to 6 mg were administered for 14 days. In the second Phase 1 study, effects of food, gender and age on the PK of SUVN-G3031 were assessed. Results SUVN-G3031 absorbed rapidly following single oral administration and the exposures (Cmax and AUC) were dose proportional at the tested doses between 0.1 mg to 20 mg. SUVN-G3031 attained steady state on day six and achieved projected efficacy concentrations following repeated administrations. Food, gender and age had no effect on pharmacokinetics of SUVN-G3031. SUVN-G3031 was well tolerated up to 20 mg/ day single dose and 6 mg repeated dose in healthy adult subjects. There were no serious adverse events reported by any subject during Phase 1 studies. Conclusion SUVN-G3031 was well tolerated in humans with adequate plasma exposures for efficacy and has favorable pharmacokinetics suitable for once a day oral administration. SUVN-G3031 is currently being evaluated in a Phase 2 study as monotherapy for the treatment of narcolepsy with and without cataplexy (ClinicalTrials.gov Identifier: NCT04072380). Support None

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Effects of gender and age on thixotropic properties of whole blood from healthy adult subjects

Biorheology ◽

10.3233/bir-1991-283-409 ◽

1991 ◽

Vol 28 (3-4) ◽

pp. 177-183 ◽

Cited By ~ 4

Author(s):

Huai-Qing Chen ◽

Gui-Hui Zhong ◽

Liang Li ◽

Xiao-Ying Wang ◽

Tong Zhou ◽

...

Keyword(s):

Whole Blood ◽

Healthy Adult ◽

Gender And Age

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L-Carnitine Tartrate Supplementation for 5 Weeks Improves Exercise Recovery in Men and Women: A Randomized, Double-Blind, Placebo-Controlled Trial

Nutrients ◽

10.3390/nu13103432 ◽

2021 ◽

Vol 13 (10) ◽

pp. 3432

Author(s):

Matthew Stefan ◽

Matthew Sharp ◽

Raad Gheith ◽

Ryan Lowery ◽

Charlie Ottinger ◽

...

Keyword(s):

Healthy Adult ◽

Controlled Trial ◽

High Volume ◽

Short Term ◽

Lower Serum ◽

Double Blind ◽

Double Blind Placebo ◽

Exercise Challenge ◽

Exercise Training Program ◽

Gender And Age

L-carnitine tartrate has been shown to improve relatively short-term recovery among athletes. However, there is a lack of research on the longer-term effects in the general population. Objective: The primary objectives of this randomized double-blind, placebo-controlled trial were to evaluate the effects of daily L-carnitine tartrate supplementation for 5 weeks on recovery and fatigue. Method: In this study, eighty participants, 21- to 65-years-old, were recruited. Participants were split into two groups of forty participants each, a placebo, and a L-carnitine Tartrate group. Seventy-three participants completed a maintenance exercise training program that culminated in a high-volume exercise challenge. Results: Compared to placebo, L-carnitine tartrate supplementation was able to improve perceived recovery and soreness (p = 0.021), and lower serum creatine kinase (p = 0.016). In addition, L-carnitine tartrate supplementation was able to blunt declines in strength and power compared to placebo following an exercise challenge. Two sub-analyses indicated that these results were independent of gender and age. Interestingly, serum superoxide dismutase levels increased significantly among those supplementing with L-carnitine tartrate. Conclusions: These findings agree with previous observations among healthy adult subjects and demonstrate that L-carnitine tartrate supplementation beyond 35 days is beneficial for improving recovery and reducing fatigue following exercise across gender and age.

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The Normative Study of Acoustic and Aerodynamic Characteristics of Voice among Healthy Adult Turkish Speaker Population

BioMed Research International ◽

10.1155/2021/9217236 ◽

2021 ◽

Vol 2021 ◽

pp. 1-16

Author(s):

Ayşegül Zencir Şen ◽

Bülent Toğram

Keyword(s):

Normative Data ◽

Healthy Adult ◽

Voice Disorders ◽

Gender Effects ◽

Evaluation Instrument ◽

Age And Gender ◽

Gender Interaction ◽

Gender And Age ◽

Interaction Variables ◽

And Gender

Phonatory Aerodynamic System (PAS Model 6600) is an evaluation instrument that assesses the effectiveness of surgical interventions, treatments, and therapy for voice disorders. It can be used for the assessment of voice disorders by supporting other perceptual and instrumental methods. It is important to establish normative data, because the use of appropriate norms is necessary for diagnostic and descriptive accuracy. Therefore, this study is aimed primarily at establishing adult normative databases for phonatory aerodynamic measures obtained with the KayPENTAX PAS Model 6600 among healthy adult Turkish speakers and then examining the effect of age, gender, and age-gender interaction variables on these measures. The contribution of the study is considered so important since it will generate normative data for all measurements—except the mean pitch—by the five protocols of PAS for the first time. Two hundred and six healthy Turkish speakers with normal voice (106 women and 100 men) were included in the study and stratified into three age groups. Forty-five phonatory aerodynamic measures across five PAS protocols (vital capacity, maximum sustained phonation, comfortable sustained phonation, variation in sound pressure level, and voicing efficiency) were collected. Age, gender, and age-gender interaction variables were analyzed for 45 PAS parameters. Significant gender and age effect was found for 30 and 19 variables, respectively. Gender-age interaction together was observed for only 6 parameters. Significant differences were not found for the remaining 10 parameters. Significant age and gender effects were observed for 35 phonatory and aerodynamic measures which are essential part of the objective clinical assessment of voice. Consequently, normative data used as reference in voice assessment should be generated according to age and gender differences.

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Repetitive subconcussive head impacts and changes in sensory processing for balance control

10.1101/648857 ◽

2019 ◽

Author(s):

Jaclyn B. Caccese ◽

Fernando V. Santos ◽

Eric Anson ◽

Thomas A. Buckley ◽

Felipe Yamaguchi ◽

...

Keyword(s):

Sensory Processing ◽

Repeated Measures ◽

Healthy Adult ◽

Balance Control ◽

Soccer Players ◽

Heel Strike ◽

Control Group ◽

Balance Assessment ◽

Head Impacts ◽

Repeated Measures Design

AbstractBackgroundRepetitive subconcussive head impacts (RHI) may be associated with current and future detrimental neurological effects. However, the effects of RHI on sensory processing for balance control is unknown and may have significant clinical implications if athletes are still participating in sport despite impairments.Research QuestionAre there changes in sensory processing for balance control during standing and walking following RHI?MethodsThirty healthy, adult, amateur soccer players (15 males, 15 females, 21.8±2.8 years, 69.9±11.5 kg, 171.4±8.2 cm) volunteered for the standing balance assessment (i.e., experiment 1). A distinct cohort of twenty healthy, adult, amateur soccer players (10 males, 10 females, 22.3±4.5 years, 70.0±10.5 kg, 170.5±9.8 cm) volunteered for the walking balance assessment (i.e., experiment 2). We used a repeated measures design across three time points (pre-heading, 0-hours post-heading, 24-hours post-heading). Participants were randomly assigned to an experimental (i.e., performed 10 soccer headers in 10 minutes) or a control group (i.e., did not perform any soccer heading between sessions). In experiment 1, participants stood in a virtual reality cave while experiencing simultaneous perturbations to their visual, vestibular, and proprioceptive systems. In experiment 2, participants walked blindfolded along a foam walkway and experienced a vestibular perturbation on the second heel strike of the right foot. Changes in sensory processing were assessed using repeated measures ANOVAs.ResultsThere were no changes in sensory reweighting during experiment 1 and no changes in balance responses to the vestibular stimulus in experiment 2.SignificanceAlthough the cumulative effects of RHI may result in later-life cognitive, behavioral, and mood impairments, a single episode of repeated soccer headers does not appear to be associated with acute impairments in sensory processing for balance control.

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Interplay among physical balance ability, physical activities realization, anthropometric parameters and psychosocial indices in relation to gender and age of seniors 65+

Physical Activity Review ◽

10.16926/par.2020.08.14 ◽

2020 ◽

Vol 8 (1) ◽

pp. 121-132

Author(s):

Milada Krejci ◽

Martin Hill ◽

Elena Bendikova ◽

Dobroslava Jandova ◽

Jiri Kajzar

Keyword(s):

Psychosocial Factors ◽

Assessment Tool ◽

Physical Activities ◽

Balance Assessment ◽

Anthropometric Parameters ◽

Balance Test ◽

Gender And Age ◽

Sf 36 ◽

Balance Ability

Introduction: The study is aimed to analyze the interplay among the physical balance level, physical activities realization, anthropometric determinants and psychosocial indices in relation to gender and age of seniors 65+. Methods: The participants comprised 500 seniors in age 65+ (234 males and 266 females) participated voluntarily in the research. For data collection we used methods of the “Medical anamnesis”, “Tinetti Balance Assessment Tool”, “Health Survey SF-36”. For statistics analyses the multivariate regression with reduction of dimensionality and orthogonal projection to latent structure was used. Results: Analyzed disabilities “Depression”, “Type 2 diabetes mellitus”, “Hypertension” and “Vertigo” significantly negatively interplay with the Tinneti summary balance score in both genders. Results of the anthropometric parameters of female seniors, in a contrast to the male seniors parameters, proved that body high and muscle mass correlate significantly positively with the performance of the Tinneti summary balance test (p<0.01) in female seniors. Conclusion: Performing of physical activities positively correlates with the performance in the Tinneti summary balance test in both genders of seniors. There are differences between male and female seniors according the psychosocial factors interplay with performance in the Tinneti summary balance test, when more interplaying psychosocial factors were analyzed in females.

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A racial difference in incidence of lactase deficiency. A survey of milk intolerance and lactase deficiency in healthy adult males

JAMA ◽

10.1001/jama.197.12.968 ◽

1966 ◽

Vol 197 (12) ◽

pp. 968-972 ◽

Cited By ~ 31

Author(s):

T. M. Bayless

Keyword(s):

Racial Difference ◽

Healthy Adult ◽

Adult Males ◽

Lactase Deficiency ◽

Milk Intolerance

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Letter to the Editor Concerning Skuk et al., “Parameter-Specific Morphing Reveals Contributions of Timbre and Fundamental Frequency Cues to the Perception of Voice Gender and Age in Cochlear Implant Users”

Journal of Speech Language and Hearing Research ◽

10.1044/2020_jslhr-20-00563 ◽

2020 ◽

Vol 63 (12) ◽

pp. 4325-4326 ◽

Cited By ~ 1

Author(s):

Hartmut Meister ◽

Katrin Fuersen ◽

Barbara Streicher ◽

Ruth Lang-Roth ◽

Martin Walger

Keyword(s):

Cochlear Implant ◽

Fundamental Frequency ◽

Stimulus Type ◽

Voice Perception ◽

Letter To The Editor ◽

Gender And Age ◽

General Influence

Purpose The purpose of this letter is to compare results by Skuk et al. (2020) with Meister et al. (2016) and to point to a potential general influence of stimulus type. Conclusion Our conclusion is that presenting sentences may give cochlear implant recipients the opportunity to use timbre cues for voice perception. This might not be the case when presenting brief and sparse stimuli such as consonant–vowel–consonant or single words, which were applied in the majority of studies.

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